hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01225.1
Complex Portal: CPX-17234
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| AKR1C1 | Aldo-keto reductase family 1 member C1 (EC 1.1.1.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.210) (EC 1.1.1.357) (EC 1.1.1.51) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC 1.1.1.149) (Chlordecone reductase homolog HAKRC) (Dihydrodiol dehydrogenase 1) (DD1) (High-affinity hepatic bile acid-binding protein) (HBAB) | 5 | UniProt NCBI |
| AKR1D1 | Aldo-keto reductase family 1 member D1 (EC 1.3.1.3) (3-oxo-5-beta-steroid 4-dehydrogenase) (Delta(4)-3-ketosteroid 5-beta-reductase) (Delta(4)-3-oxosteroid 5-beta-reductase) | 5 | UniProt NCBI |
| AKR1C2 | Aldo-keto reductase family 1 member C2 (EC 1.-.-.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (3-alpha-HSD3) (Chlordecone reductase homolog HAKRD) (Dihydrodiol dehydrogenase 2) (DD-2) (DD2) (Dihydrodiol dehydrogenase/bile acid-binding protein) (DD/BABP) (Type III 3-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.357) | 5 | UniProt NCBI |
| AKR1C3 | Aldo-keto reductase family 1 member C3 (EC 1.1.1.-) (EC 1.1.1.210) (EC 1.1.1.53) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239, EC 1.1.1.64) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5279 | 3.01399227923e-12 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | Mineralocorticoid biosynthesis |
| WP:WP5280 | 5.02332046538e-12 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | Glucocorticoid biosynthesis |
| REAC:R-HSA-193775 | 6.72220500234e-12 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| REAC:R-HSA-193807 | 2.0166615007e-11 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol |
| REAC:R-HSA-193368 | 9.61275315334e-11 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| GO:0047086 | 1.31563155046e-10 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | ketosteroid monooxygenase activity |
| REAC:R-HSA-192105 | 5.747485277e-10 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | Synthesis of bile acids and bile salts |
| KEGG:00140 | 2.14706370351e-09 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | Steroid hormone biosynthesis |
| REAC:R-HSA-194068 | 2.28084415729e-09 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | Bile acid and bile salt metabolism |
| GO:0004032 | 5.52565251192e-09 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | alditol:NADP+ 1-oxidoreductase activity |
| WP:WP696 | 1.95685123169e-08 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | Benzo a pyrene metabolism |
| GO:0008106 | 8.0516650888e-08 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | alcohol dehydrogenase (NADP+) activity |
| GO:0008207 | 1.5748109659e-07 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | C21-steroid hormone metabolic process |
| GO:0016709 | 2.32998347586e-07 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| GO:0004033 | 2.79598017103e-07 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | aldo-keto reductase (NADP) activity |
| WP:WP702 | 3.16537004145e-07 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | Metapathway biotransformation Phase I and II |
| GO:0016229 | 3.32854782266e-07 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | steroid dehydrogenase activity |
| GO:0018636 | 3.84480164306e-07 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | phenanthrene 9,10-monooxygenase activity |
| REAC:R-HSA-8957322 | 8.43482117078e-07 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | Metabolism of steroids |
| GO:0009753 | 1.53784171933e-06 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | response to jasmonic acid |
| GO:0071395 | 1.53784171933e-06 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | cellular response to jasmonic acid stimulus |
| WP:WP98 | 2.08824407225e-06 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | Prostaglandin synthesis and regulation |
| GO:0047023 | 7.68841921772e-06 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | androsterone dehydrogenase activity |
| WP:WP4313 | 1.07545717909e-05 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | Ferroptosis |
| GO:0004497 | 1.37313780553e-05 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | monooxygenase activity |
| GO:0042448 | 2.15253635486e-05 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | progesterone metabolic process |
| WP:WP5277 | 2.55312309058e-05 | 0.5 | AKR1C1 AKR1D1 | Steroid hormone precursor biosynthesis |
| GO:0032052 | 3.22863876272e-05 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | bile acid binding |
| GO:0030647 | 3.22863876272e-05 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | aminoglycoside antibiotic metabolic process |
| GO:0044597 | 3.22863876272e-05 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | daunorubicin metabolic process |
| GO:0044598 | 4.61210427592e-05 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | doxorubicin metabolic process |
| GO:0030638 | 4.61210427592e-05 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | polyketide metabolic process |
| GO:0016616 | 0.000111817498921 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| GO:0071398 | 0.000139871762976 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | cellular response to fatty acid |
| GO:0016614 | 0.000151907686653 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | oxidoreductase activity, acting on CH-OH group of donors |
| GO:0016705 | 0.000195074084076 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| GO:1902644 | 0.000261258639543 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | tertiary alcohol metabolic process |
| GO:0016137 | 0.000261258639543 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | glycoside metabolic process |
| GO:0042445 | 0.000317929863268 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | hormone metabolic process |
| KEGG:05208 | 0.000459857531952 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | Chemical carcinogenesis - reactive oxygen species |
| GO:0016628 | 0.000510886175237 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor |
| GO:0070542 | 0.000510886175237 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | response to fatty acid |
| REAC:R-HSA-556833 | 0.000555830316912 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | Metabolism of lipids |
| GO:0033764 | 0.000680215375943 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| GO:0008202 | 0.00116366650227 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | steroid metabolic process |
| GO:0006693 | 0.00190418300832 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | prostaglandin metabolic process |
| GO:0006692 | 0.00209449363787 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | prostanoid metabolic process |
| GO:0006066 | 0.00249882623496 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | alcohol metabolic process |
| GO:0019748 | 0.00274053853655 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | secondary metabolic process |
| KEGG:01100 | 0.00275730008049 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | Metabolic pathways |
| GO:0047115 | 0.0028092043205 | 0.5 | AKR1C1 AKR1C2 | trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity |
| GO:1901661 | 0.00298219742351 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | quinone metabolic process |
| GO:0010817 | 0.00553001869835 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | regulation of hormone levels |
| GO:0016627 | 0.00582352741409 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | oxidoreductase activity, acting on the CH-CH group of donors |
| REAC:R-HSA-975634 | 0.0079693038543 | 0.5 | AKR1C1 AKR1C3 | Retinoid metabolism and transport |
| GO:0071799 | 0.00842684400117 | 0.5 | AKR1C2 AKR1C3 | cellular response to prostaglandin D stimulus |
| GO:0071798 | 0.00842684400117 | 0.5 | AKR1C2 AKR1C3 | response to prostaglandin D |
| GO:0007586 | 0.0089837173405 | 0.75 | AKR1C1 AKR1C2 AKR1D1 | digestion |
| REAC:R-HSA-6806667 | 0.00922347264132 | 0.5 | AKR1C1 AKR1C3 | Metabolism of fat-soluble vitamins |
| GO:1901657 | 0.0106287970558 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | glycosyl compound metabolic process |
| GO:0016655 | 0.0106287970558 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
| GO:1901615 | 0.0111408206209 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | organic hydroxy compound metabolic process |
| GO:0033293 | 0.0112187083505 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | monocarboxylic acid binding |
| GO:0034308 | 0.0112187083505 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | primary alcohol metabolic process |
| GO:0016651 | 0.0248327141789 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | oxidoreductase activity, acting on NAD(P)H |
| REAC:R-HSA-2187338 | 0.0305753786405 | 0.5 | AKR1C1 AKR1C3 | Visual phototransduction |
| GO:0033559 | 0.0314640437065 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | unsaturated fatty acid metabolic process |
| GO:0032787 | 0.0317425976647 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | monocarboxylic acid metabolic process |
| GO:0006690 | 0.0351813641256 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | icosanoid metabolic process |
| REAC:R-HSA-1430728 | 0.0393174957935 | 1.0 | AKR1C1 AKR1C2 AKR1C3 AKR1D1 | Metabolism |
| GO:0071379 | 0.042122686785 | 0.5 | AKR1C2 AKR1C3 | cellular response to prostaglandin stimulus |
| HPA:0290403 | 0.0452634487734 | 0.75 | AKR1C1 AKR1C3 AKR1C2 | liver; hepatocytes[High] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| AKR1C2 | AKR1C3 | 1.0 | 0.672 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| AKR1C1 | AKR1C2 | 0.999 | 0.196 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| AKR1C1 | AKR1D1 | 0.997 | 0.238 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| AKR1D1 | AKR1C3 | 0.997 | 0.54 |
structurally_consistent (Q04828)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| AKR1C1 | AKR1C3 | 0.997 | 0.348 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM treiber_WMM |
| AKR1D1 | AKR1C2 | 0.378 | 0.432 |
structurally_consistent (Q04828)
|
bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| AKR1C1 | huMAP3_01225.1 huMAP3_08762.1 huMAP3_10318.1 |
| AKR1D1 | huMAP3_01225.1 huMAP3_08762.1 huMAP3_10318.1 |
| AKR1C2 | huMAP3_01225.1 huMAP3_10318.1 |
| AKR1C3 | huMAP3_01225.1 huMAP3_08762.1 huMAP3_10318.1 |