hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_01386.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EYA2 | Eyes absent homolog 2 (EC 3.1.3.48) | 5 | UniProt NCBI |
| EYA3 | Eyes absent homolog 3 (EC 3.1.3.48) | 5 | UniProt NCBI |
| SIX2 | Homeobox protein SIX2 (Sine oculis homeobox homolog 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0140789 | 0.00421361424067 | 0.666666666667 | EYA2 EYA3 | histone phosphatase activity |
| GO:0140793 | 0.00421361424067 | 0.666666666667 | EYA2 EYA3 | histone H2AXY142 phosphatase activity |
| GO:0007501 | 0.0140440992017 | 0.666666666667 | SIX2 EYA2 | mesodermal cell fate specification |
| REAC:R-HSA-5693565 | 0.0168905285744 | 0.666666666667 | EYA2 EYA3 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| REAC:R-HSA-5693606 | 0.017372320015 | 0.666666666667 | EYA2 EYA3 | DNA Double Strand Break Response |
| GO:0001710 | 0.0210651876021 | 0.666666666667 | SIX2 EYA2 | mesodermal cell fate commitment |
| CORUM:7364 | 0.0499402709677 | 0.333333333333 | SIX2 | EYA1-SIX2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| EYA2 | SIX2 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| EYA3 | SIX2 | 0.973 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| EYA3 | EYA2 | 0.333 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes