hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01257.1
Complex Portal: CPX-22986
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FAR2 | Fatty acyl-CoA reductase 2 (EC 1.2.1.84) (Male sterility domain-containing protein 1) | 5 | UniProt NCBI |
| STEAP3 | Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) | 5 | UniProt NCBI |
| ATP2B2 | Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2) | 5 | UniProt NCBI |
| ATP2B3 | Plasma membrane calcium-transporting ATPase 3 (PMCA3) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 3) (Plasma membrane calcium pump isoform 3) | 5 | UniProt NCBI |
| HSD17B6 | 17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6) (17-beta-HSD6) (EC 1.1.1.105) (EC 1.1.1.209) (EC 1.1.1.239) (EC 1.1.1.53) (EC 1.1.1.62) (3-alpha->beta-hydroxysteroid epimerase) (3-alpha->beta-HSE) (Oxidative 3-alpha hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 6) | 5 | UniProt NCBI |
| SLAMF1 | Signaling lymphocytic activation molecule (CDw150) (IPO-3) (SLAM family member 1) (CD antigen CD150) | 5 | UniProt NCBI |
| MPC2 | Mitochondrial pyruvate carrier 2 (Brain protein 44) | 5 | UniProt NCBI |
| C17orf78 | Uncharacterized protein C17orf78 | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-418359 | 0.0030606580132 | 0.25 | ATP2B2 ATP2B3 | Reduction of cytosolic Ca++ levels |
| WP:WP4698 | 0.00833957037235 | 0.25 | ATP2B2 ATP2B3 | Vitamin D sensitive calcium signaling in depression |
| KEGG:04961 | 0.0138593269366 | 0.25 | ATP2B2 ATP2B3 | Endocrine and other factor-regulated calcium reabsorption |
| KEGG:04978 | 0.0138593269366 | 0.25 | ATP2B2 ATP2B3 | Mineral absorption |
| REAC:R-HSA-418360 | 0.0140328389809 | 0.25 | ATP2B2 ATP2B3 | Platelet calcium homeostasis |
| KEGG:04970 | 0.0257266913769 | 0.25 | ATP2B2 ATP2B3 | Salivary secretion |
| KEGG:04972 | 0.032546331302 | 0.25 | ATP2B2 ATP2B3 | Pancreatic secretion |
| KEGG:04925 | 0.0343738123186 | 0.25 | ATP2B2 ATP2B3 | Aldosterone synthesis and secretion |
| REAC:R-HSA-936837 | 0.0388325640363 | 0.25 | ATP2B2 ATP2B3 | Ion transport by P-type ATPases |
| REAC:R-HSA-5578775 | 0.0452582424141 | 0.25 | ATP2B2 ATP2B3 | Ion homeostasis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ATP2B2 | HSD17B6 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ATP2B2 | ATP2B3 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| FAR2 | ATP2B2 | 0.997 | 0.076 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ATP2B2 | C17orf78 | 0.994 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ATP2B3 | C17orf78 | 0.991 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| MPC2 | ATP2B2 | 0.99 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ATP2B3 | HSD17B6 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| STEAP3 | ATP2B2 | 0.971 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SLAMF1 | ATP2B2 | 0.952 | bioplex3_HEK293 bioplex3_WMM bioplex () bioplex3_HCT116 bioplex_WMM | ||
| FAR2 | HSD17B6 | 0.718 | bioplex_WMM bioplex3_WMM WMM_only | ||
| STEAP3 | FAR2 | 0.225 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only | |
| STEAP3 | HSD17B6 | 0.187 | bioplex_WMM bioplex3_WMM WMM_only | ||
| FAR2 | ATP2B3 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | ||
| STEAP3 | ATP2B3 | 0.115 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MPC2 | HSD17B6 | 0.098 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MPC2 | FAR2 | 0.084 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only | |
| SLAMF1 | FAR2 | 0.072 | 0.068 | bioplex () bioplex_WMM | |
| MPC2 | ATP2B3 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SLAMF1 | ATP2B3 | 0.053 | bioplex3_HEK293 bioplex3_WMM bioplex () bioplex_WMM | ||
| MPC2 | STEAP3 | 0.012 | 0.026 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
Related Complexes