hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01063.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RAB3GAP2 | Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) | 5 | UniProt NCBI |
| RAB3GAP1 | Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0100952 | 3.41752350426e-05 | 1.0 | RAB3GAP2 RAB3GAP1 | Enlarged sylvian cistern |
| HP:0000064 | 0.000943236487175 | 1.0 | RAB3GAP2 RAB3GAP1 | Hypoplastic labia minora |
| HP:0040255 | 0.00111069513888 | 1.0 | RAB3GAP2 RAB3GAP1 | Aplasia/Hypoplasia of the clitoris |
| HP:0000060 | 0.00111069513888 | 1.0 | RAB3GAP2 RAB3GAP1 | Clitoral hypoplasia |
| HP:0009465 | 0.00129182388461 | 1.0 | RAB3GAP2 RAB3GAP1 | Ulnar deviation of finger |
| HP:0012880 | 0.00138751454273 | 1.0 | RAB3GAP2 RAB3GAP1 | Abnormal labia minora morphology |
| GO:0097051 | 0.00140460216025 | 1.0 | RAB3GAP2 RAB3GAP1 | establishment of protein localization to endoplasmic reticulum membrane |
| REAC:R-HSA-6811436 | 0.00209323314636 | 1.0 | RAB3GAP2 RAB3GAP1 | COPI-independent Golgi-to-ER retrograde traffic |
| HP:0000480 | 0.00227607065384 | 1.0 | RAB3GAP2 RAB3GAP1 | Retinal coloboma |
| HP:0001264 | 0.00240251902349 | 1.0 | RAB3GAP2 RAB3GAP1 | Spastic diplegia |
| HP:0000221 | 0.00240251902349 | 1.0 | RAB3GAP2 RAB3GAP1 | Furrowed tongue |
| HP:0009738 | 0.00253238491666 | 1.0 | RAB3GAP2 RAB3GAP1 | Abnormal antihelix morphology |
| GO:1903061 | 0.0028092043205 | 1.0 | RAB3GAP2 RAB3GAP1 | positive regulation of protein lipidation |
| GO:1903373 | 0.0028092043205 | 1.0 | RAB3GAP2 RAB3GAP1 | positive regulation of endoplasmic reticulum tubular network organization |
| GO:0050747 | 0.0028092043205 | 1.0 | RAB3GAP2 RAB3GAP1 | positive regulation of lipoprotein metabolic process |
| HP:0000066 | 0.00435734246793 | 1.0 | RAB3GAP2 RAB3GAP1 | Labial hypoplasia |
| HP:0001193 | 0.00489047613459 | 1.0 | RAB3GAP2 RAB3GAP1 | Ulnar deviation of the hand or of fingers of the hand |
| HP:0012815 | 0.00507502240382 | 1.0 | RAB3GAP2 RAB3GAP1 | Hypoplastic female external genitalia |
| HP:0000649 | 0.00526298619656 | 1.0 | RAB3GAP2 RAB3GAP1 | Abnormality of visual evoked potentials |
| REAC:R-HSA-8876198 | 0.0055363880769 | 1.0 | RAB3GAP2 RAB3GAP1 | RAB GEFs exchange GTP for GDP on RABs |
| HP:0001845 | 0.00625406801279 | 1.0 | RAB3GAP2 RAB3GAP1 | Overlapping toe |
| HP:0000058 | 0.00688972738458 | 1.0 | RAB3GAP2 RAB3GAP1 | Abnormal labia morphology |
| GO:1903371 | 0.00702301080125 | 1.0 | RAB3GAP2 RAB3GAP1 | regulation of endoplasmic reticulum tubular network organization |
| REAC:R-HSA-9007101 | 0.0098732254038 | 1.0 | RAB3GAP2 RAB3GAP1 | Rab regulation of trafficking |
| HP:0000056 | 0.0105293899166 | 1.0 | RAB3GAP2 RAB3GAP1 | Abnormal clitoris morphology |
| HP:0002230 | 0.0124910484081 | 1.0 | RAB3GAP2 RAB3GAP1 | Generalized hirsutism |
| REAC:R-HSA-8856688 | 0.013456498798 | 1.0 | RAB3GAP2 RAB3GAP1 | Golgi-to-ER retrograde transport |
| HP:0030141 | 0.0172584936965 | 1.0 | RAB3GAP2 RAB3GAP1 | Abnormality of the posterior hairline |
| HP:0002162 | 0.0172584936965 | 1.0 | RAB3GAP2 RAB3GAP1 | Low posterior hairline |
| HP:0034398 | 0.0193807757926 | 1.0 | RAB3GAP2 RAB3GAP1 | Toe deformity |
| GO:1903059 | 0.0210690324038 | 1.0 | RAB3GAP2 RAB3GAP1 | regulation of protein lipidation |
| HP:0000482 | 0.0227948817734 | 1.0 | RAB3GAP2 RAB3GAP1 | Microcornea |
| HP:0000232 | 0.0260620342435 | 1.0 | RAB3GAP2 RAB3GAP1 | Everted lower lip vermilion |
| HP:0000601 | 0.026912997596 | 1.0 | RAB3GAP2 RAB3GAP1 | Hypotelorism |
| HP:0000055 | 0.0273436055576 | 1.0 | RAB3GAP2 RAB3GAP1 | Abnormal female external genitalia morphology |
| HP:0000519 | 0.0273436055576 | 1.0 | RAB3GAP2 RAB3GAP1 | Developmental cataract |
| REAC:R-HSA-6811442 | 0.0316599377434 | 1.0 | RAB3GAP2 RAB3GAP1 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| HP:0000044 | 0.0323058496858 | 1.0 | RAB3GAP2 RAB3GAP1 | Hypogonadotropic hypogonadism |
| HP:0000455 | 0.0323058496858 | 1.0 | RAB3GAP2 RAB3GAP1 | Broad nasal tip |
| HP:0008388 | 0.0327774679293 | 1.0 | RAB3GAP2 RAB3GAP1 | Abnormal toenail morphology |
| HP:0009832 | 0.0332525036964 | 1.0 | RAB3GAP2 RAB3GAP1 | Abnormal distal phalanx morphology of finger |
| HP:0100704 | 0.0346981161387 | 1.0 | RAB3GAP2 RAB3GAP1 | Cerebral visual impairment |
| GO:0050746 | 0.0365196561665 | 1.0 | RAB3GAP2 RAB3GAP1 | regulation of lipoprotein metabolic process |
| HP:0001302 | 0.0376816141579 | 1.0 | RAB3GAP2 RAB3GAP1 | Pachygyria |
| HP:0007495 | 0.0397389633075 | 1.0 | RAB3GAP2 RAB3GAP1 | Prematurely aged appearance |
| HP:0012472 | 0.0407881430233 | 1.0 | RAB3GAP2 RAB3GAP1 | Eclabion |
| HP:0001120 | 0.0413178591665 | 1.0 | RAB3GAP2 RAB3GAP1 | Abnormality of corneal size |
| HP:0000823 | 0.0451215628267 | 1.0 | RAB3GAP2 RAB3GAP1 | Delayed puberty |
| HP:0001339 | 0.0479410197177 | 1.0 | RAB3GAP2 RAB3GAP1 | Lissencephaly |
| HP:0003992 | 0.0499436884913 | 0.5 | RAB3GAP2 | Slender ulna |
| HP:0003969 | 0.0499436884913 | 0.5 | RAB3GAP2 | Slender forearm bones |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RAB3GAP2 | RAB3GAP1 | 0.999 | 0.936 | bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction |
Related Complexes