hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_01074.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IKBKG | NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) | 5 | UniProt NCBI |
| CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | 5 | UniProt NCBI |
| IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2121 | 2.33868713081e-10 | 1.0 | IKBKB IKBKG CHUK | I-kappa-B kinase complex |
| CORUM:5844 | 2.33868713081e-10 | 1.0 | IKBKB IKBKG CHUK | I-kappa-B kinase complex |
| REAC:R-HSA-5603027 | 4.66602141148e-10 | 1.0 | IKBKB IKBKG CHUK | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) |
| REAC:R-HSA-5602636 | 4.66602141148e-10 | 1.0 | IKBKB IKBKG CHUK | IKBKB deficiency causes SCID |
| CORUM:2118 | 9.35474852325e-10 | 1.0 | IKBKB IKBKG CHUK | CHUK-ERC1-IKBKB-IKBKG |
| CORUM:2727 | 2.33868713081e-09 | 1.0 | IKBKB IKBKG CHUK | SRC-3 complex |
| WP:WP4479 | 2.71306567554e-09 | 1.0 | IKBKB IKBKG CHUK | Supression of HMGB1 mediated inflammation by THBD |
| WP:WP4480 | 4.34090508087e-09 | 1.0 | IKBKB IKBKG CHUK | Altered glycosylation of MUC1 in tumor microenvironment |
| WP:WP4562 | 4.34090508087e-09 | 1.0 | IKBKB IKBKG CHUK | Canonical NF kB pathway |
| WP:WP288 | 6.51135762131e-09 | 1.0 | IKBKB IKBKG CHUK | Nod like receptor NLR signaling pathway |
| REAC:R-HSA-5603029 | 1.63310749402e-08 | 1.0 | IKBKB IKBKG CHUK | IkBA variant leads to EDA-ID |
| WP:WP3849 | 1.70535556749e-08 | 1.0 | IKBKB IKBKG CHUK | MAPK and NFkB signaling pathways inhibited by Yersinia YopJ |
| CORUM:5194 | 2.80642455698e-08 | 1.0 | IKBKB IKBKG CHUK | TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2) |
| WP:WP4961 | 6.32531883213e-08 | 1.0 | IKBKB IKBKG CHUK | STING pathway in Kawasaki like disease and COVID 19 |
| CORUM:5266 | 6.68864519413e-08 | 1.0 | IKBKB IKBKG CHUK | TNF-alpha/NF-kappa B signaling complex 6 |
| REAC:R-HSA-933543 | 7.69893532894e-08 | 1.0 | IKBKB IKBKG CHUK | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| CORUM:6344 | 8.51282115616e-08 | 1.0 | IKBKB IKBKG CHUK | TNF-R1-associated signaling complex |
| WP:WP712 | 8.83684248606e-08 | 1.0 | IKBKB IKBKG CHUK | Estrogen signaling pathway |
| WP:WP4482 | 8.83684248606e-08 | 1.0 | IKBKB IKBKG CHUK | Vitamin D in inflammatory diseases |
| WP:WP262 | 1.19374889724e-07 | 1.0 | IKBKB IKBKG CHUK | Ebstein Barr virus LMP1 signaling |
| REAC:R-HSA-975144 | 1.33448212368e-07 | 1.0 | IKBKB IKBKG CHUK | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation |
| REAC:R-HSA-937039 | 1.33448212368e-07 | 1.0 | IKBKB IKBKG CHUK | IRAK1 recruits IKK complex |
| KEGG:01523 | 1.35821797173e-07 | 1.0 | IKBKB IKBKG CHUK | Antifolate resistance |
| REAC:R-HSA-5684264 | 1.69843179378e-07 | 1.0 | IKBKB IKBKG CHUK | MAP3K8 (TPL2)-dependent MAPK1/3 activation |
| WP:WP3851 | 1.78287172964e-07 | 1.0 | IKBKB IKBKG CHUK | TLR4 signaling and tolerance |
| WP:WP5113 | 2.01542021612e-07 | 1.0 | IKBKB IKBKG CHUK | Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway |
| WP:WP1433 | 2.01542021612e-07 | 1.0 | IKBKB IKBKG CHUK | Nucleotide binding oligomerization domain NOD pathway |
| WP:WP3858 | 2.26734774313e-07 | 1.0 | IKBKB IKBKG CHUK | Toll like receptor signaling related to MyD88 |
| WP:WP4481 | 2.53942947231e-07 | 1.0 | IKBKB IKBKG CHUK | Resistin as a regulator of inflammation |
| REAC:R-HSA-9758274 | 2.61297199043e-07 | 1.0 | IKBKB IKBKG CHUK | Regulation of NF-kappa B signaling |
| REAC:R-HSA-1810476 | 2.61297199043e-07 | 1.0 | IKBKB IKBKG CHUK | RIP-mediated NFkB activation via ZBP1 |
| WP:WP4880 | 2.83244056527e-07 | 1.0 | IKBKB IKBKG CHUK | Host pathogen interaction of human coronaviruses interferon induction |
| WP:WP4329 | 3.48435148902e-07 | 1.0 | IKBKB IKBKG CHUK | miRNA role in immune response in sepsis |
| CORUM:5233 | 3.60157818145e-07 | 1.0 | IKBKB IKBKG CHUK | TNF-alpha/NF-kappa B signaling complex 5 |
| REAC:R-HSA-1606322 | 3.80747347177e-07 | 1.0 | IKBKB IKBKG CHUK | ZBP1(DAI) mediated induction of type I IFNs |
| WP:WP4136 | 4.22928180736e-07 | 1.0 | IKBKB IKBKG CHUK | Fibrin complement receptor 3 signaling pathway |
| REAC:R-HSA-168927 | 4.52137474772e-07 | 1.0 | IKBKB IKBKG CHUK | TICAM1, RIP1-mediated IKK complex recruitment |
| REAC:R-HSA-937041 | 5.31926440908e-07 | 1.0 | IKBKB IKBKG CHUK | IKK complex recruitment mediated by RIP1 |
| REAC:R-HSA-933542 | 6.20580847727e-07 | 1.0 | IKBKB IKBKG CHUK | TRAF6 mediated NF-kB activation |
| WP:WP2795 | 8.89885541579e-07 | 1.0 | IKBKB IKBKG CHUK | Cardiac hypertrophic response |
| WP:WP2018 | 1.17669534156e-06 | 1.0 | IKBKB IKBKG CHUK | RANKL RANK signaling pathway |
| WP:WP195 | 1.34071954069e-06 | 1.0 | IKBKB IKBKG CHUK | IL 1 signaling pathway |
| REAC:R-HSA-5260271 | 1.36481126286e-06 | 1.0 | IKBKB IKBKG CHUK | Diseases of Immune System |
| REAC:R-HSA-5602358 | 1.36481126286e-06 | 1.0 | IKBKB IKBKG CHUK | Diseases associated with the TLR signaling cascade |
| WP:WP3863 | 1.42815777161e-06 | 1.0 | IKBKB IKBKG CHUK | T cell antigen receptor TCR pathway during Staphylococcus aureus infection |
| KEGG:05221 | 1.69824261704e-06 | 1.0 | IKBKB IKBKG CHUK | Acute myeloid leukemia |
| WP:WP5072 | 1.81589361472e-06 | 1.0 | IKBKB IKBKG CHUK | Modulators of TCR signaling and T cell activation |
| GO:0008385 | 1.92240082153e-06 | 1.0 | IKBKB IKBKG CHUK | IkappaB kinase complex |
| WP:WP3865 | 1.92271088618e-06 | 1.0 | IKBKB IKBKG CHUK | Novel intracellular components of RIG I like receptor pathway |
| KEGG:05120 | 2.07446899521e-06 | 1.0 | IKBKB IKBKG CHUK | Epithelial cell signaling in Helicobacter pylori infection |
| KEGG:04920 | 2.07446899521e-06 | 1.0 | IKBKB IKBKG CHUK | Adipocytokine signaling pathway |
| KEGG:04622 | 2.28180619251e-06 | 1.0 | IKBKB IKBKG CHUK | RIG-I-like receptor signaling pathway |
| REAC:R-HSA-168638 | 2.31434662009e-06 | 1.0 | IKBKB IKBKG CHUK | NOD1/2 Signaling Pathway |
| REAC:R-HSA-5357956 | 2.31434662009e-06 | 1.0 | IKBKB IKBKG CHUK | TNFR1-induced NF-kappa-B signaling pathway |
| WP:WP5293 | 2.51997291561e-06 | 1.0 | IKBKB IKBKG CHUK | Acute myeloid leukemia |
| KEGG:04662 | 2.61801737967e-06 | 1.0 | IKBKB IKBKG CHUK | B cell receptor signaling pathway |
| WP:WP69 | 2.78980667608e-06 | 1.0 | IKBKB IKBKG CHUK | T cell receptor signaling pathway |
| KEGG:04623 | 2.85957122202e-06 | 1.0 | IKBKB IKBKG CHUK | Cytosolic DNA-sensing pathway |
| WP:WP3303 | 3.07824431547e-06 | 1.0 | IKBKB IKBKG CHUK | RAC1 PAK1 p38 MMP2 pathway |
| KEGG:05212 | 3.11554307054e-06 | 1.0 | IKBKB IKBKG CHUK | Pancreatic cancer |
| REAC:R-HSA-445989 | 3.3315392878e-06 | 1.0 | IKBKB IKBKG CHUK | TAK1-dependent IKK and NF-kappa-B activation |
| WP:WP4655 | 3.38590596308e-06 | 1.0 | IKBKB IKBKG CHUK | Cytosolic DNA sensing pathway |
| KEGG:05220 | 3.38635083845e-06 | 1.0 | IKBKB IKBKG CHUK | Chronic myeloid leukemia |
| KEGG:04658 | 3.38635083845e-06 | 1.0 | IKBKB IKBKG CHUK | Th1 and Th2 cell differentiation |
| CORUM:5829 | 3.41752350426e-06 | 0.666666666667 | IKBKG CHUK | IKBKG-CHUK complex |
| CORUM:5828 | 3.41752350426e-06 | 0.666666666667 | IKBKG IKBKB | IKBKG-IKBKB complex |
| CORUM:6152 | 3.41752350426e-06 | 0.666666666667 | IKBKG CHUK | IKBKG-CHUK complex |
| CORUM:2101 | 3.41752350426e-06 | 0.666666666667 | CHUK IKBKB | IKKA-IKKB complex |
| KEGG:04657 | 3.82129402432e-06 | 1.0 | IKBKB IKBKG CHUK | IL-17 signaling pathway |
| WP:WP2034 | 3.88479998273e-06 | 1.0 | IKBKB IKBKG CHUK | Leptin signaling pathway |
| WP:WP1544 | 4.06138180013e-06 | 1.0 | IKBKB IKBKG CHUK | MicroRNAs in cardiomyocyte hypertrophy |
| KEGG:04064 | 4.29196879067e-06 | 1.0 | IKBKB IKBKG CHUK | NF-kappa B signaling pathway |
| KEGG:05235 | 4.29196879067e-06 | 1.0 | IKBKB IKBKG CHUK | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| WP:WP254 | 4.82119522161e-06 | 1.0 | IKBKB IKBKG CHUK | Apoptosis |
| WP:WP5098 | 5.02490769576e-06 | 1.0 | IKBKB IKBKG CHUK | T cell activation SARS CoV 2 |
| KEGG:04625 | 5.159661118e-06 | 1.0 | IKBKB IKBKG CHUK | C-type lectin receptor signaling pathway |
| KEGG:05222 | 5.34615489335e-06 | 1.0 | IKBKB IKBKG CHUK | Small cell lung cancer |
| WP:WP23 | 5.44938619974e-06 | 1.0 | IKBKB IKBKG CHUK | B cell receptor signaling pathway |
| KEGG:04620 | 5.53708899668e-06 | 1.0 | IKBKB IKBKG CHUK | Toll-like receptor signaling pathway |
| KEGG:05142 | 5.73251566715e-06 | 1.0 | IKBKB IKBKG CHUK | Chagas disease |
| KEGG:04659 | 6.13705566612e-06 | 1.0 | IKBKB IKBKG CHUK | Th17 cell differentiation |
| KEGG:05215 | 6.13705566612e-06 | 1.0 | IKBKB IKBKG CHUK | Prostate cancer |
| REAC:R-HSA-5357905 | 6.17967875736e-06 | 1.0 | IKBKB IKBKG CHUK | Regulation of TNFR1 signaling |
| KEGG:05145 | 6.34627347292e-06 | 1.0 | IKBKB IKBKG CHUK | Toxoplasmosis |
| WP:WP4263 | 6.61367895536e-06 | 1.0 | IKBKB IKBKG CHUK | Pancreatic adenocarcinoma pathway |
| REAC:R-HSA-168643 | 7.08302050262e-06 | 1.0 | IKBKB IKBKG CHUK | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| WP:WP75 | 7.12226249528e-06 | 1.0 | IKBKB IKBKG CHUK | Toll like receptor signaling pathway |
| KEGG:04668 | 7.23068232913e-06 | 1.0 | IKBKB IKBKG CHUK | TNF signaling pathway |
| WP:WP231 | 7.3860499951e-06 | 1.0 | IKBKB IKBKG CHUK | TNF alpha signaling pathway |
| GO:1990459 | 8.07408345042e-06 | 1.0 | IKBKB IKBKG CHUK | transferrin receptor binding |
| WP:WP4658 | 8.80304543936e-06 | 1.0 | IKBKB IKBKG CHUK | Small cell lung cancer |
| KEGG:04660 | 9.23854640457e-06 | 1.0 | IKBKB IKBKG CHUK | T cell receptor signaling pathway |
| CORUM:2100 | 1.02521027753e-05 | 0.666666666667 | CHUK IKBKB | CHUK-IKBKB-MAP3K14 complex |
| REAC:R-HSA-75893 | 1.09306217585e-05 | 1.0 | IKBKB IKBKG CHUK | TNF signaling |
| KEGG:04380 | 1.28981080119e-05 | 1.0 | IKBKB IKBKG CHUK | Osteoclast differentiation |
| KEGG:05135 | 1.28981080119e-05 | 1.0 | IKBKB IKBKG CHUK | Yersinia infection |
| REAC:R-HSA-450294 | 1.29342113526e-05 | 1.0 | IKBKB IKBKG CHUK | MAP kinase activation |
| KEGG:05418 | 1.35889708072e-05 | 1.0 | IKBKB IKBKG CHUK | Fluid shear stress and atherosclerosis |
| KEGG:04210 | 1.46708436608e-05 | 1.0 | IKBKB IKBKG CHUK | Apoptosis |
| REAC:R-HSA-1834949 | 1.51687690066e-05 | 1.0 | IKBKB IKBKG CHUK | Cytosolic sensors of pathogen-associated DNA |
| KEGG:05162 | 1.62006150102e-05 | 1.0 | IKBKB IKBKG CHUK | Measles |
| KEGG:04936 | 1.62006150102e-05 | 1.0 | IKBKB IKBKG CHUK | Alcoholic liver disease |
| REAC:R-HSA-448424 | 1.76468929782e-05 | 1.0 | IKBKB IKBKG CHUK | Interleukin-17 signaling |
| KEGG:05160 | 1.91271045869e-05 | 1.0 | IKBKB IKBKG CHUK | Hepatitis C |
| REAC:R-HSA-1169091 | 2.03811815253e-05 | 1.0 | IKBKB IKBKG CHUK | Activation of NF-kappaB in B cells |
| WP:WP3929 | 2.23231043784e-05 | 1.0 | IKBKB IKBKG CHUK | Chemokine signaling pathway |
| KEGG:04062 | 2.28801742777e-05 | 1.0 | IKBKB IKBKG CHUK | Chemokine signaling pathway |
| WP:WP2380 | 2.34580185085e-05 | 1.0 | IKBKB IKBKG CHUK | Brain derived neurotrophic factor BDNF signaling pathway |
| WP:WP4630 | 2.34580185085e-05 | 1.0 | IKBKB IKBKG CHUK | Measles virus infection |
| KEGG:05164 | 2.54584376622e-05 | 1.0 | IKBKB IKBKG CHUK | Influenza A |
| KEGG:04621 | 2.65416687338e-05 | 1.0 | IKBKB IKBKG CHUK | NOD-like receptor signaling pathway |
| KEGG:05161 | 2.7655198514e-05 | 1.0 | IKBKB IKBKG CHUK | Hepatitis B |
| REAC:R-HSA-1168372 | 3.02470171978e-05 | 1.0 | IKBKB IKBKG CHUK | Downstream signaling events of B Cell Receptor (BCR) |
| REAC:R-HSA-168928 | 3.1507309581e-05 | 1.0 | IKBKB IKBKG CHUK | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| REAC:R-HSA-2871837 | 3.1507309581e-05 | 1.0 | IKBKB IKBKG CHUK | FCERI mediated NF-kB activation |
| WP:WP4666 | 3.24963255001e-05 | 1.0 | IKBKB IKBKG CHUK | Hepatitis B infection |
| CORUM:2105 | 3.41705576683e-05 | 0.666666666667 | CHUK IKBKB | IkappaB kinase complex (IKBKB, CHUK, IKBKAP, NFKBIA, RELA, MAP3K14) |
| CORUM:2055 | 3.41705576683e-05 | 0.666666666667 | CHUK IKBKB | CASP8-CHUK-IKBKB-MALT1-BCL10 complex |
| KEGG:05130 | 3.84025683677e-05 | 1.0 | IKBKB IKBKG CHUK | Pathogenic Escherichia coli infection |
| WP:WP4223 | 4.02049202459e-05 | 1.0 | IKBKB IKBKG CHUK | Ras signaling |
| KEGG:05167 | 4.05488661979e-05 | 1.0 | IKBKB IKBKG CHUK | Kaposi sarcoma-associated herpesvirus infection |
| REAC:R-HSA-975871 | 4.132228562e-05 | 1.0 | IKBKB IKBKG CHUK | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168176 | 4.132228562e-05 | 1.0 | IKBKB IKBKG CHUK | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-168142 | 4.132228562e-05 | 1.0 | IKBKB IKBKG CHUK | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-975138 | 4.44597184171e-05 | 1.0 | IKBKB IKBKG CHUK | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-975155 | 4.60862934812e-05 | 1.0 | IKBKB IKBKG CHUK | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168181 | 4.60862934812e-05 | 1.0 | IKBKB IKBKG CHUK | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-1236974 | 4.60862934812e-05 | 1.0 | IKBKB IKBKG CHUK | ER-Phagosome pathway |
| KEGG:05417 | 4.99333165562e-05 | 1.0 | IKBKB IKBKG CHUK | Lipid and atherosclerosis |
| KEGG:05169 | 4.99333165562e-05 | 1.0 | IKBKB IKBKG CHUK | Epstein-Barr virus infection |
| REAC:R-HSA-168138 | 5.29892055573e-05 | 1.0 | IKBKB IKBKG CHUK | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-202424 | 5.29892055573e-05 | 1.0 | IKBKB IKBKG CHUK | Downstream TCR signaling |
| KEGG:04014 | 5.33562348015e-05 | 1.0 | IKBKB IKBKG CHUK | Ras signaling pathway |
| REAC:R-HSA-5607764 | 5.4816419542e-05 | 1.0 | IKBKB IKBKG CHUK | CLEC7A (Dectin-1) signaling |
| REAC:R-HSA-168164 | 5.66851611173e-05 | 1.0 | IKBKB IKBKG CHUK | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-166166 | 6.05490934482e-05 | 1.0 | IKBKB IKBKG CHUK | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 6.05490934482e-05 | 1.0 | IKBKB IKBKG CHUK | TRIF(TICAM1)-mediated TLR4 signaling |
| KEGG:05163 | 6.06642833159e-05 | 1.0 | IKBKB IKBKG CHUK | Human cytomegalovirus infection |
| KEGG:05170 | 6.16221404209e-05 | 1.0 | IKBKB IKBKG CHUK | Human immunodeficiency virus 1 infection |
| WP:WP1434 | 6.22753219356e-05 | 0.666666666667 | CHUK IKBKB | Osteopontin signaling |
| REAC:R-HSA-168188 | 6.4584735367e-05 | 1.0 | IKBKB IKBKG CHUK | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-166058 | 6.4584735367e-05 | 1.0 | IKBKB IKBKG CHUK | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| KEGG:05166 | 6.65629194888e-05 | 1.0 | IKBKB IKBKG CHUK | Human T-cell leukemia virus 1 infection |
| REAC:R-HSA-983705 | 6.66681139272e-05 | 1.0 | IKBKB IKBKG CHUK | Signaling by the B Cell Receptor (BCR) |
| REAC:R-HSA-168179 | 6.87958196908e-05 | 1.0 | IKBKB IKBKG CHUK | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-181438 | 6.87958196908e-05 | 1.0 | IKBKB IKBKG CHUK | Toll Like Receptor 2 (TLR2) Cascade |
| KEGG:05171 | 7.07004693439e-05 | 1.0 | IKBKB IKBKG CHUK | Coronavirus disease - COVID-19 |
| KEGG:05208 | 7.07004693439e-05 | 1.0 | IKBKB IKBKG CHUK | Chemical carcinogenesis - reactive oxygen species |
| REAC:R-HSA-1236975 | 7.096831926e-05 | 1.0 | IKBKB IKBKG CHUK | Antigen processing-Cross presentation |
| REAC:R-HSA-9020702 | 7.31860792369e-05 | 1.0 | IKBKB IKBKG CHUK | Interleukin-1 signaling |
| REAC:R-HSA-202403 | 9.00168850702e-05 | 1.0 | IKBKB IKBKG CHUK | TCR signaling |
| KEGG:05132 | 9.65496558687e-05 | 1.0 | IKBKB IKBKG CHUK | Salmonella infection |
| KEGG:05131 | 0.000100498988056 | 1.0 | IKBKB IKBKG CHUK | Shigellosis |
| WP:WP382 | 0.000103352299006 | 1.0 | IKBKB IKBKG CHUK | MAPK signaling pathway |
| REAC:R-HSA-2454202 | 0.000103499353939 | 1.0 | IKBKB IKBKG CHUK | Fc epsilon receptor (FCERI) signaling |
| REAC:R-HSA-9705671 | 0.00010634796001 | 1.0 | IKBKB IKBKG CHUK | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| KEGG:04010 | 0.000123391020622 | 1.0 | IKBKB IKBKG CHUK | MAPK signaling pathway |
| REAC:R-HSA-5621481 | 0.00013104054532 | 1.0 | IKBKB IKBKG CHUK | C-type lectin receptors (CLRs) |
| REAC:R-HSA-166016 | 0.000141203606556 | 1.0 | IKBKB IKBKG CHUK | Toll Like Receptor 4 (TLR4) Cascade |
| CORUM:5193 | 0.0001537324292 | 0.666666666667 | IKBKG CHUK | TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2) |
| CORUM:5230 | 0.0001537324292 | 0.666666666667 | IKBKG CHUK | CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex |
| CORUM:5286 | 0.0001537324292 | 0.666666666667 | IKBKG CHUK | TNF-alpha/NF-kappa B signaling complex 10 |
| REAC:R-HSA-73887 | 0.000155553488805 | 1.0 | IKBKB IKBKG CHUK | Death Receptor Signaling |
| REAC:R-HSA-446652 | 0.00016307931474 | 1.0 | IKBKB IKBKG CHUK | Interleukin-1 family signaling |
| KEGG:04151 | 0.000201545964825 | 1.0 | IKBKB IKBKG CHUK | PI3K-Akt signaling pathway |
| REAC:R-HSA-168898 | 0.000217987188301 | 1.0 | IKBKB IKBKG CHUK | Toll-like Receptor Cascades |
| KEGG:05165 | 0.000218999274719 | 1.0 | IKBKB IKBKG CHUK | Human papillomavirus infection |
| WP:WP4172 | 0.000254288281733 | 1.0 | IKBKB IKBKG CHUK | PI3K Akt signaling pathway |
| CORUM:5232 | 0.000310824382464 | 0.666666666667 | IKBKG CHUK | TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) |
| KEGG:05010 | 0.000339187774081 | 1.0 | IKBKB IKBKG CHUK | Alzheimer disease |
| KEGG:05168 | 0.000426859438177 | 1.0 | IKBKB IKBKG CHUK | Herpes simplex virus 1 infection |
| WP:WP2112 | 0.000427669224246 | 0.666666666667 | IKBKG IKBKB | IL 17 signaling pathway |
| WP:WP3617 | 0.000492114068528 | 0.666666666667 | CHUK IKBKB | Photodynamic therapy induced NF kB survival signaling |
| WP:WP4496 | 0.000492114068528 | 0.666666666667 | CHUK IKBKB | Signal transduction through IL1R |
| REAC:R-HSA-9705683 | 0.0005085198111 | 1.0 | IKBKB IKBKG CHUK | SARS-CoV-2-host interactions |
| WP:WP2036 | 0.000712521586106 | 0.666666666667 | CHUK IKBKB | TNF related weak inducer of apoptosis TWEAK signaling pathway |
| KEGG:05200 | 0.000767224943957 | 1.0 | IKBKB IKBKG CHUK | Pathways in cancer |
| WP:WP2332 | 0.00079501095268 | 0.666666666667 | CHUK IKBKB | Interleukin 11 signaling pathway |
| WP:WP2637 | 0.00102095428698 | 0.666666666667 | CHUK IKBKB | Interleukin 1 IL 1 structural pathway |
| WP:WP395 | 0.00122198206637 | 0.666666666667 | CHUK IKBKB | IL 4 signaling pathway |
| GO:0008384 | 0.00140460216025 | 0.666666666667 | CHUK IKBKB | IkappaB kinase activity |
| WP:WP4754 | 0.00155728900053 | 0.666666666667 | CHUK IKBKB | IL 18 signaling pathway |
| REAC:R-HSA-9694516 | 0.00156493505479 | 1.0 | IKBKB IKBKG CHUK | SARS-CoV-2 Infection |
| WP:WP5158 | 0.00193308448658 | 0.666666666667 | CHUK IKBKB | Urotensin II mediated signaling pathway |
| WP:WP2324 | 0.00199965110325 | 0.666666666667 | CHUK IKBKB | AGE RAGE pathway |
| REAC:R-HSA-983169 | 0.00319336906176 | 1.0 | IKBKB IKBKG CHUK | Class I MHC mediated antigen processing & presentation |
| REAC:R-HSA-9679506 | 0.00410096621855 | 1.0 | IKBKB IKBKG CHUK | SARS-CoV Infections |
| REAC:R-HSA-449147 | 0.00479274122097 | 1.0 | IKBKB IKBKG CHUK | Signaling by Interleukins |
| KEGG:04068 | 0.00480614790554 | 0.666666666667 | CHUK IKBKB | FoxO signaling pathway |
| WP:WP4659 | 0.00615571812029 | 0.666666666667 | CHUK IKBKB | Gastrin signaling pathway |
| KEGG:04150 | 0.00824863650471 | 0.666666666667 | CHUK IKBKB | mTOR signaling pathway |
| HP:0002728 | 0.0108752751697 | 0.666666666667 | IKBKG IKBKB | Chronic mucocutaneous candidiasis |
| GO:0051092 | 0.0155426106421 | 1.0 | IKBKB IKBKG CHUK | positive regulation of NF-kappaB transcription factor activity |
| HP:0011370 | 0.0160978770685 | 0.666666666667 | IKBKG IKBKB | Recurrent cutaneous fungal infections |
| REAC:R-HSA-1280215 | 0.01747853546 | 1.0 | IKBKB IKBKG CHUK | Cytokine Signaling in Immune system |
| HP:0011108 | 0.0194392651505 | 0.666666666667 | IKBKG IKBKB | Recurrent sinusitis |
| REAC:R-HSA-1280218 | 0.0226639223828 | 1.0 | IKBKB IKBKG CHUK | Adaptive Immune System |
| CORUM:2123 | 0.0249718442456 | 0.333333333333 | IKBKG | IKBKG homodimer complex |
| CORUM:5730 | 0.0249718442456 | 0.333333333333 | IKBKG | IKBKG homotrimer complex |
| CORUM:5827 | 0.0249718442456 | 0.333333333333 | IKBKG | IKBKG homotetramer complex |
| REAC:R-HSA-9824446 | 0.0269033233908 | 1.0 | IKBKB IKBKG CHUK | Viral Infection Pathways |
| WP:WP2059 | 0.0297769620239 | 0.666666666667 | CHUK IKBKB | Alzheimer 39 s disease and miRNA effects |
| WP:WP5124 | 0.0297769620239 | 0.666666666667 | CHUK IKBKB | Alzheimer 39 s disease |
| HP:0010975 | 0.0304647837379 | 0.666666666667 | IKBKG IKBKB | Abnormal B cell count |
| GO:1902554 | 0.0312870733704 | 1.0 | IKBKB IKBKG CHUK | serine/threonine protein kinase complex |
| WP:WP3932 | 0.0343043102958 | 0.666666666667 | IKBKG IKBKB | Focal adhesion PI3K Akt mTOR signaling pathway |
| HP:0002846 | 0.0349981079563 | 0.666666666667 | IKBKG IKBKB | Abnormal B cell morphology |
| GO:1902911 | 0.0458676185213 | 1.0 | IKBKB IKBKG CHUK | protein kinase complex |
| HP:0002841 | 0.047155317063 | 0.666666666667 | IKBKG IKBKB | Recurrent fungal infections |
| HP:0020100 | 0.047155317063 | 0.666666666667 | IKBKG IKBKB | Unusual fungal infection |
| HP:0011839 | 0.0482497424485 | 0.666666666667 | IKBKG IKBKB | Abnormal T cell count |
| CORUM:2124 | 0.0499402709677 | 0.333333333333 | CHUK | IKK-alpha--ER-alpha-AIB1 complex |
| CORUM:4043 | 0.0499402709677 | 0.333333333333 | IKBKG | NEMO-HIF2(alpha)-ARNT complex |
| CORUM:2104 | 0.0499402709677 | 0.333333333333 | IKBKB | IKKB-NIK complex |
| REAC:R-HSA-5663205 | 0.0499835710674 | 1.0 | IKBKB IKBKG CHUK | Infectious disease |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| IKBKG | IKBKB | 1.0 | 0.29 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| CHUK | IKBKG | 0.999 | 0.176 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| CHUK | IKBKB | 0.998 | 0.07 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
Related Complexes