hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01277.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| VPS26B | Vacuolar protein sorting-associated protein 26B (Vesicle protein sorting 26B) | 3 | UniProt NCBI |
| VPS26A | Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26) | 5 | UniProt NCBI |
| VPS29 | Vacuolar protein sorting-associated protein 29 (hVPS29) (PEP11 homolog) (Vesicle protein sorting 29) | 5 | UniProt NCBI |
| ANKRD27 | Ankyrin repeat domain-containing protein 27 (VPS9 domain-containing protein) | 5 | UniProt NCBI |
| VPS35 | Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35) | 5 | UniProt NCBI |
| TBC1D5 | TBC1 domain family member 5 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0030906 | 3.94689465137e-10 | 0.666666666667 | VPS26A VPS35 VPS26B VPS29 | retromer, cargo-selective complex |
| GO:0030904 | 6.27716685072e-10 | 0.833333333333 | VPS26A VPS35 VPS26B TBC1D5 VPS29 | retromer complex |
| CORUM:656 | 4.67737426163e-09 | 0.5 | VPS26A VPS35 VPS29 | VPS35-VPS29-VPS26A complex |
| CORUM:1060 | 4.675933868e-08 | 0.5 | VPS29 VPS26B VPS35 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26B) |
| CORUM:657 | 4.675933868e-08 | 0.5 | VPS26A VPS35 VPS29 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) |
| CORUM:1059 | 4.675933868e-08 | 0.5 | VPS26A VPS35 VPS29 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) |
| GO:0016197 | 1.01873336054e-06 | 1.0 | VPS29 TBC1D5 VPS26A ANKRD27 VPS35 VPS26B | endosomal transport |
| GO:0042147 | 1.66038655046e-06 | 0.833333333333 | VPS26A VPS35 VPS26B TBC1D5 VPS29 | retrograde transport, endosome to Golgi |
| GO:0016482 | 9.80306376797e-06 | 0.833333333333 | VPS26A VPS35 VPS26B TBC1D5 VPS29 | cytosolic transport |
| REAC:R-HSA-3238698 | 1.62005905893e-05 | 0.5 | VPS26A VPS35 VPS29 | WNT ligand biogenesis and trafficking |
| GO:0097422 | 1.92180881975e-05 | 0.5 | VPS26A VPS35 ANKRD27 | tubular endosome |
| KEGG:04144 | 4.60592149141e-05 | 0.666666666667 | VPS26A VPS35 VPS26B VPS29 | Endocytosis |
| GO:0032456 | 0.000476002909429 | 0.666666666667 | VPS26A VPS35 ANKRD27 VPS29 | endocytic recycling |
| GO:0005768 | 0.000638687271276 | 1.0 | VPS29 TBC1D5 VPS26A ANKRD27 VPS35 VPS26B | endosome |
| GO:0098876 | 0.00428601543329 | 0.666666666667 | VPS26A VPS35 ANKRD27 VPS29 | vesicle-mediated transport to the plasma membrane |
| GO:0046907 | 0.008082403103 | 1.0 | VPS29 TBC1D5 VPS26A ANKRD27 VPS35 VPS26B | intracellular transport |
| GO:0016192 | 0.00887756788753 | 1.0 | VPS29 TBC1D5 VPS26A ANKRD27 VPS35 VPS26B | vesicle-mediated transport |
| REAC:R-HSA-195721 | 0.0291878756931 | 0.5 | VPS26A VPS35 VPS29 | Signaling by WNT |
| GO:0051649 | 0.0361725108126 | 1.0 | VPS29 TBC1D5 VPS26A ANKRD27 VPS35 VPS26B | establishment of localization in cell |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| VPS26B | VPS26A | 1.0 | 0.106 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| VPS26A | VPS29 | 1.0 | 0.838 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM fraction |
| VPS26B | VPS29 | 1.0 | 0.096 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM hein () bioplex3_HCT116 fraction boldt_WMM |
| VPS26A | VPS35 | 1.0 | 0.802 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM fraction |
| VPS26B | VPS35 | 1.0 | 0.084 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt hein () fraction boldt_WMM |
| VPS29 | VPS35 | 1.0 | 0.88 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| VPS26A | TBC1D5 | 1.0 | 0.112 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM |
| VPS29 | TBC1D5 | 1.0 | 0.094 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| VPS26B | TBC1D5 | 0.999 | 0.046 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| VPS35 | TBC1D5 | 0.999 | 0.142 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| VPS29 | ANKRD27 | 0.995 | 0.098 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ANKRD27 | VPS35 | 0.988 | 0.174 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| VPS26B | ANKRD27 | 0.985 | 0.04 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| VPS26A | ANKRD27 | 0.981 | 0.106 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| ANKRD27 | TBC1D5 | 0.945 | 0.082 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| VPS26B | huMAP3_01277.1 huMAP3_13244.1 |
| VPS26A | huMAP3_01277.1 huMAP3_13244.1 |
| VPS29 | huMAP3_01277.1 huMAP3_01290.1 huMAP3_07032.1 huMAP3_13244.1 huMAP3_14444.1 |
| ANKRD27 | huMAP3_01277.1 huMAP3_13244.1 huMAP3_14474.1 |
| VPS35 | huMAP3_01277.1 huMAP3_13244.1 |
| TBC1D5 | huMAP3_01277.1 huMAP3_13244.1 |