hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01069.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ERCC4 | DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein) | 5 | UniProt NCBI |
| SLX4 | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | 5 | UniProt NCBI |
| ERCC1 | DNA excision repair protein ERCC-1 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0070522 | 9.61200410764e-08 | 1.0 | ERCC4 SLX4 ERCC1 | ERCC4-ERCC1 complex |
| KEGG:03460 | 9.62454150431e-07 | 1.0 | ERCC4 SLX4 ERCC1 | Fanconi anemia pathway |
| REAC:R-HSA-6783310 | 3.05391101381e-06 | 1.0 | ERCC4 SLX4 ERCC1 | Fanconi Anemia Pathway |
| CORUM:2220 | 3.41752350426e-06 | 0.666666666667 | ERCC4 ERCC1 | RAD52-ERCC4-ERCC1 complex |
| WP:WP5114 | 4.82119522161e-06 | 1.0 | ERCC4 SLX4 ERCC1 | Nucleotide excision repair in xeroderma pigmentosum |
| CORUM:368 | 1.02521027753e-05 | 0.666666666667 | ERCC4 ERCC1 | ERCC1-ERCC4-MSH2 complex |
| CORUM:531 | 1.02521027753e-05 | 0.666666666667 | ERCC4 ERCC1 | XPA-ERCC1-ERCC4 complex |
| GO:0000109 | 1.58598067776e-05 | 1.0 | ERCC4 SLX4 ERCC1 | nucleotide-excision repair complex |
| REAC:R-HSA-5693567 | 0.000141203606556 | 1.0 | ERCC4 SLX4 ERCC1 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 0.00016307931474 | 1.0 | ERCC4 SLX4 ERCC1 | Homology Directed Repair |
| HP:0006313 | 0.000189776464884 | 0.666666666667 | ERCC4 ERCC1 | Widely spaced primary teeth |
| HP:0006334 | 0.000265674927589 | 0.666666666667 | ERCC4 ERCC1 | Hypoplasia of the primary teeth |
| REAC:R-HSA-5693532 | 0.000300937850546 | 1.0 | ERCC4 SLX4 ERCC1 | DNA Double-Strand Break Repair |
| GO:0032205 | 0.000686297093286 | 1.0 | ERCC4 SLX4 ERCC1 | negative regulation of telomere maintenance |
| HP:0001034 | 0.000734362309502 | 1.0 | ERCC4 SLX4 ERCC1 | Hypermelanotic macule |
| HP:0002818 | 0.000884463712025 | 1.0 | ERCC4 SLX4 ERCC1 | Abnormal morphology of the radius |
| WP:WP4753 | 0.00102095428698 | 0.666666666667 | ERCC4 ERCC1 | Nucleotide excision repair |
| HP:0000025 | 0.00105373976382 | 1.0 | ERCC4 SLX4 ERCC1 | Functional abnormality of male internal genitalia |
| HP:0040072 | 0.00110338533207 | 1.0 | ERCC4 SLX4 ERCC1 | Abnormal forearm bone morphology |
| HP:0002973 | 0.00112027388307 | 1.0 | ERCC4 SLX4 ERCC1 | Abnormal forearm morphology |
| HP:0007400 | 0.00113733389144 | 1.0 | ERCC4 SLX4 ERCC1 | Irregular hyperpigmentation |
| HP:0012733 | 0.00118955132024 | 1.0 | ERCC4 SLX4 ERCC1 | Macule |
| KEGG:03420 | 0.00125862804941 | 0.666666666667 | ERCC4 ERCC1 | Nucleotide excision repair |
| HP:0000674 | 0.00132788970801 | 0.666666666667 | ERCC4 ERCC1 | Anodontia |
| GO:1990599 | 0.00140460216025 | 0.666666666667 | ERCC4 ERCC1 | 3' overhang single-stranded DNA endodeoxyribonuclease activity |
| GO:0061819 | 0.00140460216025 | 0.666666666667 | ERCC4 ERCC1 | telomeric DNA-containing double minutes formation |
| GO:1905765 | 0.00140460216025 | 0.666666666667 | ERCC4 ERCC1 | negative regulation of protection from non-homologous end joining at telomere |
| GO:1905764 | 0.00140460216025 | 0.666666666667 | ERCC4 ERCC1 | regulation of protection from non-homologous end joining at telomere |
| HP:0000680 | 0.00151751896202 | 0.666666666667 | ERCC4 ERCC1 | Delayed eruption of primary teeth |
| HP:0002827 | 0.00153673431077 | 1.0 | ERCC4 SLX4 ERCC1 | Hip dislocation |
| HP:0012874 | 0.00207086212173 | 1.0 | ERCC4 SLX4 ERCC1 | Abnormal male reproductive system physiology |
| HP:0000568 | 0.0021224171016 | 1.0 | ERCC4 SLX4 ERCC1 | Microphthalmia |
| REAC:R-HSA-73894 | 0.00220643087689 | 1.0 | ERCC4 SLX4 ERCC1 | DNA Repair |
| HP:0200007 | 0.00244981062097 | 1.0 | ERCC4 SLX4 ERCC1 | Abnormal size of the palpebral fissures |
| HP:0000953 | 0.00271630473377 | 1.0 | ERCC4 SLX4 ERCC1 | Hyperpigmentation of the skin |
| HP:0005522 | 0.00292042386749 | 0.666666666667 | ERCC4 SLX4 | Pyridoxine-responsive sideroblastic anemia |
| HP:0100887 | 0.00293644474028 | 1.0 | ERCC4 SLX4 ERCC1 | Abnormality of globe size |
| HP:0030311 | 0.00293644474028 | 1.0 | ERCC4 SLX4 ERCC1 | Lower extremity joint dislocation |
| HP:0010469 | 0.00319841341764 | 0.666666666667 | ERCC4 SLX4 | Absent testis |
| HP:0007700 | 0.00330589727222 | 1.0 | ERCC4 SLX4 ERCC1 | Ocular anterior segment dysgenesis |
| REAC:R-HSA-5685938 | 0.00405087414568 | 0.666666666667 | ERCC4 ERCC1 | HDR through Single Strand Annealing (SSA) |
| GO:0000110 | 0.00421361424067 | 0.666666666667 | ERCC4 ERCC1 | nucleotide-excision repair factor 1 complex |
| GO:1904506 | 0.00421361424067 | 0.666666666667 | ERCC4 ERCC1 | negative regulation of telomere maintenance in response to DNA damage |
| HP:0012848 | 0.00443651401809 | 0.666666666667 | ERCC4 SLX4 | Small intestinal stenosis |
| HP:0100867 | 0.00443651401809 | 0.666666666667 | ERCC4 SLX4 | Duodenal stenosis |
| HP:0010293 | 0.00443651401809 | 0.666666666667 | ERCC4 SLX4 | Aplasia/Hypoplasia of the uvula |
| HP:0100760 | 0.0047775661087 | 0.666666666667 | ERCC4 SLX4 | Clubbing of toes |
| HP:0005328 | 0.0047775661087 | 0.666666666667 | ERCC4 ERCC1 | Progeroid facial appearance |
| HP:0002245 | 0.0047775661087 | 0.666666666667 | ERCC4 SLX4 | Meckel diverticulum |
| HP:0001384 | 0.00490874658422 | 1.0 | ERCC4 SLX4 ERCC1 | Abnormal hip joint morphology |
| HP:0100587 | 0.00549749049527 | 0.666666666667 | ERCC4 SLX4 | Abnormal preputium morphology |
| HP:0001373 | 0.0055729611805 | 1.0 | ERCC4 SLX4 ERCC1 | Joint dislocation |
| REAC:R-HSA-5696400 | 0.005581186855 | 0.666666666667 | ERCC4 ERCC1 | Dual Incision in GG-NER |
| REAC:R-HSA-5696395 | 0.00585997836812 | 0.666666666667 | ERCC4 ERCC1 | Formation of Incision Complex in GG-NER |
| HP:0000026 | 0.00626783027637 | 0.666666666667 | ERCC4 ERCC1 | Male hypogonadism |
| HP:0001924 | 0.00626783027637 | 0.666666666667 | ERCC4 SLX4 | Sideroblastic anemia |
| HP:0001172 | 0.00640244769281 | 1.0 | ERCC4 SLX4 ERCC1 | Abnormal thumb morphology |
| HP:0000135 | 0.00645685942958 | 1.0 | ERCC4 SLX4 ERCC1 | Hypogonadism |
| WP:WP4946 | 0.0071317033437 | 0.666666666667 | ERCC4 ERCC1 | DNA repair pathways full network |
| GO:0006289 | 0.00731242824493 | 1.0 | ERCC4 SLX4 ERCC1 | nucleotide-excision repair |
| HP:0040070 | 0.00823605004937 | 1.0 | ERCC4 SLX4 ERCC1 | Abnormal upper limb bone morphology |
| HP:0040012 | 0.00841415615575 | 0.666666666667 | ERCC4 SLX4 | Chromosome breakage |
| HP:0001549 | 0.00841415615575 | 0.666666666667 | ERCC4 SLX4 | Abnormal ileum morphology |
| GO:1904431 | 0.00842684400117 | 0.666666666667 | ERCC1 SLX4 | positive regulation of t-circle formation |
| HP:0000554 | 0.00936084070842 | 0.666666666667 | ERCC4 ERCC1 | Uveitis |
| HP:0008056 | 0.00965862232757 | 1.0 | ERCC4 SLX4 ERCC1 | Aplasia/Hypoplasia affecting the eye |
| GO:2001251 | 0.0101882437539 | 1.0 | ERCC4 SLX4 ERCC1 | negative regulation of chromosome organization |
| HP:0001000 | 0.0107692028076 | 1.0 | ERCC4 SLX4 ERCC1 | Abnormality of skin pigmentation |
| HP:0000813 | 0.0125029572242 | 0.666666666667 | ERCC4 SLX4 | Bicornuate uterus |
| REAC:R-HSA-6782135 | 0.0137071284674 | 0.666666666667 | ERCC4 ERCC1 | Dual incision in TC-NER |
| HP:0007874 | 0.0142438401108 | 0.666666666667 | ERCC4 SLX4 | Almond-shaped palpebral fissure |
| HP:0100026 | 0.0148492820647 | 0.666666666667 | ERCC4 SLX4 | Arteriovenous malformation |
| GO:0032204 | 0.0155426106421 | 1.0 | ERCC4 SLX4 ERCC1 | regulation of telomere maintenance |
| HP:0003272 | 0.0159610532209 | 1.0 | ERCC4 SLX4 ERCC1 | Abnormal hip bone morphology |
| HP:0003022 | 0.0160978770685 | 0.666666666667 | ERCC4 SLX4 | Hypoplasia of the ulna |
| HP:0003220 | 0.0167410266547 | 0.666666666667 | ERCC4 SLX4 | Abnormality of chromosome stability |
| HP:0200005 | 0.0173967419879 | 0.666666666667 | ERCC4 SLX4 | Abnormal shape of the palpebral fissure |
| HP:0009777 | 0.0173967419879 | 0.666666666667 | ERCC4 SLX4 | Absent thumb |
| HP:0000553 | 0.0173987795596 | 1.0 | ERCC4 SLX4 ERCC1 | Abnormal uvea morphology |
| HP:0006495 | 0.0187458629677 | 0.666666666667 | ERCC4 SLX4 | Aplasia/Hypoplasia of the ulna |
| HP:0000331 | 0.0194392651505 | 0.666666666667 | ERCC4 ERCC1 | Short chin |
| REAC:R-HSA-6781827 | 0.019882541548 | 0.666666666667 | ERCC4 ERCC1 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| HP:0007565 | 0.0201452261528 | 0.666666666667 | ERCC4 SLX4 | Multiple cafe-au-lait spots |
| HP:0001511 | 0.0218534403487 | 1.0 | ERCC4 SLX4 ERCC1 | Intrauterine growth retardation |
| GO:0051053 | 0.0219076797621 | 1.0 | ERCC4 SLX4 ERCC1 | negative regulation of DNA metabolic process |
| HP:0008373 | 0.0219766740349 | 1.0 | ERCC4 SLX4 ERCC1 | Puberty and gonadal disorders |
| HP:0002860 | 0.022338444757 | 0.666666666667 | ERCC4 SLX4 | Squamous cell carcinoma |
| HP:0002644 | 0.0223491530492 | 1.0 | ERCC4 SLX4 ERCC1 | Abnormal pelvic girdle bone morphology |
| REAC:R-HSA-5696399 | 0.0231174657298 | 0.666666666667 | ERCC4 ERCC1 | Global Genome Nucleotide Excision Repair (GG-NER) |
| HP:0000528 | 0.024644630388 | 0.666666666667 | ERCC4 ERCC1 | Anophthalmia |
| HP:0001199 | 0.0254384546332 | 0.666666666667 | ERCC4 SLX4 | Triphalangeal thumb |
| HP:0000072 | 0.0270637362845 | 0.666666666667 | ERCC4 SLX4 | Hydroureter |
| GO:0031848 | 0.0294899169624 | 0.666666666667 | ERCC4 ERCC1 | protection from non-homologous end joining at telomere |
| GO:1904429 | 0.0294899169624 | 0.666666666667 | ERCC1 SLX4 | regulation of t-circle formation |
| GO:1904354 | 0.0294899169624 | 0.666666666667 | ERCC4 ERCC1 | negative regulation of telomere capping |
| HP:0009821 | 0.0304647837379 | 0.666666666667 | ERCC4 SLX4 | Forearm undergrowth |
| HP:0006501 | 0.0313463863633 | 0.666666666667 | ERCC4 SLX4 | Aplasia/Hypoplasia of the radius |
| HP:0006481 | 0.0322405218297 | 0.666666666667 | ERCC4 ERCC1 | Abnormality of primary teeth |
| HP:0001780 | 0.0327588054209 | 1.0 | ERCC4 SLX4 ERCC1 | Abnormal toe morphology |
| HP:0100491 | 0.033570972141 | 1.0 | ERCC4 SLX4 ERCC1 | Abnormality of lower limb joint |
| HP:0002172 | 0.0340663843581 | 0.666666666667 | ERCC4 ERCC1 | Postural instability |
| HP:0008572 | 0.0349981079563 | 0.666666666667 | ERCC4 SLX4 | External ear malformation |
| HP:0009380 | 0.0359423574679 | 0.666666666667 | ERCC4 SLX4 | Aplasia of the fingers |
| HP:0011314 | 0.0383682142819 | 1.0 | ERCC4 SLX4 ERCC1 | Abnormal long bone morphology |
| HP:0002246 | 0.0388502441646 | 0.666666666667 | ERCC4 SLX4 | Abnormal duodenum morphology |
| HP:0009824 | 0.0388502441646 | 0.666666666667 | ERCC4 SLX4 | Upper limb undergrowth |
| REAC:R-HSA-5696398 | 0.0392065258044 | 0.666666666667 | ERCC4 ERCC1 | Nucleotide Excision Repair |
| HP:0040069 | 0.0396349906946 | 1.0 | ERCC4 SLX4 ERCC1 | Abnormal lower limb bone morphology |
| HP:0000028 | 0.0407427395301 | 1.0 | ERCC4 SLX4 ERCC1 | Cryptorchidism |
| HP:0005344 | 0.0408514331117 | 0.666666666667 | ERCC4 SLX4 | Abnormal carotid artery morphology |
| HP:0000080 | 0.0424427653377 | 1.0 | ERCC4 SLX4 ERCC1 | Abnormality of reproductive system physiology |
| HP:0002575 | 0.045003983416 | 0.666666666667 | ERCC4 SLX4 | Tracheoesophageal fistula |
| GO:0000723 | 0.0458676185213 | 1.0 | ERCC4 SLX4 ERCC1 | telomere maintenance |
| HP:0006297 | 0.0460733968082 | 0.666666666667 | ERCC4 ERCC1 | Enamel hypoplasia |
| HP:0000027 | 0.047155317063 | 0.666666666667 | ERCC4 SLX4 | Azoospermia |
| GO:0000781 | 0.0478331772413 | 1.0 | ERCC4 SLX4 ERCC1 | chromosome, telomeric region |
| HP:0006503 | 0.0482497424485 | 0.666666666667 | ERCC4 SLX4 | Aplasia/hypoplasia involving forearm bones |
| HP:0000518 | 0.0490800611352 | 1.0 | ERCC4 SLX4 ERCC1 | Cataract |
| HP:0100699 | 0.0493566712329 | 0.666666666667 | ERCC4 ERCC1 | Scarring |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ERCC4 | ERCC1 | 0.999 | 0.24 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo fraction |
| ERCC4 | SLX4 | 0.968 | 0.166 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| SLX4 | ERCC1 | 0.682 | 0.184 | bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes