hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01372.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NDUFB6 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (Complex I-B17) (CI-B17) (NADH-ubiquinone oxidoreductase B17 subunit) | 5 | UniProt NCBI |
| NDUFA12 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (13 kDa differentiation-associated protein) (Complex I-B17.2) (CI-B17.2) (CIB17.2) (NADH-ubiquinone oxidoreductase subunit B17.2) | 5 | UniProt NCBI |
| NDUFA8 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (Complex I-19kD) (CI-19kD) (Complex I-PGIV) (CI-PGIV) (NADH-ubiquinone oxidoreductase 19 kDa subunit) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4324 | 2.03363651423e-06 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | Mitochondrial complex I assembly model OXPHOS system |
| CORUM:178 | 2.88617378814e-06 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | Respiratory chain complex I (holoenzyme), mitochondrial |
| WP:WP111 | 1.17898981996e-05 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | Electron transport chain OXPHOS system in mitochondria |
| REAC:R-HSA-6799198 | 1.365277865e-05 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | Complex I biogenesis |
| KEGG:04723 | 1.43040725693e-05 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | Retrograde endocannabinoid signaling |
| KEGG:00190 | 1.54230874605e-05 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | Oxidative phosphorylation |
| KEGG:04932 | 2.28801742777e-05 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | Non-alcoholic fatty liver disease |
| WP:WP4396 | 3.24963255001e-05 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | Nonalcoholic fatty liver disease |
| KEGG:05415 | 5.16258651055e-05 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | Diabetic cardiomyopathy |
| KEGG:05208 | 7.07004693439e-05 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | Chemical carcinogenesis - reactive oxygen species |
| REAC:R-HSA-611105 | 7.31860792369e-05 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | Respiratory electron transport |
| KEGG:04714 | 7.39136996301e-05 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | Thermogenesis |
| KEGG:05012 | 0.00011589966492 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | Parkinson disease |
| KEGG:05020 | 0.000126475690353 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | Prion disease |
| REAC:R-HSA-163200 | 0.000134372084608 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| KEGG:05016 | 0.000171368189864 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | Huntington disease |
| KEGG:05014 | 0.00029339200738 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | Amyotrophic lateral sclerosis |
| KEGG:05010 | 0.000339187774081 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | Alzheimer disease |
| REAC:R-HSA-1428517 | 0.000368729542429 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | The citric acid (TCA) cycle and respiratory electron transport |
| KEGG:05022 | 0.000613327564103 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | Pathways of neurodegeneration - multiple diseases |
| GO:0008137 | 0.000949666005835 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | NADH dehydrogenase (ubiquinone) activity |
| GO:0050136 | 0.00102463963787 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | NADH dehydrogenase (quinone) activity |
| GO:0003954 | 0.00110345807156 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | NADH dehydrogenase activity |
| GO:0003955 | 0.00127301382402 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | NAD(P)H dehydrogenase (quinone) activity |
| HPA:0471473 | 0.00176667046737 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 2; lymphocytes[High] |
| GO:0005747 | 0.00177091563679 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | mitochondrial respiratory chain complex I |
| GO:0030964 | 0.00177091563679 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | NADH dehydrogenase complex |
| GO:0045271 | 0.00177091563679 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | respiratory chain complex I |
| WP:WP623 | 0.00193308448658 | 0.666666666667 | NDUFA8 NDUFB6 | Oxidative phosphorylation |
| GO:0016655 | 0.00266444753864 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
| GO:0015453 | 0.00296587998745 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | oxidoreduction-driven active transmembrane transporter activity |
| GO:0042776 | 0.00381702295119 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | proton motive force-driven mitochondrial ATP synthesis |
| HPA:0460202 | 0.00387515227421 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 1; endothelial cells[>=Medium] |
| HPA:0470202 | 0.00474247809279 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 2; endothelial cells[>=Medium] |
| HPA:0461392 | 0.00491069279856 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 1; cells in basal layer[>=Medium] |
| HPA:0471472 | 0.00500857768833 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 2; lymphocytes[>=Medium] |
| HPA:0470672 | 0.00503325048482 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 2; melanocytes[>=Medium] |
| GO:0015986 | 0.00526161104852 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | proton motive force-driven ATP synthesis |
| HPA:0471462 | 0.0053614064234 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 2; langerhans cells[>=Medium] |
| HPA:0471412 | 0.00581164540589 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 2; cells in spinous layer[>=Medium] |
| HPA:0570783 | 0.0059487071562 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | testis; preleptotene spermatocytes[High] |
| GO:0016651 | 0.00623088554274 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | oxidoreductase activity, acting on NAD(P)H |
| HPA:0461442 | 0.0062577927992 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 1; fibrohistiocytic cells[>=Medium] |
| HPA:0470181 | 0.00660698711107 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 2; cells in granular layer[>=Low] |
| HPA:0461461 | 0.00706144293007 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 1; langerhans cells[>=Low] |
| HPA:0470671 | 0.00731212240844 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 2; melanocytes[>=Low] |
| GO:0098803 | 0.00760107672828 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | respiratory chain complex |
| HPA:0471392 | 0.00799822858561 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 2; cells in basal layer[>=Medium] |
| HPA:0461411 | 0.0084089015935 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 1; cells in spinous layer[>=Low] |
| GO:0006754 | 0.00851239083773 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | ATP biosynthetic process |
| GO:0042775 | 0.00851239083773 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | mitochondrial ATP synthesis coupled electron transport |
| GO:0042773 | 0.00851239083773 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | ATP synthesis coupled electron transport |
| HPA:0471461 | 0.00905089926356 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 2; langerhans cells[>=Low] |
| GO:0009206 | 0.00915870199393 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | purine ribonucleoside triphosphate biosynthetic process |
| GO:0009145 | 0.00915870199393 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | purine nucleoside triphosphate biosynthetic process |
| GO:0070469 | 0.00949377645712 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | respirasome |
| GO:0005746 | 0.00949377645712 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | mitochondrial respirasome |
| HPA:0471471 | 0.00957222629825 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 2; lymphocytes[>=Low] |
| HPA:0471442 | 0.0105118333285 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 2; fibrohistiocytic cells[>=Medium] |
| GO:0009201 | 0.0109157763448 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | ribonucleoside triphosphate biosynthetic process |
| HPA:0460201 | 0.0109208095397 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 1; endothelial cells[>=Low] |
| GO:0022904 | 0.0116771431902 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | respiratory electron transport chain |
| HPA:0570763 | 0.0119453326684 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | testis; pachytene spermatocytes[High] |
| GO:0009142 | 0.0120707547584 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | nucleoside triphosphate biosynthetic process |
| HPA:0471411 | 0.012211103258 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 2; cells in spinous layer[>=Low] |
| HPA:0461441 | 0.0127085332088 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 1; fibrohistiocytic cells[>=Low] |
| HPA:0470201 | 0.0128004018578 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 2; endothelial cells[>=Low] |
| HPA:0461391 | 0.0128927121824 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 1; cells in basal layer[>=Low] |
| GO:0009055 | 0.0141719388563 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | electron transfer activity |
| GO:0022900 | 0.0150763323228 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | electron transport chain |
| HPA:0471391 | 0.0165736132678 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 2; cells in basal layer[>=Low] |
| HPA:0460673 | 0.0169594584426 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 1; melanocytes[High] |
| KEGG:01100 | 0.0189521995452 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | Metabolic pathways |
| HPA:0471441 | 0.0193402202577 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | skin 2; fibrohistiocytic cells[>=Low] |
| GO:1990204 | 0.0219076797621 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | oxidoreductase complex |
| HPA:0080133 | 0.0230059154439 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | caudate; neuronal cells[High] |
| GO:0006119 | 0.025655976884 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | oxidative phosphorylation |
| HPA:0241103 | 0.0256905205202 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | heart muscle; cardiomyocytes[High] |
| GO:0015399 | 0.0328130751425 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | primary active transmembrane transporter activity |
| HPA:0250133 | 0.0339994352931 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | hippocampus; neuronal cells[High] |
| HPA:0050053 | 0.0436171192214 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | breast; glandular cells[High] |
| HPA:0570782 | 0.0440355061936 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | testis; preleptotene spermatocytes[>=Medium] |
| HPA:0570813 | 0.0443510461782 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | testis; spermatogonia cells[High] |
| HP:0011923 | 0.0493566712329 | 0.666666666667 | NDUFA12 NDUFA8 | Decreased activity of mitochondrial complex I |
| GO:0098800 | 0.0498541011049 | 1.0 | NDUFA12 NDUFB6 NDUFA8 | inner mitochondrial membrane protein complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NDUFA12 | NDUFA8 | 0.998 | 0.844 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| NDUFB6 | NDUFA8 | 0.994 | 0.93 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| NDUFB6 | NDUFA12 | 0.983 | 0.574 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes