hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01350.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EDRF1 | Erythroid differentiation-related factor 1 | 5 | UniProt NCBI |
| HSP90AB1 | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) | 5 | UniProt NCBI |
| HSP90AA1 | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | 5 | UniProt NCBI |
| UNC45B | Protein unc-45 homolog B (Unc-45B) (SMUNC45) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2112 | 1.53774525569e-05 | 0.5 | HSP90AB1 HSP90AA1 | CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex |
| CORUM:5234 | 5.12488211613e-05 | 0.5 | HSP90AB1 HSP90AA1 | IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex |
| CORUM:5269 | 7.68662167609e-05 | 0.5 | HSP90AB1 HSP90AA1 | TNF-alpha/NF-kappa B signaling complex 8 |
| CORUM:5268 | 0.000143457417375 | 0.5 | HSP90AB1 HSP90AA1 | TNF-alpha/NF-kappa B signaling complex 7 |
| CORUM:5212 | 0.000143457417375 | 0.5 | HSP90AB1 HSP90AA1 | Kinase maturation complex 2 |
| REAC:R-HSA-5336415 | 0.000153732433522 | 0.5 | HSP90AB1 HSP90AA1 | Uptake and function of diphtheria toxin |
| CORUM:5286 | 0.000230514481314 | 0.5 | HSP90AB1 HSP90AA1 | TNF-alpha/NF-kappa B signaling complex 10 |
| CORUM:5266 | 0.00039944903428 | 0.5 | HSP90AB1 HSP90AA1 | TNF-alpha/NF-kappa B signaling complex 6 |
| CORUM:5199 | 0.000614368694056 | 0.5 | HSP90AB1 HSP90AA1 | Kinase maturation complex 1 |
| REAC:R-HSA-3371511 | 0.000676052383047 | 0.5 | HSP90AB1 HSP90AA1 | HSF1 activation |
| REAC:R-HSA-3371568 | 0.000798898068561 | 0.5 | HSP90AB1 HSP90AA1 | Attenuation phase |
| REAC:R-HSA-399954 | 0.00107524337392 | 0.5 | HSP90AB1 HSP90AA1 | Sema3A PAK dependent Axon repulsion |
| REAC:R-HSA-5339562 | 0.00175047124894 | 0.5 | HSP90AB1 HSP90AA1 | Uptake and actions of bacterial toxins |
| REAC:R-HSA-9613829 | 0.00214930898727 | 0.5 | HSP90AB1 HSP90AA1 | Chaperone Mediated Autophagy |
| REAC:R-HSA-3371571 | 0.00258893271292 | 0.5 | HSP90AB1 HSP90AA1 | HSF1-dependent transactivation |
| REAC:R-HSA-9013418 | 0.00258893271292 | 0.5 | HSP90AB1 HSP90AA1 | RHOBTB2 GTPase cycle |
| GO:1902949 | 0.0028092043205 | 0.5 | HSP90AB1 HSP90AA1 | positive regulation of tau-protein kinase activity |
| KEGG:04612 | 0.00456536626645 | 0.5 | HSP90AB1 HSP90AA1 | Antigen processing and presentation |
| REAC:R-HSA-9706574 | 0.006081926491 | 0.5 | HSP90AB1 HSP90AA1 | RHOBTB GTPase Cycle |
| KEGG:04657 | 0.00728891894502 | 0.5 | HSP90AB1 HSP90AA1 | IL-17 signaling pathway |
| KEGG:04914 | 0.00826911293642 | 0.5 | HSP90AB1 HSP90AA1 | Progesterone-mediated oocyte maturation |
| KEGG:04659 | 0.00996493530849 | 0.5 | HSP90AB1 HSP90AA1 | Th17 cell differentiation |
| KEGG:05215 | 0.00996493530849 | 0.5 | HSP90AB1 HSP90AA1 | Prostate cancer |
| KEGG:04915 | 0.0104133784038 | 0.5 | HSP90AB1 HSP90AA1 | Estrogen signaling pathway |
| REAC:R-HSA-3371497 | 0.0135329645116 | 0.5 | HSP90AB1 HSP90AA1 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand |
| REAC:R-HSA-2029482 | 0.0157112703152 | 0.5 | HSP90AB1 HSP90AA1 | Regulation of actin dynamics for phagocytic cup formation |
| WP:WP2884 | 0.015715675352 | 0.5 | HSP90AB1 HSP90AA1 | NRF2 pathway |
| KEGG:05418 | 0.0168426929383 | 0.5 | HSP90AB1 HSP90AA1 | Fluid shear stress and atherosclerosis |
| REAC:R-HSA-9824439 | 0.0174510452107 | 0.5 | HSP90AB1 HSP90AA1 | Bacterial Infection Pathways |
| REAC:R-HSA-373755 | 0.0174510452107 | 0.5 | HSP90AB1 HSP90AA1 | Semaphorin interactions |
| KEGG:04217 | 0.0230797254414 | 0.5 | HSP90AB1 HSP90AA1 | Necroptosis |
| CORUM:5716 | 0.0249718442456 | 0.25 | HSP90AA1 | NOS3-HSP90 complex, VEGF induced |
| KEGG:04621 | 0.02620193588 | 0.5 | HSP90AB1 HSP90AA1 | NOD-like receptor signaling pathway |
| GO:0030911 | 0.0280843539964 | 0.5 | HSP90AB1 HSP90AA1 | TPR domain binding |
| GO:0044294 | 0.0280843539964 | 0.5 | HSP90AB1 HSP90AA1 | dendritic growth cone |
| GO:1902947 | 0.0280843539964 | 0.5 | HSP90AB1 HSP90AA1 | regulation of tau-protein kinase activity |
| REAC:R-HSA-168928 | 0.0282617295192 | 0.5 | HSP90AB1 HSP90AA1 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| REAC:R-HSA-8852276 | 0.0290229039331 | 0.5 | HSP90AB1 HSP90AA1 | The role of GTSE1 in G2/M progression after G2 checkpoint |
| KEGG:04141 | 0.0298999303213 | 0.5 | HSP90AB1 HSP90AA1 | Protein processing in endoplasmic reticulum |
| REAC:R-HSA-2029480 | 0.0305753786405 | 0.5 | HSP90AB1 HSP90AA1 | Fcgamma receptor (FCGR) dependent phagocytosis |
| KEGG:05207 | 0.0326315237827 | 0.5 | HSP90AB1 HSP90AA1 | Chemical carcinogenesis - receptor activation |
| REAC:R-HSA-9679191 | 0.0363250695065 | 0.5 | HSP90AB1 HSP90AA1 | Potential therapeutics for SARS |
| REAC:R-HSA-3371556 | 0.0363250695065 | 0.5 | HSP90AB1 HSP90AA1 | Cellular response to heat stress |
| KEGG:05417 | 0.0397541089323 | 0.5 | HSP90AB1 HSP90AA1 | Lipid and atherosclerosis |
| GO:1905323 | 0.042122686785 | 0.5 | HSP90AB1 HSP90AA1 | telomerase holoenzyme complex assembly |
| GO:0030235 | 0.042122686785 | 0.5 | HSP90AB1 HSP90AA1 | nitric-oxide synthase regulator activity |
| GO:0044292 | 0.042122686785 | 0.5 | HSP90AB1 HSP90AA1 | dendrite terminus |
| CORUM:4158 | 0.049938562206 | 0.25 | HSP90AA1 | HSP90-FKBP38-CAM-Ca(2+) complex |
| CORUM:5718 | 0.049938562206 | 0.25 | HSP90AA1 | NOS3-HSP90-AKT complex, VEGF induced |
| CORUM:5849 | 0.049938562206 | 0.25 | HSP90AB1 | HSP90-CDC37-LRRK2 complex |
| CORUM:5980 | 0.049938562206 | 0.25 | HSP90AB1 | LRRK2-CHIP-HSP90 complex |
| CORUM:6399 | 0.049938562206 | 0.25 | HSP90AA1 | DNAJC7-HSPA8-HSP90AA1 complex |
| CORUM:6402 | 0.049938562206 | 0.25 | HSP90AA1 | NMNAT2-HSP90 complex |
| CORUM:6591 | 0.049938562206 | 0.25 | HSP90AA1 | Hsp90-p23 complex |
| CORUM:6706 | 0.049938562206 | 0.25 | HSP90AB1 | CAPN1-HSP90AB1 complex |
| CORUM:7284 | 0.049938562206 | 0.25 | HSP90AA1 | GSK3B-HSP90AA1-PKM2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| HSP90AB1 | HSP90AA1 | 1.0 | 0.954 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt hein () Malo bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| EDRF1 | HSP90AB1 | 0.995 | 0.32305 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
| EDRF1 | HSP90AA1 | 0.983 | 0.474 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only |
| HSP90AB1 | UNC45B | 0.963 | 0.144 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| HSP90AA1 | UNC45B | 0.952 | 0.207431818182 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes