hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_01262.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PTP4A1 | Protein tyrosine phosphatase type IVA 1 (EC 3.1.3.48) (PTP(CAAXI)) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1) | 5 | UniProt NCBI |
| DGKZ | Diacylglycerol kinase zeta (DAG kinase zeta) (EC 2.7.1.107) (EC 2.7.1.93) (Diglyceride kinase zeta) (DGK-zeta) | 5 | UniProt NCBI |
| FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha) | 5 | UniProt NCBI |
| FNTB | Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:419 | 5.12628525639e-06 | 0.5 | FNTA FNTB | Farnesyltransferase |
| KEGG:00900 | 0.000578341586214 | 0.5 | FNTA FNTB | Terpenoid backbone biosynthesis |
| REAC:R-HSA-9648002 | 0.00236402400204 | 0.5 | FNTA FNTB | RAS processing |
| REAC:R-HSA-2514859 | 0.00258893271292 | 0.5 | FNTA FNTB | Inactivation, recovery and regulation of the phototransduction cascade |
| REAC:R-HSA-2514856 | 0.00258893271292 | 0.5 | FNTA FNTB | The phototransduction cascade |
| GO:0004660 | 0.0028092043205 | 0.5 | FNTA FNTB | protein farnesyltransferase activity |
| GO:0005965 | 0.0028092043205 | 0.5 | FNTA FNTB | protein farnesyltransferase complex |
| GO:0018343 | 0.00842684400117 | 0.5 | FNTA FNTB | protein farnesylation |
| REAC:R-HSA-2187338 | 0.0305753786405 | 0.5 | FNTA FNTB | Visual phototransduction |
| REAC:R-HSA-9679191 | 0.0363250695065 | 0.5 | FNTA FNTB | Potential therapeutics for SARS |
| GO:0008318 | 0.042122686785 | 0.5 | FNTA FNTB | protein prenyltransferase activity |
| CORUM:6219 | 0.049938562206 | 0.25 | DGKZ | DGKZ-RASGRP1-HRAS complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| FNTA | FNTB | 1.0 | 0.33 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM |
| DGKZ | FNTB | 0.992 | 0.156 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| PTP4A1 | FNTA | 0.988 | 0.016 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| PTP4A1 | FNTB | 0.983 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| FNTA | DGKZ | 0.982 | 0.088 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes