hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01218.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RMI2 | RecQ-mediated genome instability protein 2 (hRMI2) (BLM-associated protein of 18 kDa) (BLAP18) | 5 | UniProt NCBI |
| TOP3A | DNA topoisomerase 3-alpha (EC 5.6.2.1) (DNA topoisomerase III alpha) | 5 | UniProt NCBI |
| RMI1 | RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75) | 5 | UniProt NCBI |
| CCDC69 | Coiled-coil domain-containing protein 69 | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0031422 | 1.53784171933e-06 | 0.75 | RMI1 RMI2 TOP3A | RecQ family helicase-topoisomerase III complex |
| REAC:R-HSA-9709603 | 2.8370403595e-06 | 0.75 | RMI1 RMI2 TOP3A | Impaired BRCA2 binding to PALB2 |
| REAC:R-HSA-9704331 | 3.2237438451e-06 | 0.75 | RMI1 RMI2 TOP3A | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function |
| REAC:R-HSA-9704646 | 3.2237438451e-06 | 0.75 | RMI1 RMI2 TOP3A | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function |
| REAC:R-HSA-9701192 | 3.2237438451e-06 | 0.75 | RMI1 RMI2 TOP3A | Defective homologous recombination repair (HRR) due to BRCA1 loss of function |
| REAC:R-HSA-9701193 | 3.2237438451e-06 | 0.75 | RMI1 RMI2 TOP3A | Defective homologous recombination repair (HRR) due to PALB2 loss of function |
| REAC:R-HSA-5693554 | 4.0993398561e-06 | 0.75 | RMI1 RMI2 TOP3A | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| KEGG:03460 | 6.30976562692e-06 | 0.75 | RMI1 RMI2 TOP3A | Fanconi anemia pathway |
| REAC:R-HSA-5693568 | 7.64413736449e-06 | 0.75 | RMI1 RMI2 TOP3A | Resolution of D-loop Structures through Holliday Junction Intermediates |
| GO:0071139 | 7.68841921772e-06 | 0.75 | RMI1 RMI2 TOP3A | resolution of DNA recombination intermediates |
| REAC:R-HSA-5693537 | 8.38346160394e-06 | 0.75 | RMI1 RMI2 TOP3A | Resolution of D-Loop Structures |
| REAC:R-HSA-9709570 | 8.38346160394e-06 | 0.75 | RMI1 RMI2 TOP3A | Impaired BRCA2 binding to RAD51 |
| REAC:R-HSA-5685938 | 9.16893973468e-06 | 0.75 | RMI1 RMI2 TOP3A | HDR through Single Strand Annealing (SSA) |
| REAC:R-HSA-5693616 | 1.28002609524e-05 | 0.75 | RMI1 RMI2 TOP3A | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-9701190 | 1.38374083551e-05 | 0.75 | RMI1 RMI2 TOP3A | Defective homologous recombination repair (HRR) due to BRCA2 loss of function |
| REAC:R-HSA-9675136 | 1.38374083551e-05 | 0.75 | RMI1 RMI2 TOP3A | Diseases of DNA Double-Strand Break Repair |
| REAC:R-HSA-5693579 | 1.60766305396e-05 | 0.75 | RMI1 RMI2 TOP3A | Homologous DNA Pairing and Strand Exchange |
| REAC:R-HSA-9675135 | 2.57917427086e-05 | 0.75 | RMI1 RMI2 TOP3A | Diseases of DNA repair |
| CORUM:246 | 3.07520988333e-05 | 0.5 | TOP3A RMI1 | BLM complex III |
| CORUM:2738 | 5.12488211613e-05 | 0.5 | TOP3A RMI1 | BLM complex II |
| CORUM:2222 | 5.12488211613e-05 | 0.5 | TOP3A RMI1 | BLM complex II |
| REAC:R-HSA-5685942 | 6.40033583955e-05 | 0.75 | RMI1 RMI2 TOP3A | HDR through Homologous Recombination (HRR) |
| REAC:R-HSA-69473 | 0.000148092217351 | 0.75 | RMI1 RMI2 TOP3A | G2/M DNA damage checkpoint |
| WP:WP5381 | 0.000155341404028 | 0.75 | RMI1 RMI2 TOP3A | Smith Magenis and Potocki Lupski syndrome copy number variation |
| REAC:R-HSA-6804756 | 0.000158650980172 | 0.75 | RMI1 RMI2 TOP3A | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-5693607 | 0.000164113242291 | 0.75 | RMI1 RMI2 TOP3A | Processing of DNA double-strand break ends |
| CORUM:2739 | 0.000230514481314 | 0.5 | TOP3A RMI1 | FA complex (Fanconi anemia complex) |
| CORUM:244 | 0.000281714206611 | 0.5 | TOP3A RMI1 | BRAFT complex |
| REAC:R-HSA-5693567 | 0.000422025999557 | 0.75 | RMI1 RMI2 TOP3A | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 0.000487256563506 | 0.75 | RMI1 RMI2 TOP3A | Homology Directed Repair |
| REAC:R-HSA-5633007 | 0.000799005459147 | 0.75 | RMI1 RMI2 TOP3A | Regulation of TP53 Activity |
| REAC:R-HSA-5693532 | 0.000897810107574 | 0.75 | RMI1 RMI2 TOP3A | DNA Double-Strand Break Repair |
| REAC:R-HSA-69481 | 0.000915028341188 | 0.75 | RMI1 RMI2 TOP3A | G2/M Checkpoints |
| REAC:R-HSA-69620 | 0.00495341247057 | 0.75 | RMI1 RMI2 TOP3A | Cell Cycle Checkpoints |
| REAC:R-HSA-73894 | 0.00653220236003 | 0.75 | RMI1 RMI2 TOP3A | DNA Repair |
| WP:WP4016 | 0.00742144474402 | 0.5 | TOP3A RMI1 | DNA IR damage and cellular response via ATR |
| REAC:R-HSA-3700989 | 0.00879681508035 | 0.75 | RMI1 RMI2 TOP3A | Transcriptional Regulation by TP53 |
| CORUM:2223 | 0.049938562206 | 0.25 | TOP3A | BLM-TOP3A complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TOP3A | CCDC69 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RMI2 | TOP3A | 0.995 | 0.162 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| CCDC69 | RMI1 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TOP3A | RMI1 | 0.994 | 0.346 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RMI2 | CCDC69 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RMI2 | RMI1 | 0.988 | 0.284 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| RMI2 | huMAP3_00733.1 huMAP3_01218.1 huMAP3_04213.1 huMAP3_07537.1 |
| TOP3A | huMAP3_00733.1 huMAP3_01218.1 huMAP3_04213.1 huMAP3_07537.1 |
| RMI1 | huMAP3_01218.1 huMAP3_04213.1 |
| CCDC69 | huMAP3_00733.1 huMAP3_01218.1 huMAP3_07537.1 huMAP3_13411.1 huMAP3_13908.1 |