hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01031.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CEP43 | Centrosomal protein 43 (FGFR1 oncogene partner) | 5 | UniProt NCBI |
| CEP78 | Centrosomal protein of 78 kDa (Cep78) | 5 | UniProt NCBI |
| CEP350 | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | 5 | UniProt NCBI |
| WRAP73 | WD repeat-containing protein WRAP73 (WD repeat-containing protein 8) (WD repeat-containing protein antisense to TP73 gene) | 5 | UniProt NCBI |
| CCDC18 | Coiled-coil domain-containing protein 18 (Sarcoma antigen NY-SAR-24) | 3 | UniProt NCBI |
| C2CD3 | C2 domain-containing protein 3 | 5 | UniProt NCBI |
| CEP72 | Centrosomal protein of 72 kDa (Cep72) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005813 | 4.64625258519e-06 | 1.0 | CEP72 CEP78 CCDC18 CEP43 C2CD3 CEP350 WRAP73 | centrosome |
| REAC:R-HSA-5620912 | 1.02705207546e-05 | 0.571428571429 | CEP72 C2CD3 CEP43 CEP78 | Anchoring of the basal body to the plasma membrane |
| GO:0005815 | 1.52930287321e-05 | 1.0 | CEP72 CEP78 CCDC18 CEP43 C2CD3 CEP350 WRAP73 | microtubule organizing center |
| REAC:R-HSA-5617833 | 0.000178285426161 | 0.571428571429 | CEP72 C2CD3 CEP43 CEP78 | Cilium Assembly |
| GO:0015630 | 0.000379537356703 | 1.0 | CEP72 CEP78 CCDC18 CEP43 C2CD3 CEP350 WRAP73 | microtubule cytoskeleton |
| REAC:R-HSA-380259 | 0.000589010657253 | 0.428571428571 | CEP72 CEP43 CEP78 | Loss of Nlp from mitotic centrosomes |
| REAC:R-HSA-380284 | 0.000589010657253 | 0.428571428571 | CEP72 CEP43 CEP78 | Loss of proteins required for interphase microtubule organization from the centrosome |
| REAC:R-HSA-8854518 | 0.000673985363387 | 0.428571428571 | CEP72 CEP43 CEP78 | AURKA Activation by TPX2 |
| REAC:R-HSA-1852241 | 0.000795701487611 | 0.571428571429 | CEP72 C2CD3 CEP43 CEP78 | Organelle biogenesis and maintenance |
| REAC:R-HSA-380287 | 0.000976813602208 | 0.428571428571 | CEP72 CEP43 CEP78 | Centrosome maturation |
| REAC:R-HSA-380270 | 0.000976813602208 | 0.428571428571 | CEP72 CEP43 CEP78 | Recruitment of mitotic centrosome proteins and complexes |
| REAC:R-HSA-2565942 | 0.0011785349263 | 0.428571428571 | CEP72 CEP43 CEP78 | Regulation of PLK1 Activity at G2/M Transition |
| REAC:R-HSA-380320 | 0.00150471527401 | 0.428571428571 | CEP72 CEP43 CEP78 | Recruitment of NuMA to mitotic centrosomes |
| GO:0005856 | 0.00665123557963 | 1.0 | CEP72 CEP78 CCDC18 CEP43 C2CD3 CEP350 WRAP73 | cytoskeleton |
| REAC:R-HSA-69275 | 0.01389705158 | 0.428571428571 | CEP72 CEP43 CEP78 | G2/M Transition |
| REAC:R-HSA-453274 | 0.0143393828868 | 0.428571428571 | CEP72 CEP43 CEP78 | Mitotic G2-G2/M phases |
| REAC:R-HSA-68877 | 0.015251615709 | 0.428571428571 | CEP72 CEP43 CEP78 | Mitotic Prometaphase |
| WP:WP4906 | 0.028073243565 | 0.285714285714 | CEP43 CEP350 | 3q29 copy number variation syndrome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CEP43 | CEP350 | 1.0 | 0.118 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM gupta () boldt_WMM |
| CCDC18 | CEP72 | 0.996 | 0.134528301887 | hein_WMM youn_WMM hein () gupta_WMM |
| CEP43 | CEP72 | 0.99 | 0.078 | hein_WMM youn_WMM hein () gupta_WMM |
| CEP43 | CCDC18 | 0.985 | 0.096 | hein_WMM youn_WMM hein () gupta_WMM |
| CEP350 | CCDC18 | 0.979 | 0.142 | hein_WMM youn_WMM gupta_WMM WMM_only |
| CCDC18 | C2CD3 | 0.976 | 0.15 | hein_WMM youn_WMM gupta_WMM WMM_only |
| CEP350 | C2CD3 | 0.975 | 0.164 | hein_WMM youn_WMM gupta_WMM WMM_only |
| CEP43 | C2CD3 | 0.973 | 0.082 | hein_WMM hein () gupta_WMM |
| WRAP73 | C2CD3 | 0.972 | 0.126 | hein_WMM youn_WMM gupta_WMM WMM_only |
| C2CD3 | CEP72 | 0.971 | 0.148 | hein_WMM youn_WMM gupta_WMM WMM_only |
| CEP43 | CEP78 | 0.967 | 0.044 | hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM |
| CEP43 | WRAP73 | 0.96 | 0.078 | hein_WMM youn_WMM gupta_WMM WMM_only |
| WRAP73 | CCDC18 | 0.956 | 0.086 | hein_WMM youn_WMM gupta_WMM WMM_only |
| CEP78 | CEP350 | 0.953 | 0.176 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| CEP350 | CEP72 | 0.948 | 0.206 | hein_WMM youn_WMM hein () gupta_WMM |
| CEP78 | CEP72 | 0.881 | 0.164 | hein_WMM youn_WMM hein () gupta_WMM |
| CEP350 | WRAP73 | 0.766 | 0.096 | hein_WMM youn_WMM gupta_WMM WMM_only |
| CEP78 | CCDC18 | 0.759 | 0.136 | hein_WMM youn_WMM gupta_WMM WMM_only |
| CEP78 | C2CD3 | 0.668 | 0.16 | hein_WMM youn_WMM gupta_WMM WMM_only |
| WRAP73 | CEP72 | 0.354 | 0.09 | hein_WMM youn_WMM gupta_WMM WMM_only |
| CEP78 | WRAP73 | 0.006 | 0.24 | bioplex3_WMM youn_WMM gupta_WMM WMM_only bioplex_WMM |
Related Complexes