hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01176.1
Complex Portal: CPX-2234
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GMPPA | Mannose-1-phosphate guanyltransferase alpha (GDP-mannose pyrophosphorylase A) (GMPP-alpha) (GTP-mannose-1-phosphate guanylyltransferase alpha) | 5 | UniProt NCBI |
| GMPPB | Mannose-1-phosphate guanyltransferase beta (EC 2.7.7.13) (GDP-mannose pyrophosphorylase B) (GTP-mannose-1-phosphate guanylyltransferase beta) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-446205 | 1.70876175213e-05 | 1.0 | GMPPA GMPPB | Synthesis of GDP-mannose |
| KEGG:00051 | 9.12015985996e-05 | 1.0 | GMPPA GMPPB | Fructose and mannose metabolism |
| KEGG:01250 | 9.67289682117e-05 | 1.0 | GMPPA GMPPB | Biosynthesis of nucleotide sugars |
| KEGG:00520 | 0.000160943997529 | 1.0 | GMPPA GMPPB | Amino sugar and nucleotide sugar metabolism |
| WP:WP5153 | 0.000542687198278 | 1.0 | GMPPA GMPPB | N glycan biosynthesis |
| KEGG:01240 | 0.00144865854745 | 1.0 | GMPPA GMPPB | Biosynthesis of cofactors |
| REAC:R-HSA-446219 | 0.00282458317627 | 1.0 | GMPPA GMPPB | Synthesis of substrates in N-glycan biosythesis |
| REAC:R-HSA-446193 | 0.00449062588459 | 1.0 | GMPPA GMPPB | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| HP:0001430 | 0.00526298619656 | 1.0 | GMPPA GMPPB | Abnormal calf musculature morphology |
| HP:0001437 | 0.0127849554294 | 1.0 | GMPPA GMPPB | Abnormality of the musculature of the lower limbs |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GMPPA | GMPPB | 1.0 | 0.838 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 fraction |
Related Complexes