hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_01259.1
Complex Portal: CPX-21232
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| BMPR2 | Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) | 5 | UniProt NCBI |
| ACVR1 | Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04350 | 0.000608173227025 | 1.0 | BMPR2 ACVR1 | TGF-beta signaling pathway |
| KEGG:05418 | 0.0011031979467 | 1.0 | BMPR2 ACVR1 | Fluid shear stress and atherosclerosis |
| KEGG:04550 | 0.00116074761854 | 1.0 | BMPR2 ACVR1 | Signaling pathways regulating pluripotency of stem cells |
| WP:WP3931 | 0.00210690324038 | 1.0 | BMPR2 ACVR1 | Embryonic stem cell pluripotency pathways |
| KEGG:04060 | 0.0031385705215 | 1.0 | BMPR2 ACVR1 | Cytokine-cytokine receptor interaction |
| WP:WP2857 | 0.00340552178308 | 1.0 | BMPR2 ACVR1 | Mesodermal commitment pathway |
| GO:0098821 | 0.00702301080125 | 1.0 | BMPR2 ACVR1 | BMP receptor activity |
| GO:0003174 | 0.0131096201623 | 1.0 | BMPR2 ACVR1 | mitral valve development |
| GO:0003183 | 0.0131096201623 | 1.0 | BMPR2 ACVR1 | mitral valve morphogenesis |
| GO:0017002 | 0.0131096201623 | 1.0 | BMPR2 ACVR1 | activin receptor activity |
| GO:0060413 | 0.0210690324038 | 1.0 | BMPR2 ACVR1 | atrial septum morphogenesis |
| GO:0005024 | 0.0257510396046 | 1.0 | BMPR2 ACVR1 | transforming growth factor beta receptor activity |
| GO:0003283 | 0.0365196561665 | 1.0 | BMPR2 ACVR1 | atrial septum development |
| GO:0004675 | 0.0426062655276 | 1.0 | BMPR2 ACVR1 | transmembrane receptor protein serine/threonine kinase activity |
| GO:0003209 | 0.0491610756088 | 1.0 | BMPR2 ACVR1 | cardiac atrium morphogenesis |
| HP:0005312 | 0.0499436884913 | 0.5 | BMPR2 | Pulmonary aterial intimal fibrosis |
| HP:0008449 | 0.0499436884913 | 0.5 | ACVR1 | Progressive cervical vertebral spine fusion |
| HP:0011353 | 0.0499436884913 | 0.5 | BMPR2 | Arterial intimal fibrosis |
| HP:0011987 | 0.0499436884913 | 0.5 | ACVR1 | Ectopic ossification in muscle tissue |
| HP:0011988 | 0.0499436884913 | 0.5 | ACVR1 | Ectopic ossification in tendon tissue |
| HP:0011989 | 0.0499436884913 | 0.5 | ACVR1 | Ectopic ossification in ligament tissue |
| HP:0025443 | 0.0499436884913 | 0.5 | BMPR2 | Abnormal cardiac atrial physiology |
| HP:0030967 | 0.0499436884913 | 0.5 | BMPR2 | Abnormal pulmonary artery physiology |
| HP:0005168 | 0.0499436884913 | 0.5 | BMPR2 | Elevated right atrial pressure |
| HP:0005308 | 0.0499436884913 | 0.5 | BMPR2 | Pulmonary artery vasoconstriction |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| BMPR2 | ACVR1 | 0.988 | 0.176 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes