hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01088.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NELFCD | Negative elongation factor C/D (NELF-C/D) (TH1-like protein) | 5 | UniProt NCBI |
| NELFE | Negative elongation factor E (NELF-E) (RNA-binding protein RD) | 5 | UniProt NCBI |
| XYLT1 | Xylosyltransferase 1 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase I) (XT-I) (XylT-I) | 5 | UniProt NCBI |
| TMEM141 | Transmembrane protein 141 | 2 | UniProt NCBI |
| IGHMBP2 | DNA-binding protein SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase IGHMBP2) (Glial factor 1) (GF-1) (Immunoglobulin mu-binding protein 2) | 5 | UniProt NCBI |
| NELFB | Negative elongation factor B (NELF-B) (Cofactor of BRCA1) | 5 | UniProt NCBI |
| NELFA | Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2598 | 1.92263483365e-12 | 0.571428571429 | NELFE NELFA NELFCD NELFB | NELF complex (Negative elongation factor complex) |
| CORUM:281 | 1.92263483365e-12 | 0.571428571429 | NELFE NELFA NELFCD NELFB | NELF complex (Negative elongation factor complex) |
| GO:0032021 | 9.2094208532e-10 | 0.571428571429 | NELFE NELFA NELFCD NELFB | NELF complex |
| REAC:R-HSA-167242 | 2.60340792443e-08 | 0.571428571429 | NELFE NELFA NELFCD NELFB | Abortive elongation of HIV-1 transcript in the absence of Tat |
| WP:WP5365 | 2.91694719803e-08 | 0.571428571429 | NELFE NELFA NELFCD NELFB | 4p16 3 copy number variation |
| WP:WP3414 | 3.94630358564e-08 | 0.571428571429 | NELFE NELFA NELFCD NELFB | Initiation of transcription and translation elongation at the HIV 1 LTR |
| REAC:R-HSA-167238 | 9.74061410063e-08 | 0.571428571429 | NELFE NELFA NELFCD NELFB | Pausing and recovery of Tat-mediated HIV elongation |
| REAC:R-HSA-167243 | 9.74061410063e-08 | 0.571428571429 | NELFE NELFA NELFCD NELFB | Tat-mediated HIV elongation arrest and recovery |
| REAC:R-HSA-167290 | 1.277713074e-07 | 0.571428571429 | NELFE NELFA NELFCD NELFB | Pausing and recovery of HIV elongation |
| REAC:R-HSA-167158 | 1.277713074e-07 | 0.571428571429 | NELFE NELFA NELFCD NELFB | Formation of the HIV-1 Early Elongation Complex |
| REAC:R-HSA-113418 | 1.277713074e-07 | 0.571428571429 | NELFE NELFA NELFCD NELFB | Formation of the Early Elongation Complex |
| REAC:R-HSA-167287 | 1.277713074e-07 | 0.571428571429 | NELFE NELFA NELFCD NELFB | HIV elongation arrest and recovery |
| KEGG:03250 | 3.76433946347e-07 | 0.571428571429 | NELFE NELFA NELFCD NELFB | Viral life cycle - HIV-1 |
| REAC:R-HSA-167246 | 3.97050332478e-07 | 0.571428571429 | NELFE NELFA NELFCD NELFB | Tat-mediated elongation of the HIV-1 transcript |
| REAC:R-HSA-167200 | 3.97050332478e-07 | 0.571428571429 | NELFE NELFA NELFCD NELFB | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| REAC:R-HSA-167169 | 3.97050332478e-07 | 0.571428571429 | NELFE NELFA NELFCD NELFB | HIV Transcription Elongation |
| REAC:R-HSA-167152 | 4.81392295814e-07 | 0.571428571429 | NELFE NELFA NELFCD NELFB | Formation of HIV elongation complex in the absence of HIV Tat |
| GO:0034244 | 9.20349554216e-07 | 0.571428571429 | NELFE NELFA NELFCD NELFB | negative regulation of transcription elongation by RNA polymerase II |
| REAC:R-HSA-112382 | 1.39776635892e-06 | 0.571428571429 | NELFE NELFA NELFCD NELFB | Formation of RNA Pol II elongation complex |
| REAC:R-HSA-75955 | 1.39776635892e-06 | 0.571428571429 | NELFE NELFA NELFCD NELFB | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-6796648 | 1.84539860471e-06 | 0.571428571429 | NELFE NELFA NELFCD NELFB | TP53 Regulates Transcription of DNA Repair Genes |
| GO:0032785 | 2.81160701714e-06 | 0.571428571429 | NELFE NELFA NELFCD NELFB | negative regulation of DNA-templated transcription, elongation |
| REAC:R-HSA-167172 | 2.87653190932e-06 | 0.571428571429 | NELFE NELFA NELFCD NELFB | Transcription of the HIV genome |
| REAC:R-HSA-674695 | 5.2974479806e-06 | 0.571428571429 | NELFE NELFA NELFCD NELFB | RNA Polymerase II Pre-transcription Events |
| REAC:R-HSA-162599 | 3.97128087888e-05 | 0.571428571429 | NELFE NELFA NELFCD NELFB | Late Phase of HIV Life Cycle |
| REAC:R-HSA-162587 | 5.66464039369e-05 | 0.571428571429 | NELFE NELFA NELFCD NELFB | HIV Life Cycle |
| GO:0008023 | 0.000163106388622 | 0.571428571429 | NELFE NELFA NELFCD NELFB | transcription elongation factor complex |
| REAC:R-HSA-162906 | 0.000333081909557 | 0.571428571429 | NELFE NELFA NELFCD NELFB | HIV Infection |
| GO:0034243 | 0.00129775343676 | 0.571428571429 | NELFE NELFA NELFCD NELFB | regulation of transcription elongation by RNA polymerase II |
| REAC:R-HSA-3700989 | 0.0018042735624 | 0.571428571429 | NELFE NELFA NELFCD NELFB | Transcriptional Regulation by TP53 |
| GO:0032784 | 0.00288826074793 | 0.571428571429 | NELFE NELFA NELFCD NELFB | regulation of DNA-templated transcription elongation |
| GO:0006368 | 0.00341296393133 | 0.571428571429 | NELFE NELFA NELFCD NELFB | transcription elongation by RNA polymerase II |
| GO:0006354 | 0.00647362376985 | 0.571428571429 | NELFE NELFA NELFCD NELFB | DNA-templated transcription elongation |
| REAC:R-HSA-9824446 | 0.0320441838438 | 0.571428571429 | NELFE NELFA NELFCD NELFB | Viral Infection Pathways |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NELFE | NELFB | 1.0 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction | |
| NELFB | NELFA | 1.0 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 | |
| NELFCD | NELFE | 1.0 | 0.56 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction |
| NELFE | NELFA | 1.0 | 0.336 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| NELFCD | NELFA | 1.0 | 0.682 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| NELFCD | NELFB | 1.0 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction | |
| NELFE | IGHMBP2 | 1.0 | 0.05 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| IGHMBP2 | NELFA | 0.999 | 0.124 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NELFCD | IGHMBP2 | 0.988 | 0.16 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| NELFCD | TMEM141 | 0.984 | 0.046 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| NELFCD | XYLT1 | 0.979 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| XYLT1 | IGHMBP2 | 0.977 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| XYLT1 | NELFB | 0.977 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| IGHMBP2 | NELFB | 0.966 | bioplex_WMM bioplex3_WMM WMM_only | |
| XYLT1 | NELFA | 0.955 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| NELFE | XYLT1 | 0.934 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| TMEM141 | NELFB | 0.25 | bioplex3_WMM WMM_only | |
| TMEM141 | IGHMBP2 | 0.25 | 0.128 | bioplex3_WMM WMM_only |
| TMEM141 | NELFA | 0.25 | 0.018 | bioplex3_WMM WMM_only |
| NELFE | TMEM141 | 0.093 | 0.036 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| NELFCD | huMAP3_01088.1 huMAP3_05354.1 huMAP3_09446.1 |
| NELFE | huMAP3_01088.1 huMAP3_05354.1 huMAP3_09446.1 |
| XYLT1 | huMAP3_01088.1 huMAP3_05354.1 huMAP3_09446.1 |
| TMEM141 | huMAP3_01088.1 huMAP3_05354.1 huMAP3_09446.1 |
| IGHMBP2 | huMAP3_01088.1 huMAP3_05354.1 huMAP3_09446.1 |
| NELFB | huMAP3_01088.1 huMAP3_05354.1 huMAP3_09446.1 |
| NELFA | huMAP3_01088.1 huMAP3_03668.1 huMAP3_05268.1 huMAP3_09446.1 |