hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01169.1
Complex Portal: CPX-11276
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NHLH2 | Helix-loop-helix protein 2 (HEN-2) (Class A basic helix-loop-helix protein 34) (bHLHa34) (Nescient helix loop helix 2) (NSCL-2) | 5 | UniProt NCBI |
| ID1 | DNA-binding protein inhibitor ID-1 (Class B basic helix-loop-helix protein 24) (bHLHb24) (Inhibitor of DNA binding 1) (Inhibitor of differentiation 1) | 5 | UniProt NCBI |
| MYF6 | Myogenic factor 6 (Myf-6) (Class C basic helix-loop-helix protein 4) (bHLHc4) (Muscle-specific regulatory factor 4) | 5 | UniProt NCBI |
| FERD3L | Fer3-like protein (Basic helix-loop-helix protein N-twist) (Class A basic helix-loop-helix protein 31) (bHLHa31) (Nephew of atonal 3) (Neuronal twist) | 5 | UniProt NCBI |
| TCF12 | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | 5 | UniProt NCBI |
| TWIST2 | Twist-related protein 2 (Class A basic helix-loop-helix protein 39) (bHLHa39) (Dermis-expressed protein 1) (Dermo-1) | 5 | UniProt NCBI |
| ASCL4 | Achaete-scute homolog 4 (ASH-4) (hASH4) (Achaete-scute-like protein 4) (Class A basic helix-loop-helix protein 44) (bHLHa44) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-525793 | 0.0104655132242 | 0.285714285714 | TCF12 MYF6 | Myogenesis |
| GO:0000981 | 0.0149492583488 | 0.857142857143 | NHLH2 TCF12 TWIST2 MYF6 ASCL4 FERD3L | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0006357 | 0.0154035672085 | 1.0 | NHLH2 TCF12 ID1 TWIST2 MYF6 ASCL4 FERD3L | regulation of transcription by RNA polymerase II |
| GO:0000977 | 0.0176866511184 | 0.857142857143 | NHLH2 TCF12 TWIST2 MYF6 ASCL4 FERD3L | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| REAC:R-HSA-9031628 | 0.0187732752758 | 0.285714285714 | TCF12 ID1 | NGF-stimulated transcription |
| GO:0003700 | 0.0216467787346 | 0.857142857143 | NHLH2 TCF12 TWIST2 MYF6 ASCL4 FERD3L | DNA-binding transcription factor activity |
| GO:0006366 | 0.0223743566348 | 1.0 | NHLH2 TCF12 ID1 TWIST2 MYF6 ASCL4 FERD3L | transcription by RNA polymerase II |
| GO:0000976 | 0.0293914854629 | 0.857142857143 | NHLH2 TCF12 TWIST2 MYF6 ASCL4 FERD3L | transcription cis-regulatory region binding |
| GO:0001067 | 0.0295707017041 | 0.857142857143 | NHLH2 TCF12 TWIST2 MYF6 ASCL4 FERD3L | transcription regulatory region nucleic acid binding |
| GO:1990837 | 0.038854695694 | 0.857142857143 | NHLH2 TCF12 TWIST2 MYF6 ASCL4 FERD3L | sequence-specific double-stranded DNA binding |
| CORUM:2937 | 0.0499958217778 | 0.142857142857 | TCF12 | PTF1-bHLH complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NHLH2 | ID1 | 0.997 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ID1 | ASCL4 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| FERD3L | TCF12 | 0.996 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MYF6 | TCF12 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| NHLH2 | TCF12 | 0.994 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ID1 | TCF12 | 0.988 | hein_WMM bioplex_WMM bioplex3_WMM hein () | ||
| TCF12 | ASCL4 | 0.984 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TCF12 | TWIST2 | 0.981 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ID1 | TWIST2 | 0.363 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes