List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_01061.1

Confidence: Extremely High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
SDHAF2	Succinate dehydrogenase assembly factor 2, mitochondrial (SDH assembly factor 2) (SDHAF2)	5	UniProt   NCBI
MOCS1	Molybdenum cofactor biosynthesis protein 1 (Cell migration-inducing gene 11 protein) (Molybdenum cofactor synthesis-step 1 protein A-B) [Includes: GTP 3',8-cyclase (EC 4.1.99.22) (Molybdenum cofactor biosynthesis protein A); Cyclic pyranopterin monophosphate synthase (EC 4.6.1.17) (Molybdenum cofactor biosynthesis protein C)]	5	UniProt   NCBI
SDHAF4	Succinate dehydrogenase assembly factor 4, mitochondrial (SDH assembly factor 4) (SDHAF4)	4	UniProt   NCBI
SDHA	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II) (Fp)	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP4920	1.95685123169e-08	0.75	SDHAF2 SDHAF4 SDHA	Mitochondrial complex II assembly
HP:0001686	0.000501460556964	0.5	SDHAF2 SDHA	Loss of voice
HP:0012222	0.00350734148159	0.5	SDHAF2 SDHA	Arachnoid hemangiomatosis
HP:0011979	0.00350734148159	0.5	SDHAF2 SDHA	Elevated urinary dopamine level
HP:0009711	0.00350734148159	0.5	SDHAF2 SDHA	Retinal capillary hemangioma
HP:0000740	0.00350734148159	0.5	SDHAF2 SDHA	Episodic paroxysmal anxiety
HP:0008629	0.00350734148159	0.5	SDHAF2 SDHA	Pulsatile tinnitus
HP:0006737	0.00350734148159	0.5	SDHAF2 SDHA	Extraadrenal pheochromocytoma
HP:0003639	0.00350734148159	0.5	SDHAF2 SDHA	Elevated urinary epinephrine level
HP:0003574	0.00350734148159	0.5	SDHAF2 SDHA	Positive regitine blocking test
HP:0003345	0.00350734148159	0.5	SDHAF2 SDHA	Elevated urinary norepinephrine level
HP:0002864	0.00350734148159	0.5	SDHAF2 SDHA	Paraganglioma of head and neck
HP:0002640	0.00350734148159	0.5	SDHAF2 SDHA	Hypertension associated with pheochromocytoma
HP:0010532	0.00400802433742	0.5	SDHAF2 SDHA	Paroxysmal vertigo
HP:0100642	0.00400802433742	0.5	SDHAF2 SDHA	Neoplasm of the adrenal medulla
HP:0006748	0.00400802433742	0.5	SDHAF2 SDHA	Adrenal pheochromocytoma
HP:0001095	0.00454201288615	0.5	SDHAF2 SDHA	Hypertensive retinopathy
HP:0010797	0.00454201288615	0.5	SDHAF2 SDHA	Hemangioblastoma
HP:0002668	0.0051092979876	0.5	SDHAF2 SDHA	Paraganglioma
HP:0034902	0.00634372129255	0.5	SDHAF2 SDHA	Abnormal circulating calcitonin concentration
HP:0003528	0.00634372129255	0.5	SDHAF2 SDHA	Elevated circulating calcitonin concentration
HP:0011976	0.00634372129255	0.5	SDHAF2 SDHA	Elevated urinary catecholamine level
HP:0011281	0.00634372129255	0.5	SDHAF2 SDHA	Abnormality of urine catecholamine level
HP:0009594	0.00701084122037	0.5	SDHAF2 SDHA	Retinal hamartoma
HP:0002331	0.00844485194452	0.5	SDHAF2 SDHA	Recurrent paroxysmal headache
HP:0011703	0.0092117244708	0.5	SDHAF2 SDHA	Sinus tachycardia
HP:0030670	0.0100118295947	0.5	SDHAF2 SDHA	Hamartoma of the orbital region
HP:0010568	0.0100118295947	0.5	SDHAF2 SDHA	Hamartoma of the eye
HP:0001069	0.0100118295947	0.5	SDHAF2 SDHA	Episodic hyperhidrosis
HP:0002666	0.0108451581837	0.5	SDHAF2 SDHA	Pheochromocytoma
HP:0002574	0.0145105245688	0.5	SDHAF2 SDHA	Episodic abdominal pain
HP:0032148	0.0165423111708	0.5	SDHAF2 SDHA	Episodic pain
GO:0034553	0.0168521501606	0.5	SDHAF2 SDHAF4	mitochondrial respiratory chain complex II assembly
GO:0034552	0.0168521501606	0.5	SDHAF2 SDHAF4	respiratory chain complex II assembly
HP:0100530	0.0176079483787	0.5	SDHAF2 SDHA	Abnormal circulating calcium-phosphate regulating hormone concentration
HP:0100634	0.018706736024	0.5	SDHAF2 SDHA	Neuroendocrine neoplasm
HP:0000526	0.0246976114972	0.5	SDHAF2 SDHA	Aniridia
HP:0100631	0.0259951101914	0.5	SDHAF2 SDHA	Neoplasm of the adrenal gland
GO:0006121	0.0280843539964	0.5	SDHAF2 SDHA	mitochondrial electron transport, succinate to ubiquinone
HP:0031801	0.03008608933	0.5	SDHAF2 SDHA	Vocal cord dysfunction
HP:0001605	0.03008608933	0.5	SDHAF2 SDHA	Vocal cord paralysis
HP:0100012	0.03008608933	0.5	SDHAF2 SDHA	Neoplasm of the eye
HP:0001293	0.03008608933	0.5	SDHAF2 SDHA	Cranial nerve compression
HP:0000759	0.0302449882608	0.75	SDHAF2 MOCS1 SDHA	Abnormal peripheral nervous system morphology
HP:0031284	0.0315158796726	0.5	SDHAF2 SDHA	Flushing
HP:0025269	0.040788355352	0.5	SDHAF2 SDHA	Panic attack
HP:0000360	0.0476300363671	0.5	SDHAF2 SDHA	Tinnitus



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?	Evidence ?
SDHAF2	SDHA	0.999	0.088	hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     hein ()     bioplex3_HCT116
SDHAF4	SDHA	0.997	0.07	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116     fraction
MOCS1	SDHA	0.981	0.114	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
SDHAF2	SDHAF4	0.911	0.058	bioplex_WMM     bioplex3_WMM     WMM_only
SDHAF2	MOCS1	0.172	0.078	bioplex_WMM     bioplex3_WMM     WMM_only
MOCS1	SDHAF4	0.143	0.066	bioplex_WMM     bioplex3_WMM     WMM_only





Related Complexes

Genename	Complexes
SDHAF2	huMAP3_01061.1 huMAP3_04600.1 huMAP3_09045.1 huMAP3_12069.1 huMAP3_14997.1
MOCS1	huMAP3_01061.1 huMAP3_04600.1 huMAP3_05215.1 huMAP3_09045.1 huMAP3_10626.1 huMAP3_12311.1
SDHAF4	huMAP3_01061.1 huMAP3_09045.1 huMAP3_12069.1 huMAP3_14997.1
SDHA	huMAP3_01061.1 huMAP3_04600.1 huMAP3_09045.1 huMAP3_12069.1