hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_01132.1
Complex Portal: CPX-19418
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CAB39L | Calcium-binding protein 39-like (Antigen MLAA-34) (MO25beta) (Mo25-like protein) | 3 | UniProt NCBI |
| STK11 | Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19) | 5 | UniProt NCBI |
| STRADB | STE20-related kinase adapter protein beta (STRAD beta) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (CALS-21) (ILP-interacting protein) (Pseudokinase ALS2CR2) | 5 | UniProt NCBI |
| CAB39 | Calcium-binding protein 39 (MO25alpha) (Protein Mo25) | 5 | UniProt NCBI |
| STRADA | STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) (Serologically defined breast cancer antigen NY-BR-96) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-380972 | 3.47180661729e-12 | 1.0 | STRADA CAB39L STK11 CAB39 STRADB | Energy dependent regulation of mTOR by LKB1-AMPK |
| REAC:R-HSA-165159 | 2.19086769853e-11 | 1.0 | STRADA CAB39L STK11 CAB39 STRADB | MTOR signalling |
| KEGG:04152 | 1.22708457363e-09 | 1.0 | STRADA CAB39L STK11 CAB39 STRADB | AMPK signaling pathway |
| CORUM:6053 | 2.80233355908e-09 | 0.6 | CAB39 STK11 STRADA | LKB1-STRAD-MO25 complex |
| KEGG:04150 | 4.83168116998e-09 | 1.0 | STRADA CAB39L STK11 CAB39 STRADB | mTOR signaling pathway |
| WP:WP1403 | 8.59831865535e-08 | 0.8 | STRADA CAB39 STK11 STRADB | AMP activated protein kinase signaling |
| GO:0030295 | 3.95736387655e-07 | 1.0 | STRADA CAB39L STK11 CAB39 STRADB | protein kinase activator activity |
| GO:0019209 | 4.9426018149e-07 | 1.0 | STRADA CAB39L STK11 CAB39 STRADB | kinase activator activity |
| GO:1902554 | 2.19907620065e-06 | 1.0 | STRADA CAB39L STK11 CAB39 STRADB | serine/threonine protein kinase complex |
| GO:1902911 | 4.18080029939e-06 | 1.0 | STRADA CAB39L STK11 CAB39 STRADB | protein kinase complex |
| GO:0019887 | 1.12938476025e-05 | 1.0 | STRADA CAB39L STK11 CAB39 STRADB | protein kinase regulator activity |
| GO:0043539 | 1.78207144985e-05 | 0.8 | STRADA CAB39L STRADB CAB39 | protein serine/threonine kinase activator activity |
| GO:0019207 | 2.46149880859e-05 | 1.0 | STRADA CAB39L STK11 CAB39 STRADB | kinase regulator activity |
| WP:WP3932 | 2.50852598222e-05 | 0.8 | STRADA CAB39L STK11 CAB39 | Focal adhesion PI3K Akt mTOR signaling pathway |
| WP:WP3595 | 8.81804848193e-05 | 0.4 | STK11 STRADB | mir 124 predicted interactions with cell cycle and differentiation |
| GO:0061695 | 0.000115876930584 | 1.0 | STRADA CAB39L STK11 CAB39 STRADB | transferase complex, transferring phosphorus-containing groups |
| GO:0008047 | 0.000730693384304 | 1.0 | STRADA CAB39L STK11 CAB39 STRADB | enzyme activator activity |
| GO:0045860 | 0.00760417677557 | 0.8 | STRADA CAB39 STK11 STRADB | positive regulation of protein kinase activity |
| REAC:R-HSA-162582 | 0.00823431736973 | 1.0 | STRADA CAB39L STK11 CAB39 STRADB | Signal Transduction |
| GO:0033674 | 0.0106397767226 | 0.8 | STRADA CAB39 STK11 STRADB | positive regulation of kinase activity |
| GO:0140677 | 0.012079972254 | 1.0 | STRADA CAB39L STK11 CAB39 STRADB | molecular function activator activity |
| GO:1990234 | 0.0209786718727 | 1.0 | STRADA CAB39L STK11 CAB39 STRADB | transferase complex |
| GO:0051347 | 0.0324785571005 | 0.8 | STRADA CAB39 STK11 STRADB | positive regulation of transferase activity |
| GO:0032147 | 0.0379355065545 | 0.6 | STRADA STK11 STRADB | activation of protein kinase activity |
| GO:0030234 | 0.046568246072 | 1.0 | STRADA CAB39L STK11 CAB39 STRADB | enzyme regulator activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| STRADB | CAB39 | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STK11 | STRADB | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| STK11 | CAB39 | 0.999 | 0.104666666667 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STK11 | STRADA | 0.999 | 0.22 |
mutually_exclusive (Q9H9S4)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CAB39L | CAB39 | 0.999 | 0.252 |
mutually_exclusive (Q7RTN6)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CAB39 | STRADA | 0.996 | 0.08 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| CAB39L | STRADA | 0.99 | 0.08 |
mutually_exclusive (Q15831)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| STK11 | CAB39L | 0.965 | 0.106 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| STRADB | STRADA | 0.842 |
mutually_exclusive (Q9Y376)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| CAB39L | STRADB | 0.415 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| CAB39L | huMAP3_01132.1 |
| STK11 | huMAP3_00133.1 huMAP3_01132.1 huMAP3_01890.1 huMAP3_09784.1 huMAP3_10591.1 huMAP3_13837.1 huMAP3_14477.1 |
| STRADB | huMAP3_01132.1 huMAP3_01359.1 huMAP3_01890.1 huMAP3_14419.1 |
| CAB39 | huMAP3_01132.1 huMAP3_01890.1 huMAP3_01936.1 huMAP3_02705.1 huMAP3_10138.1 huMAP3_11938.1 |
| STRADA | huMAP3_01132.1 huMAP3_01890.1 |