hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_01143.1
Complex Portal: CPX-10692
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ALDOC | Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Brain-type aldolase) | 5 | UniProt NCBI |
| ALDOA | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | 5 | UniProt NCBI |
| ALDOB | Fructose-bisphosphate aldolase B (EC 4.1.2.13) (Liver-type aldolase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0004332 | 9.61200410764e-08 | 1.0 | ALDOA ALDOC ALDOB | fructose-bisphosphate aldolase activity |
| KEGG:00030 | 1.5279952182e-07 | 1.0 | ALDOA ALDOC ALDOB | Pentose phosphate pathway |
| KEGG:00051 | 3.12599090109e-07 | 1.0 | ALDOA ALDOC ALDOB | Fructose and mannose metabolism |
| WP:WP534 | 8.89885541579e-07 | 1.0 | ALDOA ALDOC ALDOB | Glycolysis and gluconeogenesis |
| REAC:R-HSA-70263 | 1.36481126286e-06 | 1.0 | ALDOA ALDOC ALDOB | Gluconeogenesis |
| GO:0016832 | 1.92240082153e-06 | 1.0 | ALDOA ALDOC ALDOB | aldehyde-lyase activity |
| KEGG:00010 | 1.97568475734e-06 | 1.0 | ALDOA ALDOC ALDOB | Glycolysis / Gluconeogenesis |
| KEGG:01230 | 2.50251661292e-06 | 1.0 | ALDOA ALDOC ALDOB | Biosynthesis of amino acids |
| WP:WP4018 | 5.23427884975e-06 | 1.0 | ALDOA ALDOC ALDOB | Clear cell renal cell carcinoma pathways |
| WP:WP5355 | 7.93300403529e-06 | 1.0 | ALDOA ALDOC ALDOB | Metabolic Epileptic Disorders |
| GO:0030388 | 8.07408345042e-06 | 1.0 | ALDOA ALDOC ALDOB | fructose 1,6-bisphosphate metabolic process |
| GO:0006000 | 8.07408345042e-06 | 1.0 | ALDOA ALDOC ALDOB | fructose metabolic process |
| KEGG:04066 | 8.19365887109e-06 | 1.0 | ALDOA ALDOC ALDOB | HIF-1 signaling pathway |
| KEGG:01200 | 9.51295867401e-06 | 1.0 | ALDOA ALDOC ALDOB | Carbon metabolism |
| HP:0012545 | 1.26540735158e-05 | 0.666666666667 | ALDOA ALDOB | Reduced circulating aldolase concentration |
| REAC:R-HSA-70171 | 2.03811815253e-05 | 1.0 | ALDOA ALDOC ALDOB | Glycolysis |
| REAC:R-HSA-70326 | 3.68984307198e-05 | 1.0 | ALDOA ALDOC ALDOB | Glucose metabolism |
| GO:0016830 | 0.000629105668845 | 1.0 | ALDOA ALDOC ALDOB | carbon-carbon lyase activity |
| REAC:R-HSA-71387 | 0.0012894643491 | 1.0 | ALDOA ALDOC ALDOB | Metabolism of carbohydrates |
| HP:0012400 | 0.00348901893966 | 0.666666666667 | ALDOA ALDOB | Abnormal circulating aldolase concentration |
| GO:0046032 | 0.00419852339422 | 1.0 | ALDOA ALDOC ALDOB | ADP catabolic process |
| GO:0006096 | 0.00419852339422 | 1.0 | ALDOA ALDOC ALDOB | glycolytic process |
| GO:0046031 | 0.00439845307966 | 1.0 | ALDOA ALDOC ALDOB | ADP metabolic process |
| GO:0009181 | 0.00460463056777 | 1.0 | ALDOA ALDOC ALDOB | purine ribonucleoside diphosphate catabolic process |
| GO:0009137 | 0.00460463056777 | 1.0 | ALDOA ALDOC ALDOB | purine nucleoside diphosphate catabolic process |
| GO:0009179 | 0.00481715197859 | 1.0 | ALDOA ALDOC ALDOB | purine ribonucleoside diphosphate metabolic process |
| GO:0019364 | 0.00481715197859 | 1.0 | ALDOA ALDOC ALDOB | pyridine nucleotide catabolic process |
| GO:0009135 | 0.00503611343216 | 1.0 | ALDOA ALDOC ALDOB | purine nucleoside diphosphate metabolic process |
| GO:0009191 | 0.00526161104852 | 1.0 | ALDOA ALDOC ALDOB | ribonucleoside diphosphate catabolic process |
| GO:0072526 | 0.00549374094772 | 1.0 | ALDOA ALDOC ALDOB | pyridine-containing compound catabolic process |
| GO:0009134 | 0.0057325992498 | 1.0 | ALDOA ALDOC ALDOB | nucleoside diphosphate catabolic process |
| GO:0009185 | 0.00675723888767 | 1.0 | ALDOA ALDOC ALDOB | ribonucleoside diphosphate metabolic process |
| GO:0009132 | 0.00789722257484 | 1.0 | ALDOA ALDOC ALDOB | nucleoside diphosphate metabolic process |
| GO:0006090 | 0.0105478288276 | 1.0 | ALDOA ALDOC ALDOB | pyruvate metabolic process |
| GO:0009154 | 0.0120707547584 | 1.0 | ALDOA ALDOC ALDOB | purine ribonucleotide catabolic process |
| GO:0009261 | 0.0128843147861 | 1.0 | ALDOA ALDOC ALDOB | ribonucleotide catabolic process |
| GO:0006195 | 0.0146194737676 | 1.0 | ALDOA ALDOC ALDOB | purine nucleotide catabolic process |
| GO:0072523 | 0.0165038110528 | 1.0 | ALDOA ALDOC ALDOB | purine-containing compound catabolic process |
| GO:0016052 | 0.0175038439602 | 1.0 | ALDOA ALDOC ALDOB | carbohydrate catabolic process |
| KEGG:01100 | 0.0189521995452 | 1.0 | ALDOA ALDOC ALDOB | Metabolic pathways |
| GO:0070061 | 0.0210651876021 | 0.666666666667 | ALDOA ALDOB | fructose binding |
| GO:0009166 | 0.023732518742 | 1.0 | ALDOA ALDOC ALDOB | nucleotide catabolic process |
| GO:0046496 | 0.0263194935275 | 1.0 | ALDOA ALDOC ALDOB | nicotinamide nucleotide metabolic process |
| GO:0019362 | 0.0263194935275 | 1.0 | ALDOA ALDOC ALDOB | pyridine nucleotide metabolic process |
| GO:1901292 | 0.0269943523359 | 1.0 | ALDOA ALDOC ALDOB | nucleoside phosphate catabolic process |
| GO:0072524 | 0.0290879429506 | 1.0 | ALDOA ALDOC ALDOB | pyridine-containing compound metabolic process |
| GO:0016829 | 0.0312870733704 | 1.0 | ALDOA ALDOC ALDOB | lyase activity |
| WP:WP690 | 0.0331010360575 | 0.333333333333 | ALDOB | Polyol pathway |
| GO:0019318 | 0.0335943388364 | 1.0 | ALDOA ALDOC ALDOB | hexose metabolic process |
| HPA:0090951 | 0.0377732318968 | 0.666666666667 | ALDOA ALDOC | cerebellum; Purkinje cells - dendrites[>=Low] |
| GO:0005996 | 0.043021407985 | 1.0 | ALDOA ALDOC ALDOB | monosaccharide metabolic process |
| REAC:R-HSA-5657560 | 0.0498224659464 | 0.333333333333 | ALDOB | Hereditary fructose intolerance |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ALDOC | ALDOA | 0.999 | 0.78 |
mutually_exclusive (P05062)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 fraction treiber_WMM |
| ALDOA | ALDOB | 0.994 | 0.298 |
mutually_exclusive (P09972)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ALDOC | ALDOB | 0.987 | 0.174 |
mutually_exclusive (P04075)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| ALDOC | huMAP3_01143.1 huMAP3_04317.1 huMAP3_12505.1 |
| ALDOA | huMAP3_01143.1 huMAP3_04317.1 huMAP3_12505.1 |
| ALDOB | huMAP3_01143.1 huMAP3_04317.1 huMAP3_06225.1 huMAP3_12505.1 |