hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01149.1
Complex Portal: CPX-22426
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| H2BC13 | Histone H2B type 1-L (Histone H2B.c) (H2B/c) | 5 | UniProt NCBI |
| H2BC26 | Histone H2B type 3-B (H2B type 12) (H2B-clustered histone 26) (H2B.U histone 1) | 5 | UniProt NCBI |
| CFDP1 | Craniofacial development protein 1 (Bucentaur) | 4 | UniProt NCBI |
| RBP1 | Retinol-binding protein 1 (Cellular retinol-binding protein) (CRBP) (Cellular retinol-binding protein I) (CRBP-I) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HPA:0500703 | 0.00107468477047 | 0.75 | CFDP1 H2BC13 H2BC26 | soft tissue 1; peripheral nerve[High] |
| HPA:0050013 | 0.00219592741573 | 0.75 | CFDP1 H2BC13 H2BC26 | breast; adipocytes[High] |
| HPA:0010013 | 0.00715164856367 | 0.75 | CFDP1 H2BC13 H2BC26 | adipose tissue; adipocytes[High] |
| REAC:R-HSA-171306 | 0.0079693038543 | 0.5 | H2BC13 H2BC26 | Packaging Of Telomere Ends |
| REAC:R-HSA-110330 | 0.00922347264132 | 0.5 | H2BC13 H2BC26 | Recognition and association of DNA glycosylase with site containing an affected purine |
| REAC:R-HSA-73927 | 0.00922347264132 | 0.5 | H2BC13 H2BC26 | Depurination |
| REAC:R-HSA-110331 | 0.00922347264132 | 0.5 | H2BC13 H2BC26 | Cleavage of the damaged purine |
| HPA:0510653 | 0.0106512929451 | 0.75 | CFDP1 H2BC13 H2BC26 | soft tissue 2; fibroblasts[High] |
| REAC:R-HSA-110328 | 0.0110375739361 | 0.5 | H2BC13 H2BC26 | Recognition and association of DNA glycosylase with site containing an affected pyrimidine |
| REAC:R-HSA-73928 | 0.0110375739361 | 0.5 | H2BC13 H2BC26 | Depyrimidination |
| REAC:R-HSA-110329 | 0.0110375739361 | 0.5 | H2BC13 H2BC26 | Cleavage of the damaged pyrimidine |
| HPA:0570733 | 0.0113500251897 | 1.0 | CFDP1 H2BC13 RBP1 H2BC26 | testis; Leydig cells[High] |
| REAC:R-HSA-73929 | 0.0115164156767 | 0.5 | H2BC13 H2BC26 | Base-Excision Repair, AP Site Formation |
| REAC:R-HSA-73728 | 0.0130136556072 | 0.5 | H2BC13 H2BC26 | RNA Polymerase I Promoter Opening |
| REAC:R-HSA-5334118 | 0.0135329645116 | 0.5 | H2BC13 H2BC26 | DNA methylation |
| KEGG:05322 | 0.014352694406 | 0.5 | H2BC13 H2BC26 | Systemic lupus erythematosus |
| REAC:R-HSA-5625886 | 0.0146019089592 | 0.5 | H2BC13 H2BC26 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
| REAC:R-HSA-9670095 | 0.0151515389193 | 0.5 | H2BC13 H2BC26 | Inhibition of DNA recombination at telomere |
| REAC:R-HSA-427359 | 0.0157112703152 | 0.5 | H2BC13 H2BC26 | SIRT1 negatively regulates rRNA expression |
| REAC:R-HSA-68616 | 0.0162811003561 | 0.5 | H2BC13 H2BC26 | Assembly of the ORC complex at the origin of replication |
| REAC:R-HSA-2299718 | 0.0180511544442 | 0.5 | H2BC13 H2BC26 | Condensation of Prophase Chromosomes |
| REAC:R-HSA-212300 | 0.0186613511621 | 0.5 | H2BC13 H2BC26 | PRC2 methylates histones and DNA |
| REAC:R-HSA-9710421 | 0.0186613511621 | 0.5 | H2BC13 H2BC26 | Defective pyroptosis |
| REAC:R-HSA-5693571 | 0.0186613511621 | 0.5 | H2BC13 H2BC26 | Nonhomologous End-Joining (NHEJ) |
| REAC:R-HSA-774815 | 0.0186613511621 | 0.5 | H2BC13 H2BC26 | Nucleosome assembly |
| REAC:R-HSA-606279 | 0.0186613511621 | 0.5 | H2BC13 H2BC26 | Deposition of new CENPA-containing nucleosomes at the centromere |
| REAC:R-HSA-1221632 | 0.019281632575 | 0.5 | H2BC13 H2BC26 | Meiotic synapsis |
| REAC:R-HSA-427389 | 0.0205524383293 | 0.5 | H2BC13 H2BC26 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression |
| HPA:0340462 | 0.0206302734533 | 1.0 | CFDP1 H2BC13 RBP1 H2BC26 | ovary; ovarian stroma cells[>=Medium] |
| HPA:0460653 | 0.0215291945172 | 0.75 | CFDP1 H2BC13 H2BC26 | skin 1; fibroblasts[High] |
| REAC:R-HSA-2559586 | 0.022534212454 | 0.5 | H2BC13 H2BC26 | DNA Damage/Telomere Stress Induced Senescence |
| REAC:R-HSA-9616222 | 0.0253175164514 | 0.5 | H2BC13 H2BC26 | Transcriptional regulation of granulopoiesis |
| REAC:R-HSA-5693565 | 0.0253175164514 | 0.5 | H2BC13 H2BC26 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| HPA:0510112 | 0.0254250004786 | 0.75 | CFDP1 H2BC13 H2BC26 | soft tissue 2; chondrocytes[>=Medium] |
| REAC:R-HSA-5693606 | 0.0260384914588 | 0.5 | H2BC13 H2BC26 | DNA Double Strand Break Response |
| REAC:R-HSA-912446 | 0.0260384914588 | 0.5 | H2BC13 H2BC26 | Meiotic recombination |
| KEGG:04613 | 0.0272860662684 | 0.5 | H2BC13 H2BC26 | Neutrophil extracellular trap formation |
| KEGG:05034 | 0.0272860662684 | 0.5 | H2BC13 H2BC26 | Alcoholism |
| HPA:0160252 | 0.0287234436749 | 1.0 | CFDP1 H2BC13 RBP1 H2BC26 | endometrium 1; cells in endometrial stroma[>=Medium] |
| REAC:R-HSA-1912408 | 0.0290229039331 | 0.5 | H2BC13 H2BC26 | Pre-NOTCH Transcription and Translation |
| REAC:R-HSA-73884 | 0.0290229039331 | 0.5 | H2BC13 H2BC26 | Base Excision Repair |
| REAC:R-HSA-201722 | 0.0297941212351 | 0.5 | H2BC13 H2BC26 | Formation of the beta-catenin:TCF transactivating complex |
| REAC:R-HSA-5250924 | 0.0305753786405 | 0.5 | H2BC13 H2BC26 | B-WICH complex positively regulates rRNA expression |
| REAC:R-HSA-73772 | 0.0313666733646 | 0.5 | H2BC13 H2BC26 | RNA Polymerase I Promoter Escape |
| REAC:R-HSA-8936459 | 0.0321680026233 | 0.5 | H2BC13 H2BC26 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| REAC:R-HSA-3214815 | 0.0321680026233 | 0.5 | H2BC13 H2BC26 | HDACs deacetylate histones |
| REAC:R-HSA-5625740 | 0.0329793636325 | 0.5 | H2BC13 H2BC26 | RHO GTPases activate PKNs |
| REAC:R-HSA-69473 | 0.0380580405855 | 0.5 | H2BC13 H2BC26 | G2/M DNA damage checkpoint |
| REAC:R-HSA-5693607 | 0.0407325822829 | 0.5 | H2BC13 H2BC26 | Processing of DNA double-strand break ends |
| REAC:R-HSA-9645723 | 0.041644107744 | 0.5 | H2BC13 H2BC26 | Diseases of programmed cell death |
| REAC:R-HSA-5578749 | 0.041644107744 | 0.5 | H2BC13 H2BC26 | Transcriptional regulation by small RNAs |
| KEGG:05203 | 0.0424327978034 | 0.5 | H2BC13 H2BC26 | Viral carcinogenesis |
| REAC:R-HSA-1912422 | 0.0425656343513 | 0.5 | H2BC13 H2BC26 | Pre-NOTCH Expression and Processing |
| REAC:R-HSA-5250913 | 0.0434971593242 | 0.5 | H2BC13 H2BC26 | Positive epigenetic regulation of rRNA expression |
| REAC:R-HSA-427413 | 0.0444386798825 | 0.5 | H2BC13 H2BC26 | NoRC negatively regulates rRNA expression |
| REAC:R-HSA-977225 | 0.0453901932463 | 0.5 | H2BC13 H2BC26 | Amyloid fiber formation |
| REAC:R-HSA-2559582 | 0.0473231872721 | 0.5 | H2BC13 H2BC26 | Senescence-Associated Secretory Phenotype (SASP) |
| REAC:R-HSA-5250941 | 0.0473231872721 | 0.5 | H2BC13 H2BC26 | Negative epigenetic regulation of rRNA expression |
| REAC:R-HSA-73854 | 0.0483046623758 | 0.5 | H2BC13 H2BC26 | RNA Polymerase I Promoter Clearance |
| REAC:R-HSA-9610379 | 0.0492961191682 | 0.5 | H2BC13 H2BC26 | HCMV Late Events |
| REAC:R-HSA-1500620 | 0.0492961191682 | 0.5 | H2BC13 H2BC26 | Meiosis |
| REAC:R-HSA-73864 | 0.0492961191682 | 0.5 | H2BC13 H2BC26 | RNA Polymerase I Transcription |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| H2BC26 | CFDP1 | 0.995 | 0.214820512821 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| H2BC13 | H2BC26 | 0.971 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| H2BC26 | RBP1 | 0.951 | 0.092 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| H2BC13 | CFDP1 | 0.297 | bioplex_WMM bioplex3_WMM WMM_only | ||
| RBP1 | CFDP1 | 0.076 | 0.024 | bioplex3_WMM WMM_only | |
| H2BC13 | RBP1 | 0.076 | bioplex3_WMM WMM_only |
Related Complexes