hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_01287.1

Complex Portal: CPX-13515

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
PHF12	PHD finger protein 12 (PHD factor 1) (Pf1)	5	UniProt NCBI
PHF21A	PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80)	5	UniProt NCBI
SFMBT1	Scm-like with four MBT domains protein 1 (hSFMBT) (Renal ubiquitous protein 1)	5	UniProt NCBI
MIER2	Mesoderm induction early response protein 2 (Mi-er2)	5	UniProt NCBI
HDAC1	Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)	5	UniProt NCBI
MIDEAS	Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1)	4	UniProt NCBI
CCDC71	Coiled-coil domain-containing protein 71	2	UniProt NCBI
GSE1	Genetic suppressor element 1	5	UniProt NCBI
PHF21B	PHD finger protein 21B	3	UniProt NCBI
TRERF1	Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132)	5	UniProt NCBI
CASP8AP2	CASP8-associated protein 2 (FLICE-associated huge protein)	5	UniProt NCBI
BAHCC1	BAH and coiled-coil domain-containing protein 1 (Bromo adjacent homology domain-containing protein 2) (BAH domain-containing protein 2)	3	UniProt NCBI
PWWP2A	PWWP domain-containing protein 2A	5	UniProt NCBI
HDAC2	Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)	5	UniProt NCBI
DNTTIP1	Deoxynucleotidyltransferase terminal-interacting protein 1 (Terminal deoxynucleotidyltransferase-interacting factor 1) (TdIF1) (TdT-interacting factor 1)	5	UniProt NCBI
HMG20B	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (SMARCE1-related protein) (BRCA2-associated factor 35) (HMG box-containing protein 20B) (HMG domain-containing protein 2) (HMG domain-containing protein HMGX2) (Sox-like transcriptional factor) (Structural DNA-binding protein BRAF35)	5	UniProt NCBI
RERE	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:1492	1.19600337757e-11	0.294117647059	PHF21A HDAC2 HMG20B HDAC1 GSE1	BHC110 complex
CORUM:633	2.19117176276e-11	0.294117647059	PHF21A HDAC2 HMG20B HDAC1 GSE1	anti-BHC110 complex
CORUM:6373	5.35248391468e-11	0.235294117647	HDAC2 DNTTIP1 HDAC1 MIDEAS	MiDAC complex
CORUM:632	2.92280605374e-10	0.294117647059	PHF21A HDAC2 HMG20B HDAC1 GSE1	Anti-HDAC2 complex
CORUM:636	8.0173002101e-10	0.235294117647	PHF21A HMG20B HDAC1 HDAC2	BHC complex
CORUM:871	1.86937175692e-09	0.235294117647	PHF21A HMG20B HDAC1 HDAC2	BRAF53-BRCA2 complex
CORUM:620	1.86937175692e-09	0.235294117647	PHF21A HMG20B HDAC1 HDAC2	CoREST-HDAC complex
GO:0000118	2.06869779679e-08	0.411764705882	TRERF1 DNTTIP1 PHF21A PHF12 HDAC1 HDAC2 MIDEAS	histone deacetylase complex
CORUM:626	3.80257658523e-08	0.235294117647	PHF21A HMG20B HDAC1 PHF21B	LSD1 complex
CORUM:6421	5.58646392581e-08	0.176470588235	HDAC2 HDAC1 DNTTIP1	DNTTIP1-ZNF541-HDAC1-HDAC2 complex
GO:0003714	1.40214579447e-05	0.411764705882	TRERF1 MIER2 PHF12 HDAC1 RERE MIDEAS SFMBT1	transcription corepressor activity
CORUM:3053	0.000163158265417	0.117647058824	HDAC2 HDAC1	mSin3A-HDAC1-HDAC2 complex
CORUM:2814	0.000163158265417	0.117647058824	HDAC2 HDAC1	BRCA1-HDAC1-HDAC2 complex
CORUM:749	0.000326093232852	0.117647058824	HDAC2 HDAC1	MeCP2-SIN3A-HDAC complex
CORUM:889	0.000543116825549	0.117647058824	HDAC2 HDAC1	MTA1-HDAC core complex
CORUM:3167	0.000543116825549	0.117647058824	HDAC2 HDAC1	NCOR-SIN3-HDAC-HESX1 complex
CORUM:634	0.000543116825549	0.117647058824	HDAC2 HDAC1	XFIM complex
CORUM:3048	0.000543116825549	0.117647058824	HDAC2 HDAC1	mSin3A complex
REAC:R-HSA-3214815	0.000605305571916	0.235294117647	PHF21A HMG20B HDAC1 HDAC2	HDACs deacetylate histones
REAC:R-HSA-9679191	0.000772170072379	0.235294117647	PHF21A HMG20B HDAC1 HDAC2	Potential therapeutics for SARS
CORUM:886	0.000814117795383	0.117647058824	HDAC2 HDAC1	MTA1 complex
CORUM:732	0.00113898505423	0.117647058824	HDAC2 HDAC1	SIN3 complex
CORUM:596	0.00113898505423	0.117647058824	HDAC2 HDAC1	SIN3-HDAC-SAP30-ARID4 complex
CORUM:614	0.00113898505423	0.117647058824	HDAC2 HDAC1	NRD complex (Nucleosome remodeling and deacetylation complex)
CORUM:698	0.00113898505423	0.117647058824	HDAC2 HDAC1	SIN3-HDAC-SAP30-ARID4 complex
CORUM:1505	0.00113898505423	0.117647058824	HDAC2 HDAC1	NCOR2 complex
CORUM:61	0.00113898505423	0.117647058824	HDAC2 HDAC1	Mi2/NuRD complex
CORUM:54	0.00113898505423	0.117647058824	HDAC2 HDAC1	SIN3 complex
CORUM:695	0.00113898505423	0.117647058824	HDAC2 HDAC1	SIN3-HDAC-SAP30-ARID4 complex
CORUM:283	0.00113898505423	0.117647058824	HDAC2 HDAC1	Sin3 complex
REAC:R-HSA-193670	0.00123158174541	0.117647058824	HDAC2 HDAC1	p75NTR negatively regulates cell cycle via SC1
CORUM:696	0.00151760767378	0.117647058824	HDAC2 HDAC1	BRMS1-SIN3-HDAC complex
CORUM:587	0.00151760767378	0.117647058824	HDAC2 HDAC1	NuRD.1 complex
CORUM:62	0.00151760767378	0.117647058824	HDAC2 HDAC1	MeCP1 complex
CORUM:591	0.00151760767378	0.117647058824	HDAC2 HDAC1	SAP complex (Sin3-associated protein complex)
CORUM:888	0.00151760767378	0.117647058824	HDAC2 HDAC1	MTA2 complex
CORUM:659	0.00194987488536	0.117647058824	HDAC2 HDAC1	MeCP1 complex
CORUM:643	0.00194987488536	0.117647058824	HDAC2 HDAC1	CtBP core complex
CORUM:592	0.00194987488536	0.117647058824	HDAC2 HDAC1	SAP complex (Sin3-associated protein complex)
CORUM:738	0.00194987488536	0.117647058824	HDAC2 HDAC1	SIN3-ING1b complex I
CORUM:685	0.00194987488536	0.117647058824	HDAC2 HDAC1	MeCP1 complex
CORUM:691	0.0024356760797	0.117647058824	HDAC2 HDAC1	SIN3-SAP25 complex
CORUM:743	0.0024356760797	0.117647058824	HDAC2 HDAC1	SIN3-SAP25 complex
CORUM:2851	0.00297490080681	0.117647058824	HDAC2 HDAC1	ING2 complex
CORUM:714	0.00566383160577	0.117647058824	HDAC2 HDAC1	BRM-SIN3A complex
KEGG:03083	0.00636007547024	0.176470588235	HDAC2 SFMBT1 HDAC1	Polycomb repressive complex
CORUM:2721	0.00646852280697	0.117647058824	HDAC2 HDAC1	HCF-1 complex
CORUM:739	0.00646852280697	0.117647058824	HDAC2 HDAC1	SIN3-ING1b complex II
CORUM:282	0.00646852280697	0.117647058824	HDAC2 HDAC1	SNF2h-cohesin-NuRD complex
CORUM:642	0.00732597817448	0.117647058824	HDAC2 HDAC1	CtBP complex
TF:M12464_1	0.0075079154971	0.705882352941	TRERF1 PHF21A HMG20B GSE1 CCDC71 PHF12 HDAC1 PWWP2A MIER2 PHF21B MIDEAS BAHCC1	Factor: ZNF148; motif: NNCCCCTCCCCC; match class: 1
REAC:R-HSA-983231	0.00882397852872	0.235294117647	PHF21A HMG20B HDAC1 HDAC2	Factors involved in megakaryocyte development and platelet production
CORUM:778	0.00919874420385	0.117647058824	HDAC2 HDAC1	LARC complex (LCR-associated remodeling complex)
GO:0003712	0.0111179812739	0.411764705882	TRERF1 MIER2 PHF12 HDAC1 RERE MIDEAS SFMBT1	transcription coregulator activity
REAC:R-HSA-9701898	0.0183854258919	0.117647058824	HDAC2 HDAC1	STAT3 nuclear events downstream of ALK signaling
CORUM:1257	0.0202092633303	0.117647058824	HDAC2 HDAC1	ALL-1 supercomplex
REAC:R-HSA-9022699	0.0427527934113	0.117647058824	HDAC2 HDAC1	MECP2 regulates neuronal receptors and channels
GO:0004407	0.04400083428	0.176470588235	HDAC2 MIER2 HDAC1	histone deacetylase activity

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
HMG20B	GSE1	1.0	0.058
MIER2	HDAC1	1.0	0.082	structurally_consistent (dimer)
MIER2	HDAC2	1.0	0.358	mutually_exclusive (Q13547) structurally_consistent (dimer)
HDAC1	HDAC2	1.0	0.468	structurally_consistent (dimer)
HDAC1	GSE1	1.0	0.088	structurally_consistent (dimer)
HMG20B	PHF21A	1.0	0.252
HMG20B	HDAC2	1.0	0.352	structurally_consistent (dimer)
PHF12	HDAC1	0.999	0.208
MIDEAS	DNTTIP1	0.999	0.378	mutually_exclusive (Q92769)
HMG20B	HDAC1	0.999	0.15
MIDEAS	HDAC1	0.998	0.128	structurally_consistent (dimer)
HDAC1	TRERF1	0.997		structurally_consistent (dimer)
HDAC1	DNTTIP1	0.997	0.344	mutually_exclusive (Q92769) structurally_consistent (dimer)
TRERF1	DNTTIP1	0.994
PHF21A	GSE1	0.994	0.1	mutually_exclusive (Q13547)
BAHCC1	HDAC2	0.993
RERE	HDAC1	0.992	0.318
TRERF1	HDAC2	0.992		mutually_exclusive (Q13547)
BAHCC1	HDAC1	0.992
PHF21A	HDAC1	0.992	0.196	mutually_exclusive (O60341) structurally_consistent (dimer)
MIDEAS	PWWP2A	0.992	0.092
MIDEAS	TRERF1	0.99		mutually_exclusive (Q13547)
TRERF1	PWWP2A	0.987
PWWP2A	DNTTIP1	0.984	0.212
MIDEAS	HDAC2	0.984	0.164	structurally_consistent (dimer)
SFMBT1	HDAC1	0.984	0.17106122449
BAHCC1	TRERF1	0.982
HDAC1	PWWP2A	0.981	0.11
RERE	BAHCC1	0.98
PHF12	HDAC2	0.978	0.29
HDAC1	CASP8AP2	0.977	0.256
HDAC1	PHF21B	0.976
HMG20B	BAHCC1	0.972
PHF12	TRERF1	0.968
CCDC71	HDAC1	0.967	0.118	structurally_consistent (dimer)
HMG20B	PWWP2A	0.967	0.12
RERE	PWWP2A	0.965	0.108
PHF12	GSE1	0.964	0.172
GSE1	HDAC2	0.959	0.242
GSE1	PWWP2A	0.957	0.058
RERE	PHF12	0.956	0.276
PHF12	HMG20B	0.956	0.238
HDAC2	DNTTIP1	0.926	0.148	structurally_consistent (dimer)
PHF21A	HDAC2	0.916	0.15
BAHCC1	GSE1	0.912
PHF12	BAHCC1	0.908
BAHCC1	PWWP2A	0.901
RERE	HMG20B	0.878	0.116
RERE	TRERF1	0.87
MIER2	TRERF1	0.868		mutually_exclusive (Q13547)
PWWP2A	HDAC2	0.84	0.122
PHF12	PWWP2A	0.835	0.108
HMG20B	TRERF1	0.832
GSE1	TRERF1	0.806
BAHCC1	DNTTIP1	0.804
PHF21A	SFMBT1	0.803	0.06
BAHCC1	MIDEAS	0.797
RERE	GSE1	0.793	0.096
CCDC71	BAHCC1	0.784
BAHCC1	PHF21A	0.749
HMG20B	MIDEAS	0.71	0.126	mutually_exclusive (Q92769)
RERE	DNTTIP1	0.71	0.07
HMG20B	DNTTIP1	0.71	0.09
MIER2	MIDEAS	0.709	0.042
RERE	PHF21A	0.658	0.23
RERE	MIDEAS	0.657	0.052
PHF21A	TRERF1	0.637		mutually_exclusive (Q13547)
PHF12	CCDC71	0.622	0.2
HMG20B	SFMBT1	0.618	0.094
RERE	MIER2	0.611	0.122
SFMBT1	GSE1	0.61	0.056
MIDEAS	PHF21A	0.61	0.04
GSE1	DNTTIP1	0.594	0.096
MIER2	PHF21A	0.563	0.064	mutually_exclusive (Q13547)
MIER2	HMG20B	0.563	0.08	mutually_exclusive (Q92769)
MIER2	GSE1	0.553	0.07
MIER2	DNTTIP1	0.55	0.068	mutually_exclusive (Q13547)
MIDEAS	GSE1	0.537	0.052
PHF21B	TRERF1	0.516
SFMBT1	HDAC2	0.506	0.08
SFMBT1	TRERF1	0.502
TRERF1	CASP8AP2	0.502
CCDC71	TRERF1	0.502		mutually_exclusive (Q13547)
PHF21B	CASP8AP2	0.497
PHF12	MIDEAS	0.488	0.088
PHF21A	DNTTIP1	0.443	0.072
PHF12	PHF21A	0.44	0.222
PHF12	DNTTIP1	0.412	0.134
SFMBT1	PHF21B	0.406
PHF21A	PWWP2A	0.396	0.118
MIDEAS	CASP8AP2	0.391	0.08
CCDC71	PWWP2A	0.359	0.134
HMG20B	PHF21B	0.336
MIDEAS	PHF21B	0.333
RERE	CASP8AP2	0.333	0.118
CCDC71	CASP8AP2	0.333	0.096
CCDC71	PHF21B	0.333
RERE	PHF21B	0.333
PHF21B	PWWP2A	0.333
CASP8AP2	PWWP2A	0.333	0.102
GSE1	CASP8AP2	0.306	0.06
CCDC71	MIDEAS	0.303	0.1	mutually_exclusive (Q13547)
CCDC71	SFMBT1	0.303	0.068
SFMBT1	PWWP2A	0.303	0.126
MIDEAS	SFMBT1	0.303	0.094
SFMBT1	CASP8AP2	0.265	0.188
HMG20B	CASP8AP2	0.265	0.084
PHF21A	PHF21B	0.265
PHF21A	CASP8AP2	0.262	0.08
GSE1	PHF21B	0.262
RERE	HDAC2	0.207	0.246
PHF12	CASP8AP2	0.2	0.104
CCDC71	DNTTIP1	0.172	0.068
MIER2	CASP8AP2	0.172	0.062
RERE	CCDC71	0.172	0.092
SFMBT1	DNTTIP1	0.172	0.084
MIER2	PWWP2A	0.172	0.098
CCDC71	MIER2	0.172	0.056	mutually_exclusive (Q13547)
PHF12	PHF21B	0.172
PHF21B	DNTTIP1	0.172
MIER2	SFMBT1	0.172	0.072
RERE	SFMBT1	0.172	0.11
MIER2	PHF21B	0.172
CASP8AP2	DNTTIP1	0.172	0.096
PHF12	SFMBT1	0.164	0.208
BAHCC1	PHF21B	0.164
CCDC71	PHF21A	0.164	0.096
CCDC71	HMG20B	0.164	0.134
PHF21B	HDAC2	0.159
PHF12	MIER2	0.145	0.132
MIER2	BAHCC1	0.143
BAHCC1	SFMBT1	0.143
CCDC71	GSE1	0.143	0.078
BAHCC1	CASP8AP2	0.143
CASP8AP2	HDAC2	0.131	0.178
CCDC71	HDAC2	0.121	0.404

Related Complexes

Genename	Complexes
PHF12	huMAP3_00411.1 huMAP3_01287.1 huMAP3_05699.1 huMAP3_06457.1 huMAP3_07709.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_09513.1 huMAP3_09515.1 huMAP3_10258.1 huMAP3_10311.1 huMAP3_13482.1 huMAP3_15128.1
PHF21A	huMAP3_01287.1 huMAP3_02683.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_08880.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_09692.1 huMAP3_10258.1 huMAP3_10311.1 huMAP3_15128.1
SFMBT1	huMAP3_01287.1 huMAP3_01666.1 huMAP3_06889.1 huMAP3_08605.1 huMAP3_08955.1 huMAP3_09232.1 huMAP3_10311.1 huMAP3_10505.1 huMAP3_15128.1
MIER2	huMAP3_00462.1 huMAP3_01287.1 huMAP3_02948.1 huMAP3_03637.1 huMAP3_07798.1 huMAP3_08057.1 huMAP3_09372.1 huMAP3_09707.1 huMAP3_10311.1 huMAP3_11539.1 huMAP3_15192.1
HDAC1	huMAP3_01287.1 huMAP3_06889.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_10311.1 huMAP3_15128.1
MIDEAS	huMAP3_01026.1 huMAP3_01287.1 huMAP3_05396.1 huMAP3_06334.1 huMAP3_06587.1 huMAP3_07709.1 huMAP3_08377.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_09319.1 huMAP3_09513.1 huMAP3_10311.1 huMAP3_10449.1 huMAP3_14722.1
CCDC71	huMAP3_00429.1 huMAP3_01287.1 huMAP3_06889.1 huMAP3_07299.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_10118.1 huMAP3_10311.1 huMAP3_13482.1 huMAP3_15128.1
GSE1	huMAP3_01287.1 huMAP3_05107.1 huMAP3_05699.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_08865.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_09692.1 huMAP3_10258.1 huMAP3_10311.1 huMAP3_15128.1
PHF21B	huMAP3_01287.1 huMAP3_01504.1 huMAP3_06860.1 huMAP3_06889.1 huMAP3_08605.1 huMAP3_09232.1 huMAP3_10122.1 huMAP3_10311.1 huMAP3_15128.1
TRERF1	huMAP3_01287.1 huMAP3_02407.1 huMAP3_05396.1 huMAP3_06334.1 huMAP3_07709.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_09513.1 huMAP3_10258.1 huMAP3_10311.1 huMAP3_15128.1
CASP8AP2	huMAP3_01287.1 huMAP3_06889.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_10311.1 huMAP3_14162.1 huMAP3_15009.1 huMAP3_15128.1
BAHCC1	huMAP3_00957.1 huMAP3_01287.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09311.1 huMAP3_10311.1 huMAP3_13482.1 huMAP3_15128.1
PWWP2A	huMAP3_01287.1 huMAP3_05396.1 huMAP3_05699.1 huMAP3_07709.1 huMAP3_08463.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_09499.1 huMAP3_09513.1 huMAP3_10258.1 huMAP3_10311.1 huMAP3_10472.1 huMAP3_15128.1
HDAC2	huMAP3_01287.1 huMAP3_03905.1 huMAP3_05579.1 huMAP3_08738.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09499.1 huMAP3_10311.1 huMAP3_10472.1 huMAP3_15128.1
DNTTIP1	huMAP3_01287.1 huMAP3_02407.1 huMAP3_05396.1 huMAP3_06334.1 huMAP3_07709.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_09513.1 huMAP3_10258.1 huMAP3_10311.1 huMAP3_11690.1
HMG20B	huMAP3_00955.1 huMAP3_01287.1 huMAP3_08165.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_10258.1 huMAP3_10311.1 huMAP3_15128.1
RERE	huMAP3_00047.1 huMAP3_01287.1 huMAP3_07585.1 huMAP3_08605.1 huMAP3_08776.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_09422.1 huMAP3_09513.1 huMAP3_10027.1 huMAP3_10258.1 huMAP3_10311.1 huMAP3_13482.1 huMAP3_15128.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_01287.1

Complex Portal: CPX-13515