hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01278.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WTAP | Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (hFL(2)D) (WT1-associated protein) (Wilms tumor 1-associating protein) | 5 | UniProt NCBI |
| METTL14 | N6-adenosine-methyltransferase non-catalytic subunit (Methyltransferase-like protein 14) (hMETTL14) | 5 | UniProt NCBI |
| METTL3 | N6-adenosine-methyltransferase catalytic subunit (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N6-adenosine-methyltransferase 70 kDa subunit) (MT-A70) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0036396 | 5.38272230028e-06 | 1.0 | METTL14 WTAP METTL3 | RNA N6-methyladenosine methyltransferase complex |
| GO:0045293 | 2.74903317479e-05 | 1.0 | METTL14 WTAP METTL3 | mRNA editing complex |
| GO:0080009 | 6.5361627932e-05 | 1.0 | METTL14 WTAP METTL3 | mRNA methylation |
| GO:0016556 | 0.000314889254566 | 1.0 | METTL14 WTAP METTL3 | mRNA modification |
| REAC:R-HSA-72203 | 0.00158225905908 | 1.0 | METTL14 WTAP METTL3 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0021861 | 0.00421361424067 | 0.666666666667 | METTL14 METTL3 | forebrain radial glial cell differentiation |
| GO:0001510 | 0.00731242824493 | 1.0 | METTL14 WTAP METTL3 | RNA methylation |
| GO:0001734 | 0.00842684400117 | 0.666666666667 | METTL14 METTL3 | mRNA (N6-adenosine)-methyltransferase activity |
| GO:0034708 | 0.0116771431902 | 1.0 | METTL14 WTAP METTL3 | methyltransferase complex |
| GO:0060019 | 0.0140440992017 | 0.666666666667 | METTL14 METTL3 | radial glial cell differentiation |
| REAC:R-HSA-8953854 | 0.0247774527734 | 1.0 | METTL14 WTAP METTL3 | Metabolism of RNA |
| GO:0043414 | 0.0328130751425 | 1.0 | METTL14 WTAP METTL3 | macromolecule methylation |
| GO:0032259 | 0.0368433884648 | 1.0 | METTL14 WTAP METTL3 | methylation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| METTL14 | METTL3 | 1.0 | 0.214 | hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () Malo fraction |
| WTAP | METTL3 | 0.999 | 0.196 | hein_WMM bioplex_WMM youn_WMM hein () |
| WTAP | METTL14 | 0.986 | 0.238 | hein_WMM youn_WMM WMM_only |
Related Complexes