hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_01217.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SRP54 | Signal recognition particle subunit SRP54 (EC 3.6.5.4) (Signal recognition particle 54 kDa protein) | 5 | UniProt NCBI |
| SRP19 | Signal recognition particle 19 kDa protein (SRP19) | 5 | UniProt NCBI |
| SRP9 | Signal recognition particle 9 kDa protein (SRP9) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03060 | 2.12090960201e-07 | 1.0 | SRP19 SRP54 SRP9 | Protein export |
| GO:0005786 | 1.92240082153e-06 | 1.0 | SRP19 SRP54 SRP9 | signal recognition particle, endoplasmic reticulum targeting |
| GO:0048500 | 1.92240082153e-06 | 1.0 | SRP19 SRP54 SRP9 | signal recognition particle |
| GO:0006614 | 1.58598067776e-05 | 1.0 | SRP19 SRP54 SRP9 | SRP-dependent cotranslational protein targeting to membrane |
| GO:0006613 | 7.84339535184e-05 | 1.0 | SRP19 SRP54 SRP9 | cotranslational protein targeting to membrane |
| REAC:R-HSA-1799339 | 0.000100702074103 | 1.0 | SRP19 SRP54 SRP9 | SRP-dependent cotranslational protein targeting to membrane |
| GO:0045047 | 0.000314889254566 | 1.0 | SRP19 SRP54 SRP9 | protein targeting to ER |
| HP:0025452 | 0.000354217072454 | 0.666666666667 | SRP19 SRP54 | Pyoderma gangrenosum |
| GO:0072599 | 0.000432059584639 | 1.0 | SRP19 SRP54 SRP9 | establishment of protein localization to endoplasmic reticulum |
| HP:0012311 | 0.000834787835662 | 0.666666666667 | SRP19 SRP54 | Monocytosis |
| HP:0012310 | 0.00115089028102 | 0.666666666667 | SRP19 SRP54 | Abnormal monocyte count |
| HP:0012144 | 0.00115089028102 | 0.666666666667 | SRP19 SRP54 | Abnormal monocyte morphology |
| HP:0025439 | 0.00151751896202 | 0.666666666667 | SRP19 SRP54 | Pharyngitis |
| REAC:R-HSA-72766 | 0.00183838257359 | 1.0 | SRP19 SRP54 SRP9 | Translation |
| HP:0410018 | 0.00216216836724 | 0.666666666667 | SRP19 SRP54 | Recurrent ear infections |
| GO:0070972 | 0.00266444753864 | 1.0 | SRP19 SRP54 SRP9 | protein localization to endoplasmic reticulum |
| HP:0001915 | 0.00379223870168 | 0.666666666667 | SRP19 SRP54 | Aplastic anemia |
| HP:0000230 | 0.0047775661087 | 0.666666666667 | SRP19 SRP54 | Gingivitis |
| HP:0004798 | 0.00587635932745 | 0.666666666667 | SRP19 SRP54 | Recurrent infection of the gastrointestinal tract |
| HP:0000704 | 0.00667190161012 | 0.666666666667 | SRP19 SRP54 | Periodontitis |
| HP:0011107 | 0.00667190161012 | 0.666666666667 | SRP19 SRP54 | Recurrent aphthous stomatitis |
| HP:0006721 | 0.0075178385046 | 0.666666666667 | SRP19 SRP54 | Acute lymphoblastic leukemia |
| HP:0003453 | 0.00841415615575 | 0.666666666667 | SRP19 SRP54 | Antineutrophil antibody positivity |
| GO:0006617 | 0.00842684400117 | 0.666666666667 | SRP19 SRP54 | SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition |
| HP:0100658 | 0.00936084070842 | 0.666666666667 | SRP19 SRP54 | Cellulitis |
| GO:0006612 | 0.0105478288276 | 1.0 | SRP19 SRP54 SRP9 | protein targeting to membrane |
| HP:0001880 | 0.0108752751697 | 0.666666666667 | SRP19 SRP54 | Eosinophilia |
| HP:0004429 | 0.0130706759587 | 0.666666666667 | SRP19 SRP54 | Recurrent viral infections |
| HP:0006480 | 0.0136509708315 | 0.666666666667 | SRP19 SRP54 | Premature loss of teeth |
| HP:0005425 | 0.0142438401108 | 0.666666666667 | SRP19 SRP54 | Recurrent sinopulmonary infections |
| HP:0020064 | 0.0154672949612 | 0.666666666667 | SRP19 SRP54 | Abnormal eosinophil count |
| HP:0000155 | 0.0160978770685 | 0.666666666667 | SRP19 SRP54 | Oral ulcer |
| HP:0010280 | 0.0180650213362 | 0.666666666667 | SRP19 SRP54 | Stomatitis |
| HP:0001879 | 0.0187458629677 | 0.666666666667 | SRP19 SRP54 | Abnormal eosinophil morphology |
| GO:0008312 | 0.0210651876021 | 0.666666666667 | SRP19 SRP54 | 7S RNA binding |
| HP:0004808 | 0.0295957156854 | 0.666666666667 | SRP19 SRP54 | Acute myeloid leukemia |
| HP:0031446 | 0.0322405218297 | 0.666666666667 | SRP19 SRP54 | Erosion of oral mucosa |
| GO:0043021 | 0.0351938724399 | 1.0 | SRP19 SRP54 SRP9 | ribonucleoprotein complex binding |
| HP:0012384 | 0.037868427304 | 0.666666666667 | SRP19 SRP54 | Rhinitis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SRP54 | SRP9 | 0.999 | 0.246 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| SRP19 | SRP9 | 0.999 | 0.158 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| SRP54 | SRP19 | 0.951 | 0.904 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction |
Related Complexes
| Genename | Complexes |
|---|---|
| SRP54 | huMAP3_01217.1 huMAP3_05187.1 huMAP3_08671.1 huMAP3_09390.1 |
| SRP19 | huMAP3_01217.1 huMAP3_07765.1 huMAP3_11495.1 |
| SRP9 | huMAP3_01217.1 huMAP3_07156.1 huMAP3_09207.1 huMAP3_11495.1 huMAP3_13500.1 |