hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01078.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1) | 5 | UniProt NCBI |
| TAB3 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) | 5 | UniProt NCBI |
| TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2) | 5 | UniProt NCBI |
| MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5268 | 3.36110250117e-12 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | TNF-alpha/NF-kappa B signaling complex 7 |
| REAC:R-HSA-937042 | 2.0166615007e-11 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | IRAK2 mediated activation of TAK1 complex |
| REAC:R-HSA-9014325 | 3.1690395011e-11 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | TICAM1,TRAF6-dependent induction of TAK1 complex |
| REAC:R-HSA-9645460 | 3.1690395011e-11 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Alpha-protein kinase 1 signaling pathway |
| REAC:R-HSA-937072 | 6.86625225239e-11 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | TRAF6-mediated induction of TAK1 complex within TLR4 complex |
| REAC:R-HSA-975163 | 6.86625225239e-11 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| REAC:R-HSA-450321 | 2.2855497008e-10 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| REAC:R-HSA-450302 | 4.65272617662e-10 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | activated TAK1 mediates p38 MAPK activation |
| CORUM:2758 | 7.01606139244e-10 | 0.75 | TAB2 TAB1 MAP3K7 | TAK1 complex |
| WP:WP2637 | 2.95203799349e-09 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Interleukin 1 IL 1 structural pathway |
| REAC:R-HSA-5357956 | 3.4532927412e-09 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | TNFR1-induced NF-kappa-B signaling pathway |
| REAC:R-HSA-168638 | 3.4532927412e-09 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | NOD1/2 Signaling Pathway |
| WP:WP195 | 4.65446521978e-09 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | IL 1 signaling pathway |
| REAC:R-HSA-445989 | 5.65673550947e-09 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | TAK1-dependent IKK and NF-kappa-B activation |
| REAC:R-HSA-168643 | 1.5670900333e-08 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| REAC:R-HSA-75893 | 2.81204239973e-08 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | TNF signaling |
| REAC:R-HSA-450294 | 3.52714096473e-08 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | MAP kinase activation |
| KEGG:04064 | 3.71567240638e-08 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | NF-kappa B signaling pathway |
| WP:WP75 | 4.39569245409e-08 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Toll like receptor signaling pathway |
| WP:WP231 | 4.6154770768e-08 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | TNF alpha signaling pathway |
| REAC:R-HSA-448424 | 5.35706921361e-08 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Interleukin-17 signaling |
| KEGG:04668 | 7.47923615054e-08 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | TNF signaling pathway |
| REAC:R-HSA-2871837 | 1.16721486716e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | FCERI mediated NF-kB activation |
| REAC:R-HSA-168142 | 1.67964855448e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-168176 | 1.67964855448e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-975871 | 1.67964855448e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-975138 | 1.85292875346e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-168181 | 1.94443140795e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-975155 | 1.94443140795e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | MyD88 dependent cascade initiated on endosome |
| KEGG:04936 | 2.20397674971e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Alcoholic liver disease |
| REAC:R-HSA-168138 | 2.34473007301e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-5607764 | 2.4537872857e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | CLEC7A (Dectin-1) signaling |
| CORUM:6344 | 2.55240443388e-07 | 0.75 | TAB2 TAB1 MAP3K7 | TNF-R1-associated signaling complex |
| REAC:R-HSA-168164 | 2.56660509194e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-937061 | 2.8038653175e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 2.8038653175e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-168188 | 3.05720601774e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-166058 | 3.05720601774e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-181438 | 3.32733782576e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-168179 | 3.32733782576e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-9020702 | 3.6149867397e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Interleukin-1 signaling |
| KEGG:04621 | 4.2673120168e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | NOD-like receptor signaling pathway |
| REAC:R-HSA-2454202 | 5.75133133858e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Fc epsilon receptor (FCERI) signaling |
| REAC:R-HSA-9705671 | 5.96434361038e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| KEGG:05130 | 6.99464088899e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-5621481 | 7.88857479229e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | C-type lectin receptors (CLRs) |
| WP:WP3851 | 8.03005285051e-07 | 0.75 | TAB2 TAB1 MAP3K7 | TLR4 signaling and tolerance |
| REAC:R-HSA-166016 | 8.71834457148e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-73887 | 9.92449541033e-07 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Death Receptor Signaling |
| REAC:R-HSA-446652 | 1.05724689171e-06 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Interleukin-1 family signaling |
| REAC:R-HSA-168898 | 1.55902386745e-06 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Toll-like Receptor Cascades |
| WP:WP4329 | 1.56886777977e-06 | 0.75 | TAB2 TAB1 MAP3K7 | miRNA role in immune response in sepsis |
| KEGG:05132 | 2.39901597894e-06 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Salmonella infection |
| KEGG:05131 | 2.53104486756e-06 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Shigellosis |
| REAC:R-HSA-9705683 | 4.84045959651e-06 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | SARS-CoV-2-host interactions |
| WP:WP2018 | 5.29411583099e-06 | 0.75 | TAB2 TAB1 MAP3K7 | RANKL RANK signaling pathway |
| KEGG:05140 | 1.2943754201e-05 | 0.75 | TAB2 TAB1 MAP3K7 | Leishmaniasis |
| CORUM:5215 | 1.53774525569e-05 | 0.5 | TAB2 TAB1 | CS-MAP3K7IP1-MAP3K7IP2 complex |
| REAC:R-HSA-9694516 | 2.17403773089e-05 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | SARS-CoV-2 Infection |
| KEGG:04657 | 2.50159815552e-05 | 0.75 | TAB3 MAP3K7 TAB2 | IL-17 signaling pathway |
| KEGG:04620 | 3.62297031734e-05 | 0.75 | TAB2 TAB1 MAP3K7 | Toll-like receptor signaling pathway |
| KEGG:05145 | 4.15157123412e-05 | 0.75 | TAB2 TAB1 MAP3K7 | Toxoplasmosis |
| REAC:R-HSA-9679506 | 7.87049446163e-05 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | SARS-CoV Infections |
| KEGG:05135 | 8.42717414951e-05 | 0.75 | TAB2 TAB1 MAP3K7 | Yersinia infection |
| KEGG:04380 | 8.42717414951e-05 | 0.75 | TAB2 TAB1 MAP3K7 | Osteoclast differentiation |
| REAC:R-HSA-449147 | 9.69133318499e-05 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Signaling by Interleukins |
| WP:WP4666 | 0.000145521073611 | 0.75 | TAB2 TAB1 MAP3K7 | Hepatitis B infection |
| KEGG:05161 | 0.000180381602802 | 0.75 | TAB2 TAB1 MAP3K7 | Hepatitis B |
| KEGG:05417 | 0.000325152133201 | 0.75 | TAB2 TAB1 MAP3K7 | Lipid and atherosclerosis |
| KEGG:05169 | 0.000325152133201 | 0.75 | TAB2 TAB1 MAP3K7 | Epstein-Barr virus infection |
| KEGG:05170 | 0.00040099636109 | 0.75 | TAB2 TAB1 MAP3K7 | Human immunodeficiency virus 1 infection |
| WP:WP382 | 0.000461288756706 | 0.75 | TAB2 TAB1 MAP3K7 | MAPK signaling pathway |
| REAC:R-HSA-1280215 | 0.000544985136876 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Cytokine Signaling in Immune system |
| KEGG:04010 | 0.000800866642312 | 0.75 | TAB2 TAB1 MAP3K7 | MAPK signaling pathway |
| REAC:R-HSA-9824446 | 0.000968971416592 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Viral Infection Pathways |
| WP:WP4496 | 0.00110807642161 | 0.5 | MAP3K7 TAB1 | Signal transduction through IL1R |
| REAC:R-HSA-5663205 | 0.00221430492734 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Infectious disease |
| REAC:R-HSA-168249 | 0.00247124639724 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Innate Immune System |
| KEGG:05168 | 0.00275266829871 | 0.75 | TAB2 TAB1 MAP3K7 | Herpes simplex virus 1 infection |
| GO:0010008 | 0.0147371035162 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | endosome membrane |
| WP:WP366 | 0.0177395403747 | 0.5 | MAP3K7 TAB1 | TGF beta signaling pathway |
| KEGG:05162 | 0.0189154103852 | 0.5 | TAB2 MAP3K7 | Measles |
| WP:WP4630 | 0.01895043011 | 0.5 | TAB2 MAP3K7 | Measles virus infection |
| REAC:R-HSA-1643685 | 0.0193799289378 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Disease |
| GO:0038061 | 0.0291371139957 | 0.75 | TAB3 MAP3K7 TAB2 | non-canonical NF-kappaB signal transduction |
| REAC:R-HSA-168256 | 0.032293648674 | 1.0 | TAB3 MAP3K7 TAB1 TAB2 | Immune System |
| REAC:R-HSA-202424 | 0.0398310607487 | 0.5 | TAB2 MAP3K7 | Downstream TCR signaling |
| CORUM:748 | 0.049938562206 | 0.25 | MAP3K7 | TRAF6-TAK1 complex |
| KEGG:05171 | 0.049994875911 | 0.5 | TAB2 MAP3K7 | Coronavirus disease - COVID-19 |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TAB1 | TAB2 | 0.999 | 0.156 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| TAB1 | MAP3K7 | 0.999 | 0.266 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only | |
| TAB1 | TAB3 | 0.998 | 0.172 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| TAB2 | MAP3K7 | 0.982 | 0.428 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| TAB3 | TAB2 | 0.865 | 0.118 |
mutually_exclusive (O43318)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| TAB3 | MAP3K7 | 0.848 | 0.142 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes