hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_01270.1

Confidence: Extremely High

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Genename	Protein Name	Uniprot Annotation Score	Links
ATPAF2	ATP synthase mitochondrial F1 complex assembly factor 2 (ATP12 homolog)	5	UniProt NCBI
HMGCL	Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase)	5	UniProt NCBI
SPG21	Maspardin (Acid cluster protein 33) (Spastic paraplegia 21 autosomal recessive Mast syndrome protein) (Spastic paraplegia 21 protein)	5	UniProt NCBI

Showing 1 to 3 of 3 entries

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Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
HP:0034353	0.00587504741878	1.0	SPG21 ATPAF2 HMGCL	Appendicular spasticity
HP:0010549	0.0121271789544	1.0	SPG21 ATPAF2 HMGCL	Weakness due to upper motor neuron dysfunction
HP:0001260	0.0202930882181	1.0	SPG21 ATPAF2 HMGCL	Dysarthria
HP:0000745	0.0234917943256	1.0	SPG21 ATPAF2 HMGCL	Diminished motivation
HP:5200275	0.0244069601643	1.0	SPG21 ATPAF2 HMGCL	Abnormal motivation
HP:0001987	0.0331471884053	0.666666666667	HMGCL ATPAF2	Hyperammonemia
WP:WP311	0.0413734636003	0.333333333333	HMGCL	Ketone bodies synthesis and degradation
WP:WP5175	0.0413734636003	0.333333333333	HMGCL	Disorders in ketone body synthesis

Showing 1 to 8 of 8 entries

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Protein 1	Protein 2	Score	ProteomeHD	Evidence
SPG21	ATPAF2	0.997	0.042	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
HMGCL	ATPAF2	0.973	0.098	bioplex3_WMM bioplex3_HCT116 WMM_only

Showing 1 to 2 of 2 entries

Related Complexes

Genename	Complexes
SPG21	huMAP3_00130.1 huMAP3_01270.1 huMAP3_02580.1 huMAP3_06661.1 huMAP3_08552.1 huMAP3_09533.1 huMAP3_11528.1 huMAP3_13718.1
ATPAF2	huMAP3_01270.1 huMAP3_06661.1 huMAP3_09533.1 huMAP3_11528.1 huMAP3_13468.1
HMGCL	huMAP3_00763.1 huMAP3_01270.1 huMAP3_06745.1 huMAP3_09533.1 huMAP3_10908.1 huMAP3_13468.1