hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_01393.1
Complex Portal: CPX-20630
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MTMR9 | Myotubularin-related protein 9 (Inactive phosphatidylinositol 3-phosphatase 9) | 5 | UniProt NCBI |
| MTMR7 | Myotubularin-related protein 7 (Inositol 1,3-bisphosphate phosphatase) (EC 3.1.3.-) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64) | 5 | UniProt NCBI |
| MTMR6 | Myotubularin-related protein 6 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4971 | 8.89885541579e-07 | 1.0 | MTMR9 MTMR7 MTMR6 | Phosphoinositides metabolism |
| WP:WP5346 | 8.89885541579e-07 | 1.0 | MTMR9 MTMR7 MTMR6 | 8p23 1 copy number variation syndrome |
| REAC:R-HSA-1483255 | 2.78281516981e-05 | 1.0 | MTMR9 MTMR7 MTMR6 | PI Metabolism |
| GO:0046856 | 0.000127839654632 | 1.0 | MTMR9 MTMR7 MTMR6 | phosphatidylinositol dephosphorylation |
| REAC:R-HSA-1660517 | 0.000374861161166 | 0.666666666667 | MTMR9 MTMR7 | Synthesis of PIPs at the late endosome membrane |
| REAC:R-HSA-1483257 | 0.000416769032473 | 1.0 | MTMR9 MTMR7 MTMR6 | Phospholipid metabolism |
| REAC:R-HSA-1855183 | 0.000449812862905 | 0.666666666667 | MTMR9 MTMR7 | Synthesis of IP2, IP, and Ins in the cytosol |
| GO:0046839 | 0.000476755403739 | 1.0 | MTMR9 MTMR7 MTMR6 | phospholipid dephosphorylation |
| KEGG:00562 | 0.00158324752529 | 0.666666666667 | MTMR6 MTMR7 | Inositol phosphate metabolism |
| KEGG:04070 | 0.00271491421694 | 0.666666666667 | MTMR6 MTMR7 | Phosphatidylinositol signaling system |
| REAC:R-HSA-1483249 | 0.00504394814871 | 0.666666666667 | MTMR9 MTMR7 | Inositol phosphate metabolism |
| REAC:R-HSA-1660499 | 0.00735562020533 | 0.666666666667 | MTMR9 MTMR6 | Synthesis of PIPs at the plasma membrane |
| REAC:R-HSA-556833 | 0.0177385429708 | 1.0 | MTMR9 MTMR7 MTMR6 | Metabolism of lipids |
| GO:0046488 | 0.030542143052 | 1.0 | MTMR9 MTMR7 MTMR6 | phosphatidylinositol metabolic process |
| GO:0030258 | 0.0402954436201 | 1.0 | MTMR9 MTMR7 MTMR6 | lipid modification |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MTMR9 | MTMR6 | 1.0 | 0.582 |
mutually_exclusive (Q9Y216)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| MTMR9 | MTMR7 | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MTMR7 | MTMR6 | 0.999 |
mutually_exclusive (Q96QG7)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes
| Genename | Complexes |
|---|---|
| MTMR9 | huMAP3_01393.1 huMAP3_10161.1 huMAP3_11523.1 |
| MTMR7 | huMAP3_01393.1 huMAP3_10161.1 huMAP3_11523.1 |
| MTMR6 | huMAP3_01393.1 huMAP3_10161.1 huMAP3_11523.1 |