hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01270.1
Complex Portal: CPX-17727
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SPG21 | Maspardin (Acid cluster protein 33) (Spastic paraplegia 21 autosomal recessive Mast syndrome protein) (Spastic paraplegia 21 protein) | 5 | UniProt NCBI |
| ATPAF2 | ATP synthase mitochondrial F1 complex assembly factor 2 (ATP12 homolog) | 5 | UniProt NCBI |
| HMGCL | Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0034353 | 0.00587504741878 | 1.0 | SPG21 HMGCL ATPAF2 | Appendicular spasticity |
| HP:0010549 | 0.0121271789544 | 1.0 | SPG21 HMGCL ATPAF2 | Weakness due to upper motor neuron dysfunction |
| HP:0001260 | 0.0202930882181 | 1.0 | SPG21 HMGCL ATPAF2 | Dysarthria |
| HP:0000745 | 0.0234917943256 | 1.0 | SPG21 HMGCL ATPAF2 | Diminished motivation |
| HP:5200275 | 0.0244069601643 | 1.0 | SPG21 HMGCL ATPAF2 | Abnormal motivation |
| HP:0001987 | 0.0331471884053 | 0.666666666667 | ATPAF2 HMGCL | Hyperammonemia |
| WP:WP311 | 0.0413734636003 | 0.333333333333 | HMGCL | Ketone bodies synthesis and degradation |
| WP:WP5175 | 0.0413734636003 | 0.333333333333 | HMGCL | Disorders in ketone body synthesis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SPG21 | ATPAF2 | 0.997 | 0.042 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| HMGCL | ATPAF2 | 0.973 | 0.098 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes