hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_01249.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ATG14 | Beclin 1-associated autophagy-related key regulator (Barkor) (Autophagy-related protein 14-like protein) (Atg14L) | 5 | UniProt NCBI |
| BECN1 | Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa] | 5 | UniProt NCBI |
| NRBF2 | Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR) | 5 | UniProt NCBI |
| RUBCN | Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) | 5 | UniProt NCBI |
| PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34) | 5 | UniProt NCBI |
| PIK3R4 | Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) | 5 | UniProt NCBI |
| RUBCNL | Protein associated with UVRAG as autophagy enhancer (Pacer) (Protein Rubicon-like) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0035032 | 3.97003041564e-12 | 0.714285714286 | PIK3R4 ATG14 PIK3C3 BECN1 NRBF2 | phosphatidylinositol 3-kinase complex, class III |
| GO:0097352 | 3.61062217844e-10 | 0.857142857143 | ATG14 BECN1 RUBCNL PIK3R4 RUBCN PIK3C3 | autophagosome maturation |
| KEGG:04140 | 4.86413161942e-10 | 0.857142857143 | ATG14 NRBF2 BECN1 PIK3R4 RUBCN PIK3C3 | Autophagy - animal |
| GO:0005942 | 1.00235603606e-08 | 0.714285714286 | PIK3R4 ATG14 PIK3C3 BECN1 NRBF2 | phosphatidylinositol 3-kinase complex |
| CORUM:6472 | 2.80877722849e-08 | 0.428571428571 | PIK3R4 BECN1 PIK3C3 | Bcl-2-Beclin1-UVRAG-PI(3)KC3 complex |
| WP:WP4923 | 3.40254542507e-08 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | Autophagy |
| KEGG:05017 | 4.56608189276e-08 | 0.714285714286 | PIK3R4 ATG14 PIK3C3 BECN1 NRBF2 | Spinocerebellar ataxia |
| REAC:R-HSA-983170 | 6.24091028415e-08 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| WP:WP4577 | 1.5157281404e-07 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | Neurodegeneration with brain iron accumulation NBIA subtypes pathway |
| GO:0036092 | 1.93207287326e-07 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | phosphatidylinositol-3-phosphate biosynthetic process |
| GO:0006914 | 1.19578289286e-06 | 1.0 | ATG14 NRBF2 BECN1 RUBCNL PIK3R4 RUBCN PIK3C3 | autophagy |
| GO:0061919 | 1.19578289286e-06 | 1.0 | ATG14 NRBF2 BECN1 RUBCNL PIK3R4 RUBCN PIK3C3 | process utilizing autophagic mechanism |
| WP:WP5124 | 1.75154609698e-06 | 0.714285714286 | PIK3R4 ATG14 PIK3C3 BECN1 NRBF2 | Alzheimer 39 s disease |
| WP:WP2059 | 1.75154609698e-06 | 0.714285714286 | PIK3R4 ATG14 PIK3C3 BECN1 NRBF2 | Alzheimer 39 s disease and miRNA effects |
| GO:0032984 | 1.86567783047e-06 | 0.857142857143 | ATG14 BECN1 RUBCNL PIK3R4 RUBCN PIK3C3 | protein-containing complex disassembly |
| REAC:R-HSA-9679504 | 2.1479923589e-06 | 0.428571428571 | PIK3R4 BECN1 PIK3C3 | Translation of Replicase and Assembly of the Replication Transcription Complex |
| KEGG:05016 | 2.24688772699e-06 | 0.714285714286 | PIK3R4 ATG14 PIK3C3 BECN1 NRBF2 | Huntington disease |
| REAC:R-HSA-9694676 | 2.86340161093e-06 | 0.428571428571 | PIK3R4 BECN1 PIK3C3 | Translation of Replicase and Assembly of the Replication Transcription Complex |
| GO:0034272 | 3.36420143768e-06 | 0.428571428571 | PIK3R4 BECN1 PIK3C3 | phosphatidylinositol 3-kinase complex, class III, type II |
| GO:0034271 | 3.36420143768e-06 | 0.428571428571 | PIK3R4 BECN1 PIK3C3 | phosphatidylinositol 3-kinase complex, class III, type I |
| WP:WP4863 | 4.9578692769e-06 | 0.428571428571 | PIK3R4 BECN1 PIK3C3 | Host pathogen interaction of human coronaviruses autophagy |
| KEGG:05014 | 5.48831839723e-06 | 0.714285714286 | PIK3R4 ATG14 PIK3C3 BECN1 NRBF2 | Amyotrophic lateral sclerosis |
| KEGG:05010 | 6.98132804135e-06 | 0.714285714286 | PIK3R4 ATG14 PIK3C3 BECN1 NRBF2 | Alzheimer disease |
| GO:0006622 | 9.75381672605e-06 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | protein targeting to lysosome |
| GO:0016236 | 1.3861662121e-05 | 0.857142857143 | ATG14 BECN1 RUBCNL PIK3R4 RUBCN PIK3C3 | macroautophagy |
| KEGG:04136 | 1.41786055432e-05 | 0.428571428571 | PIK3R4 BECN1 PIK3C3 | Autophagy - other |
| KEGG:05022 | 1.86253065411e-05 | 0.714285714286 | PIK3R4 ATG14 PIK3C3 BECN1 NRBF2 | Pathways of neurodegeneration - multiple diseases |
| CORUM:429 | 2.05265451394e-05 | 0.285714285714 | PIK3C3 PIK3R4 | Phosphatidylinositol 3-kinase complex (PIK3C3, PIK3R4) |
| REAC:R-HSA-9705671 | 2.177889083e-05 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| REAC:R-HSA-1632852 | 3.5016953291e-05 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | Macroautophagy |
| REAC:R-HSA-9612973 | 5.50598372696e-05 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | Autophagy |
| GO:0006623 | 6.04945225324e-05 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | protein targeting to vacuole |
| GO:0016241 | 6.22047022865e-05 | 0.714285714286 | PIK3R4 ATG14 PIK3C3 BECN1 RUBCN | regulation of macroautophagy |
| GO:0045022 | 6.76004009067e-05 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | early endosome to late endosome transport |
| REAC:R-HSA-9772572 | 7.07065782066e-05 | 0.428571428571 | PIK3R4 BECN1 PIK3C3 | Early SARS-CoV-2 Infection Events |
| GO:0019898 | 8.04804550787e-05 | 0.714285714286 | PIK3R4 ATG14 PIK3C3 BECN1 NRBF2 | extrinsic component of membrane |
| GO:0042149 | 8.36681933501e-05 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | cellular response to glucose starvation |
| KEGG:05131 | 9.98209485344e-05 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | Shigellosis |
| GO:0098927 | 0.000102438985779 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | vesicle-mediated transport between endosomal compartments |
| CORUM:6816 | 0.000123103089524 | 0.285714285714 | ATG14 PIK3C3 | ULK1-ATG13-ATG14-PIK3C3 complex |
| GO:0022411 | 0.000151511253201 | 0.857142857143 | ATG14 BECN1 RUBCNL PIK3R4 RUBCN PIK3C3 | cellular component disassembly |
| GO:0046854 | 0.000163106388622 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | phosphatidylinositol phosphate biosynthetic process |
| REAC:R-HSA-9705683 | 0.00017454112665 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | SARS-CoV-2-host interactions |
| GO:0061462 | 0.000210494508038 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | protein localization to lysosome |
| GO:0072666 | 0.000267510262991 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | establishment of protein localization to vacuole |
| WP:WP5420 | 0.000302107483407 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | ADHD and autism ASD linked metabolic pathways and SNP |
| KEGG:04371 | 0.00076182524647 | 0.428571428571 | PIK3R4 BECN1 PIK3C3 | Apelin signaling pathway |
| REAC:R-HSA-9694516 | 0.000772937908588 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | SARS-CoV-2 Infection |
| GO:0072665 | 0.00110635664514 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | protein localization to vacuole |
| GO:0044248 | 0.00111325498785 | 1.0 | ATG14 NRBF2 BECN1 RUBCNL PIK3R4 RUBCN PIK3C3 | cellular catabolic process |
| GO:0005776 | 0.00116762839146 | 0.571428571429 | ATG14 RUBCNL BECN1 PIK3C3 | autophagosome |
| REAC:R-HSA-983169 | 0.00197942430213 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | Class I MHC mediated antigen processing & presentation |
| REAC:R-HSA-1660517 | 0.00209171533568 | 0.285714285714 | PIK3C3 PIK3R4 | Synthesis of PIPs at the late endosome membrane |
| GO:0061695 | 0.00235878261657 | 0.714285714286 | PIK3R4 ATG14 PIK3C3 BECN1 NRBF2 | transferase complex, transferring phosphorus-containing groups |
| KEGG:05167 | 0.0026347269947 | 0.428571428571 | ATG14 BECN1 PIK3C3 | Kaposi sarcoma-associated herpesvirus infection |
| REAC:R-HSA-9679506 | 0.0027504989814 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | SARS-CoV Infections |
| GO:0010506 | 0.003180883993 | 0.714285714286 | PIK3R4 ATG14 PIK3C3 BECN1 RUBCN | regulation of autophagy |
| REAC:R-HSA-1660516 | 0.00398963152505 | 0.285714285714 | PIK3C3 PIK3R4 | Synthesis of PIPs at the early endosome membrane |
| WP:WP2509 | 0.00409583359214 | 0.285714285714 | ATG14 BECN1 | Nanoparticle triggered autophagic cell death |
| GO:0007041 | 0.00449874442284 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | lysosomal transport |
| REAC:R-HSA-1660514 | 0.00455853850403 | 0.285714285714 | PIK3C3 PIK3R4 | Synthesis of PIPs at the Golgi membrane |
| GO:0006661 | 0.004672681336 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | phosphatidylinositol biosynthetic process |
| REAC:R-HSA-9678108 | 0.00475735783939 | 0.428571428571 | PIK3R4 BECN1 PIK3C3 | SARS-CoV-1 Infection |
| GO:0009267 | 0.00717572690708 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | cellular response to starvation |
| REAC:R-HSA-5668599 | 0.00796834465067 | 0.285714285714 | PIK3C3 PIK3R4 | RHO GTPases Activate NADPH Oxidases |
| GO:0046488 | 0.00874901431253 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | phosphatidylinositol metabolic process |
| GO:0007034 | 0.0108952763413 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | vacuolar transport |
| GO:0042594 | 0.0122857546787 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | response to starvation |
| REAC:R-HSA-109704 | 0.0133002920771 | 0.285714285714 | PIK3C3 PIK3R4 | PI3K Cascade |
| WP:WP4971 | 0.0151967459334 | 0.285714285714 | PIK3C3 PIK3R4 | Phosphoinositides metabolism |
| REAC:R-HSA-112399 | 0.0164719839916 | 0.285714285714 | PIK3C3 PIK3R4 | IRS-mediated signalling |
| GO:0000407 | 0.016587316136 | 0.428571428571 | ATG14 BECN1 PIK3C3 | phagophore assembly site |
| REAC:R-HSA-2404192 | 0.0199798926111 | 0.285714285714 | PIK3C3 PIK3R4 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| REAC:R-HSA-2428928 | 0.0199798926111 | 0.285714285714 | PIK3C3 PIK3R4 | IRS-related events triggered by IGF1R |
| REAC:R-HSA-2428924 | 0.0199798926111 | 0.285714285714 | PIK3C3 PIK3R4 | IGF1R signaling cascade |
| REAC:R-HSA-74751 | 0.0238233224402 | 0.285714285714 | PIK3C3 PIK3R4 | Insulin receptor signalling cascade |
| GO:0031669 | 0.02419782013 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | cellular response to nutrient levels |
| REAC:R-HSA-1280218 | 0.0256603099606 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | Adaptive Immune System |
| GO:0046474 | 0.0280218637102 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | glycerophospholipid biosynthetic process |
| GO:0009056 | 0.028112009769 | 1.0 | ATG14 NRBF2 BECN1 RUBCNL PIK3R4 RUBCN PIK3C3 | catabolic process |
| GO:0031668 | 0.0300947153732 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | cellular response to extracellular stimulus |
| REAC:R-HSA-9824446 | 0.0320441838438 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | Viral Infection Pathways |
| WP:WP5205 | 0.039968890476 | 0.285714285714 | BECN1 PIK3C3 | Clock controlled autophagy in bone metabolism |
| GO:0043491 | 0.0422241953008 | 0.571428571429 | PIK3R4 ATG14 BECN1 RUBCN | phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| WP:WP5156 | 0.0433840554919 | 0.142857142857 | PIK3R4 | SARS CoV 2 replication organelle formation |
| GO:0008654 | 0.0469790462071 | 0.571428571429 | PIK3R4 ATG14 BECN1 PIK3C3 | phospholipid biosynthetic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PIK3C3 | PIK3R4 | 0.999 | 0.316 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM Malo fraction |
| BECN1 | PIK3C3 | 0.999 | 0.138 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| ATG14 | BECN1 | 0.997 | 0.174 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| PIK3C3 | RUBCNL | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| BECN1 | PIK3R4 | 0.997 | 0.274 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| RUBCN | PIK3R4 | 0.996 | 0.182 | hein_WMM bioplex3_HEK293 bioplex3_WMM WMM_only |
| ATG14 | PIK3C3 | 0.996 | 0.156 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NRBF2 | PIK3C3 | 0.995 | 0.152 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| NRBF2 | PIK3R4 | 0.995 | 0.134 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| BECN1 | RUBCN | 0.994 | 0.154 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () |
| BECN1 | RUBCNL | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ATG14 | NRBF2 | 0.993 | 0.124 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ATG14 | PIK3R4 | 0.992 | 0.24 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RUBCN | PIK3C3 | 0.992 | 0.076 | hein_WMM bioplex3_HEK293 bioplex3_WMM WMM_only |
| BECN1 | NRBF2 | 0.992 | 0.24225 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| PIK3R4 | RUBCNL | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NRBF2 | RUBCN | 0.315 | 0.122 | hein_WMM WMM_only |
| ATG14 | RUBCN | 0.315 | 0.134 | hein_WMM WMM_only |
Related Complexes