hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_01388.1
Complex Portal: CPX-21325
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| AP4S1 | AP-4 complex subunit sigma-1 (AP-4 adaptor complex subunit sigma-1) (Adaptor-related protein complex 4 subunit sigma-1) (Sigma-1 subunit of AP-4) (Sigma-4-adaptin) (Sigma4-adaptin) | 5 | UniProt NCBI |
| MYH7B | Myosin-7B (Antigen MLAA-21) (Myosin cardiac muscle beta chain) (Myosin heavy chain 7B, cardiac muscle beta isoform) (Slow A MYH14) | 5 | UniProt NCBI |
| AP4M1 | AP-4 complex subunit mu-1 (AP-4 adaptor complex mu subunit) (Adaptor-related protein complex 4 subunit mu-1) (Mu subunit of AP-4) (Mu-adaptin-related protein 2) (mu-ARP2) (Mu4-adaptin) (mu4) | 5 | UniProt NCBI |
| AP4E1 | AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin) | 5 | UniProt NCBI |
| AP4B1 | AP-4 complex subunit beta-1 (AP-4 adaptor complex subunit beta) (Adaptor-related protein complex 4 subunit beta-1) (Beta subunit of AP-4) (Beta4-adaptin) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:67 | 4.80157500167e-14 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | AP4 adaptor complex |
| GO:0030124 | 2.63126310092e-11 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | AP-4 adaptor complex |
| HP:5200020 | 6.57815775229e-11 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal interest in others |
| HP:0100962 | 6.57815775229e-11 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Shyness |
| HP:0008807 | 1.51767496714e-09 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Acetabular dysplasia |
| HP:0002464 | 1.8747749594e-09 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Spastic dysarthria |
| HP:0010803 | 2.29139161705e-09 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Everted upper lip vermilion |
| REAC:R-HSA-432720 | 3.92960898137e-09 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Lysosome Vesicle Biogenesis |
| HP:0007020 | 6.41370380848e-09 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Progressive spastic paraplegia |
| HP:0002816 | 1.28180102487e-08 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Genu recurvatum |
| HP:0025502 | 2.06883061309e-08 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Overweight |
| HP:0002761 | 2.06883061309e-08 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Generalized joint hypermobility |
| HP:0010500 | 2.31222244993e-08 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Hyperextensibility of the knee |
| HP:0000297 | 3.86576403909e-08 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Facial hypotonia |
| REAC:R-HSA-199992 | 8.80508022231e-08 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | trans-Golgi Network Vesicle Budding |
| KEGG:04142 | 2.13288072552e-07 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Lysosome |
| GO:0031904 | 3.93373833587e-07 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | endosome lumen |
| HP:0003170 | 4.01886282964e-07 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal acetabulum morphology |
| HP:0034670 | 4.23907449154e-07 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal knee physiology |
| HP:0002307 | 1.08534590983e-06 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Drooling |
| HP:0000646 | 1.17917424604e-06 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Amblyopia |
| HP:0001258 | 1.33116070144e-06 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Spastic paraplegia |
| GO:0030119 | 1.37772935964e-06 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | AP-type membrane coat adaptor complex |
| HP:0003781 | 1.49738604915e-06 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Excessive salivation |
| HP:0002515 | 1.61653841324e-06 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Waddling gait |
| HP:0010550 | 3.34170413816e-06 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Paraplegia |
| HP:0002518 | 3.34170413816e-06 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal periventricular white matter morphology |
| HP:0012433 | 4.94213702851e-06 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal social behavior |
| HP:0000341 | 6.69532727168e-06 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Narrow forehead |
| HP:0012472 | 7.2453802931e-06 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Eclabion |
| HP:0100755 | 1.07724569167e-05 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormality of salivation |
| HP:0000414 | 1.10289439862e-05 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Bulbous nose |
| HP:0002465 | 1.10289439862e-05 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Poor speech |
| HP:0010551 | 1.71879368278e-05 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Paraplegia/paraparesis |
| HP:0000154 | 1.79212122168e-05 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Wide mouth |
| HP:0002061 | 2.10913435915e-05 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Lower limb spasticity |
| HP:0000280 | 2.37316814177e-05 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Coarse facial features |
| HP:0002352 | 2.51411488222e-05 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Leukoencephalopathy |
| HP:0000322 | 3.43498946312e-05 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Short philtrum |
| HP:0000733 | 4.29414682824e-05 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal repetitive mannerisms |
| HP:0031432 | 4.29414682824e-05 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Restricted or repetitive behaviors or interests |
| HP:0031828 | 5.475302666e-05 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal superficial reflex |
| HP:0003487 | 5.475302666e-05 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Babinski sign |
| HP:0002355 | 5.82773357586e-05 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Difficulty walking |
| GO:0030117 | 5.85691538001e-05 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | membrane coat |
| GO:0048475 | 5.85691538001e-05 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | coated membrane |
| GO:0032588 | 7.03249795192e-05 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | trans-Golgi network membrane |
| HP:0000301 | 7.7394767168e-05 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormality of facial musculature |
| HP:0031815 | 7.7394767168e-05 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal oral physiology |
| HP:0002120 | 0.000110738016969 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Cerebral cortical atrophy |
| HP:0001763 | 0.000115181864812 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Pes planus |
| HP:0010864 | 0.000134307662699 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Intellectual disability, severe |
| HP:0001384 | 0.00014294221678 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal hip joint morphology |
| HP:0000436 | 0.000153845721562 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal nasal tip morphology |
| HP:0034353 | 0.000181706938615 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Appendicular spasticity |
| HP:0002815 | 0.000190319808582 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormality of the knee |
| HP:0001762 | 0.000192520037583 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Talipes equinovarus |
| HP:0011337 | 0.000240666543667 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormality of mouth size |
| HP:0007256 | 0.000276467736521 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal pyramidal sign |
| HP:0001272 | 0.000291249019879 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Cerebellar atrophy |
| HP:0011339 | 0.000319339585968 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormality of upper lip vermillion |
| HP:0004324 | 0.000342555215922 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Increased body weight |
| HP:0001883 | 0.000349414735264 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Talipes |
| HP:0005656 | 0.000363442310534 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Positional foot deformity |
| HP:0002079 | 0.000374236974998 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Hypoplasia of the corpus callosum |
| HP:0004302 | 0.000423817124783 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Functional motor deficit |
| REAC:R-HSA-199991 | 0.000426838992032 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Membrane Trafficking |
| HP:0011799 | 0.000460918752077 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormality of facial soft tissue |
| HP:0010549 | 0.000478167775244 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Weakness due to upper motor neuron dysfunction |
| REAC:R-HSA-5653656 | 0.000530772712934 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Vesicle-mediated transport |
| HP:0001332 | 0.000552049008335 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Dystonia |
| HP:0001382 | 0.000672853608305 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Joint hypermobility |
| HP:0003272 | 0.000689959297799 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal hip bone morphology |
| HP:0007663 | 0.000743237254027 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Reduced visual acuity |
| HP:0001260 | 0.000950630911942 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Dysarthria |
| HP:0002644 | 0.00108130666724 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal pelvic girdle bone morphology |
| HP:0002059 | 0.00158690249067 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Cerebral atrophy |
| HP:0007369 | 0.00181306555755 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Atrophy/Degeneration affecting the cerebrum |
| HP:0100491 | 0.00186105162863 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormality of lower limb joint |
| HP:0000288 | 0.00207569932807 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormality of the philtrum |
| HP:0100021 | 0.00230848648861 | 0.75 | AP4E1 AP4S1 AP4M1 | Cerebral palsy |
| GO:0005802 | 0.00236438803028 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | trans-Golgi network |
| HP:0000218 | 0.00274984731609 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | High palate |
| HP:0007370 | 0.00274984731609 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Aplasia/Hypoplasia of the corpus callosum |
| HP:0012444 | 0.00294990850486 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Brain atrophy |
| HP:0002538 | 0.00298428444273 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal cerebral cortex morphology |
| HP:0001319 | 0.00333681790295 | 0.75 | AP4B1 AP4M1 AP4E1 | Neonatal hypotonia |
| HP:0001347 | 0.00336365220097 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Hyperreflexia |
| GO:0006605 | 0.0038541674925 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | protein targeting |
| HP:0033725 | 0.00418502298343 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Thin corpus callosum |
| HP:0007367 | 0.00441195701352 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Atrophy/Degeneration affecting the central nervous system |
| GO:0098791 | 0.00452739089194 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Golgi apparatus subcompartment |
| HP:0010938 | 0.00489338469633 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal external nose morphology |
| HP:0001257 | 0.00535941513557 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Spasticity |
| HP:0001273 | 0.00568807850398 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal corpus callosum morphology |
| HP:0000177 | 0.00629933350195 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal upper lip morphology |
| HP:0001317 | 0.00795240650999 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal cerebellum morphology |
| HP:0011283 | 0.00809740415548 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal metencephalon morphology |
| HP:0011282 | 0.00809740415548 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal hindbrain morphology |
| HP:5200241 | 0.0094113912304 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Recurrent maladaptive behavior |
| HP:0001999 | 0.0103428480905 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal facial shape |
| HP:0000505 | 0.0106981262558 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Visual impairment |
| HP:0002500 | 0.0112014831127 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal cerebral white matter morphology |
| HP:0031936 | 0.011350921992 | 0.75 | AP4B1 AP4S1 AP4E1 | Delayed ability to walk |
| HP:0000486 | 0.0119162519121 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Strabismus |
| HP:0000174 | 0.0121619400741 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal palate morphology |
| HP:0001276 | 0.0130257834758 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Hypertonia |
| HP:0000549 | 0.0136087412238 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal conjugate eye movement |
| HP:0001367 | 0.0137168003098 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal joint morphology |
| HP:0001288 | 0.0140448412414 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Gait disturbance |
| REAC:R-HSA-432722 | 0.0146019089592 | 0.5 | AP4E1 AP4B1 | Golgi Associated Vesicle Biogenesis |
| HP:0000290 | 0.0146046080279 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormality of the forehead |
| HP:0010993 | 0.0151809428209 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal cerebral subcortex morphology |
| HP:0002493 | 0.0156541570676 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Upper motor neuron dysfunction |
| HP:0031826 | 0.0165711549475 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal reflex |
| HP:0000159 | 0.016885589704 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal lip morphology |
| HP:0000504 | 0.0208694367619 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormality of vision |
| HP:0011729 | 0.0218513629119 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormality of joint mobility |
| HP:0034430 | 0.0218513629119 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal joint physiology |
| HP:0002540 | 0.0219389426652 | 0.75 | AP4B1 AP4S1 AP4E1 | Inability to walk |
| HP:0000252 | 0.0246674560744 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Microcephaly |
| HP:0040195 | 0.025606252379 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Decreased head circumference |
| HP:0004322 | 0.0263940803883 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Short stature |
| HP:0005105 | 0.0305105137394 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal nasal morphology |
| HP:0000002 | 0.0361997133303 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormality of body height |
| HP:0001760 | 0.0361997133303 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal foot morphology |
| HP:0002194 | 0.0481822683014 | 0.75 | AP4B1 AP4S1 AP4E1 | Delayed gross motor development |
| HP:0011843 | 0.0482339333137 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Abnormal musculoskeletal physiology |
| HP:0007364 | 0.0483732370923 | 1.0 | AP4B1 AP4E1 AP4S1 AP4M1 | Aplasia/Hypoplasia of the cerebrum |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| AP4S1 | AP4B1 | 1.0 | 0.172 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| AP4E1 | AP4B1 | 1.0 | 0.284 |
mutually_exclusive (Q9Y587)
|
hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| AP4M1 | AP4E1 | 1.0 | 0.17 |
mutually_exclusive (Q9Y587)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| AP4M1 | AP4B1 | 0.999 | 0.18 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| AP4S1 | AP4M1 | 0.999 | 0.112 |
mutually_exclusive (Q9Y6B7)
structurally_consistent (dimer) |
hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM |
| AP4S1 | AP4E1 | 0.999 | 0.166342857143 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| MYH7B | AP4B1 | 0.984 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| AP4S1 | MYH7B | 0.356 | bioplex3_WMM WMM_only | ||
| MYH7B | AP4E1 | 0.356 | bioplex3_WMM WMM_only | ||
| MYH7B | AP4M1 | 0.343 | bioplex3_WMM WMM_only |
Related Complexes