hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_01056.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CENPC | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | 5 | UniProt NCBI |
| ZFX | Zinc finger X-chromosomal protein | 5 | UniProt NCBI |
| CENPN | Centromere protein N (CENP-N) (Interphase centromere complex protein 32) | 5 | UniProt NCBI |
| CENPU | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | 5 | UniProt NCBI |
| CENPL | Centromere protein L (CENP-L) (Interphase centromere complex protein 33) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1179 | 3.43312612619e-11 | 1.0 | CENPN CENPL CENPC CENPU | CENP-A NAC-CAD complex |
| CORUM:927 | 1.40299620761e-08 | 0.75 | CENPN CENPC CENPU | CENP-A NAC complex |
| GO:0000939 | 4.78889884367e-08 | 1.0 | CENPN CENPL CENPC CENPU | inner kinetochore |
| REAC:R-HSA-774815 | 5.01145184499e-08 | 1.0 | CENPN CENPL CENPC CENPU | Nucleosome assembly |
| REAC:R-HSA-606279 | 5.01145184499e-08 | 1.0 | CENPN CENPL CENPC CENPU | Deposition of new CENPA-containing nucleosomes at the centromere |
| CORUM:7394 | 1.15717477383e-07 | 0.75 | CENPN CENPL CENPU | CENP-H-I complex |
| CORUM:7388 | 1.54282047245e-07 | 0.75 | CENPN CENPC CENPL | CENP-A nucleosomal complex |
| REAC:R-HSA-141444 | 2.68326895976e-07 | 1.0 | CENPN CENPL CENPC CENPU | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 2.68326895976e-07 | 1.0 | CENPN CENPL CENPC CENPU | Amplification of signal from the kinetochores |
| REAC:R-HSA-69618 | 5.14641931672e-07 | 1.0 | CENPN CENPL CENPC CENPU | Mitotic Spindle Checkpoint |
| REAC:R-HSA-9648025 | 6.18321860525e-07 | 1.0 | CENPN CENPL CENPC CENPU | EML4 and NUDC in mitotic spindle formation |
| REAC:R-HSA-2500257 | 8.15826965699e-07 | 1.0 | CENPN CENPL CENPC CENPU | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-73886 | 9.92449541033e-07 | 1.0 | CENPN CENPL CENPC CENPU | Chromosome Maintenance |
| REAC:R-HSA-5663220 | 1.16032796813e-06 | 1.0 | CENPN CENPL CENPC CENPU | RHO GTPases Activate Formins |
| CORUM:929 | 4.19173080197e-06 | 0.75 | CENPU CENPC CENPL | CEN complex |
| REAC:R-HSA-2467813 | 4.43834795276e-06 | 1.0 | CENPN CENPL CENPC CENPU | Separation of Sister Chromatids |
| REAC:R-HSA-68877 | 5.60915382183e-06 | 1.0 | CENPN CENPL CENPC CENPU | Mitotic Prometaphase |
| REAC:R-HSA-68882 | 9.63108604686e-06 | 1.0 | CENPN CENPL CENPC CENPU | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 9.80619670226e-06 | 1.0 | CENPN CENPL CENPC CENPU | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-69620 | 2.37268629274e-05 | 1.0 | CENPN CENPL CENPC CENPU | Cell Cycle Checkpoints |
| REAC:R-HSA-195258 | 3.00975502897e-05 | 1.0 | CENPN CENPL CENPC CENPU | RHO GTPase Effectors |
| REAC:R-HSA-68886 | 8.8367525634e-05 | 1.0 | CENPN CENPL CENPC CENPU | M Phase |
| REAC:R-HSA-69278 | 0.000302817168596 | 1.0 | CENPN CENPL CENPC CENPU | Cell Cycle, Mitotic |
| GO:0000776 | 0.000369531169251 | 1.0 | CENPN CENPL CENPC CENPU | kinetochore |
| GO:0000779 | 0.000415139510394 | 1.0 | CENPN CENPL CENPC CENPU | condensed chromosome, centromeric region |
| REAC:R-HSA-194315 | 0.000624339554915 | 1.0 | CENPN CENPL CENPC CENPU | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 0.000681855532791 | 1.0 | CENPN CENPL CENPC CENPU | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| REAC:R-HSA-1640170 | 0.000694680089617 | 1.0 | CENPN CENPL CENPC CENPU | Cell Cycle |
| GO:0000775 | 0.00156892706691 | 1.0 | CENPN CENPL CENPC CENPU | chromosome, centromeric region |
| GO:0000793 | 0.00184343006403 | 1.0 | CENPN CENPL CENPC CENPU | condensed chromosome |
| GO:0098687 | 0.0111408206209 | 1.0 | CENPN CENPL CENPC CENPU | chromosomal region |
| GO:0007059 | 0.0117129540232 | 1.0 | CENPN CENPL CENPC CENPU | chromosome segregation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CENPN | CENPU | 0.996 | 0.322 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| CENPC | CENPN | 0.996 | 0.224 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| CENPC | CENPU | 0.996 | 0.21 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| ZFX | CENPU | 0.983 | 0.138 | hein_WMM bioplex3_WMM WMM_only |
| CENPC | CENPL | 0.964 | 0.242 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| CENPN | CENPL | 0.961 | 0.276 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| CENPU | CENPL | 0.956 | 0.216 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| CENPC | ZFX | 0.94 | 0.098 | hein_WMM bioplex3_WMM WMM_only |
| ZFX | CENPN | 0.898 | 0.1 | hein_WMM bioplex3_WMM WMM_only |
| ZFX | CENPL | 0.135 | 0.09 | bioplex3_WMM WMM_only |
Related Complexes