hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01297.1
Complex Portal: CPX-21809
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| AP5S1 | AP-5 complex subunit sigma-1 (Adaptor-related protein complex 5 sigma subunit) (Sigma5) | 5 | UniProt NCBI |
| ZFYVE26 | Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin) | 5 | UniProt NCBI |
| AP5Z1 | AP-5 complex subunit zeta-1 (Adaptor-related protein complex 5 zeta subunit) (Zeta5) | 5 | UniProt NCBI |
| SPG11 | Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein) | 5 | UniProt NCBI |
| AP5M1 | AP-5 complex subunit mu-1 (Adaptor-related protein complex 5 subunit mu-1) (Mu5) (Mu-2-related death-inducing protein) (MuD) (Putative HIV-1 infection-related protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6602 | 1.57511210607e-16 | 1.0 | SPG11 AP5Z1 AP5S1 AP5M1 ZFYVE26 | AP5-SPG11-SPG15 complex |
| CORUM:6626 | 1.12081835382e-08 | 0.6 | AP5M1 AP5S1 AP5Z1 | AP5 adaptor complex |
| GO:0044599 | 3.84440695359e-06 | 0.6 | AP5M1 AP5S1 AP5Z1 | AP-5 adaptor complex |
| HP:0002839 | 3.02160410061e-05 | 0.6 | SPG11 ZFYVE26 AP5Z1 | Urinary bladder sphincter dysfunction |
| HP:0002064 | 0.000598637712806 | 0.6 | SPG11 ZFYVE26 AP5Z1 | Spastic gait |
| HP:0030890 | 0.000685212767946 | 0.6 | SPG11 ZFYVE26 AP5Z1 | Hyperintensity of cerebral white matter on MRI |
| HP:0001258 | 0.0022378814793 | 0.6 | SPG11 ZFYVE26 AP5Z1 | Spastic paraplegia |
| HP:0000020 | 0.00403288766139 | 0.6 | SPG11 ZFYVE26 AP5Z1 | Urinary incontinence |
| HP:0010550 | 0.00443745887352 | 0.6 | SPG11 ZFYVE26 AP5Z1 | Paraplegia |
| GO:0030119 | 0.00627040828674 | 0.6 | AP5M1 AP5S1 AP5Z1 | AP-type membrane coat adaptor complex |
| HP:0031064 | 0.00686727647703 | 0.6 | SPG11 ZFYVE26 AP5Z1 | Impaired continence |
| HP:0031058 | 0.00835766386712 | 0.6 | SPG11 ZFYVE26 AP5Z1 | Impairment of activities of daily living |
| GO:0005770 | 0.00858929342321 | 0.8 | AP5Z1 AP5S1 AP5M1 ZFYVE26 | late endosome |
| HP:0001152 | 0.0109419445801 | 0.4 | ZFYVE26 SPG11 | Saccadic smooth pursuit |
| HP:0010551 | 0.0149955818628 | 0.6 | SPG11 ZFYVE26 AP5Z1 | Paraplegia/paraparesis |
| HP:0006986 | 0.0161800923797 | 0.4 | ZFYVE26 SPG11 | Upper limb spasticity |
| HP:0007340 | 0.0172008238467 | 0.6 | SPG11 ZFYVE26 AP5Z1 | Lower limb muscle weakness |
| HP:0002061 | 0.0174583232226 | 0.6 | SPG11 ZFYVE26 AP5Z1 | Lower limb spasticity |
| HP:0003676 | 0.0285128446266 | 0.6 | SPG11 ZFYVE26 AP5Z1 | Progressive |
| HP:0002071 | 0.0397439725678 | 0.6 | SPG11 ZFYVE26 AP5Z1 | Abnormality of extrapyramidal motor function |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| AP5S1 | ZFYVE26 | 0.999 | 0.148 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| AP5Z1 | SPG11 | 0.999 | 0.15 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| AP5S1 | AP5Z1 | 0.998 | 0.334 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| AP5S1 | SPG11 | 0.998 | 0.112 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SPG11 | AP5M1 | 0.998 | 0.202 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| AP5S1 | AP5M1 | 0.998 | 0.232 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ZFYVE26 | AP5M1 | 0.811 | 0.174 | bioplex3_WMM WMM_only | |
| AP5Z1 | AP5M1 | 0.804 | 0.102 | bioplex3_WMM WMM_only | |
| ZFYVE26 | AP5Z1 | 0.727 | 0.214 | bioplex3_WMM WMM_only | |
| ZFYVE26 | SPG11 | 0.722 | 0.198 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| AP5S1 | huMAP3_01297.1 huMAP3_09124.1 huMAP3_14796.1 |
| ZFYVE26 | huMAP3_01297.1 huMAP3_09124.1 huMAP3_14796.1 |
| AP5Z1 | huMAP3_01297.1 huMAP3_09124.1 huMAP3_14796.1 |
| SPG11 | huMAP3_01297.1 huMAP3_09124.1 huMAP3_14796.1 |
| AP5M1 | huMAP3_01297.1 huMAP3_09124.1 huMAP3_12854.1 huMAP3_14796.1 |