hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_01396.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PPP1R3B | Protein phosphatase 1 regulatory subunit 3B (Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL) (Protein phosphatase 1 regulatory subunit 4) (PP1 subunit R4) (Protein phosphatase 1 subunit GL) (PTG) | 4 | UniProt NCBI |
| GYG2 | Glycogenin-2 (GN-2) (GN2) (EC 2.4.1.186) | 5 | UniProt NCBI |
| PPP1R3F | Protein phosphatase 1 regulatory subunit 3F (R3F) | 5 | UniProt NCBI |
| PPP1R3C | Protein phosphatase 1 regulatory subunit 3C (Protein phosphatase 1 regulatory subunit 5) (PP1 subunit R5) (Protein targeting to glycogen) (PTG) | 5 | UniProt NCBI |
| STBD1 | Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1) | 5 | UniProt NCBI |
| GYS2 | Glycogen [starch] synthase, liver (EC 2.4.1.11) (Glycogen synthase 2) | 5 | UniProt NCBI |
| PYGB | Glycogen phosphorylase, brain form (EC 2.4.1.1) | 5 | UniProt NCBI |
| PYGL | Glycogen phosphorylase, liver form (EC 2.4.1.1) | 5 | UniProt NCBI |
| AGL | Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] | 5 | UniProt NCBI |
| PPP1R3D | Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1 regulatory subunit 6) (PP1 subunit R6) (Protein phosphatase 1-binding subunit R6) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0044042 | 5.29818734012e-19 | 1.0 | PPP1R3B STBD1 PPP1R3C PPP1R3D GYG2 AGL GYS2 PYGL PPP1R3F | glucan metabolic process |
| GO:0005977 | 5.29818734012e-19 | 1.0 | PPP1R3B STBD1 PPP1R3C PPP1R3D GYG2 AGL GYS2 PYGL PPP1R3F | glycogen metabolic process |
| GO:0006112 | 2.1996436026e-18 | 1.0 | PPP1R3B STBD1 PPP1R3C PPP1R3D GYG2 AGL GYS2 PYGL PPP1R3F | energy reserve metabolic process |
| GO:0005976 | 1.03682841487e-17 | 1.0 | PPP1R3B STBD1 PPP1R3C PPP1R3D GYG2 AGL GYS2 PYGL PPP1R3F | polysaccharide metabolic process |
| GO:0015980 | 1.90798933994e-12 | 1.0 | PPP1R3B STBD1 PPP1R3C PPP1R3D GYG2 AGL GYS2 PYGL PPP1R3F | energy derivation by oxidation of organic compounds |
| GO:2001069 | 6.80576638125e-12 | 0.555555555556 | PPP1R3C STBD1 PPP1R3D PPP1R3B PPP1R3F | glycogen binding |
| GO:0005975 | 3.98986067767e-11 | 1.0 | PPP1R3B STBD1 PPP1R3C PPP1R3D GYG2 AGL GYS2 PYGL PPP1R3F | carbohydrate metabolic process |
| GO:0006091 | 8.07188827962e-11 | 1.0 | PPP1R3B STBD1 PPP1R3C PPP1R3D GYG2 AGL GYS2 PYGL PPP1R3F | generation of precursor metabolites and energy |
| REAC:R-HSA-8982491 | 2.27556107573e-10 | 0.555555555556 | GYG2 PYGL AGL GYS2 PPP1R3C | Glycogen metabolism |
| GO:0005978 | 2.80198489354e-10 | 0.666666666667 | PPP1R3B PPP1R3C PPP1R3D GYG2 GYS2 PPP1R3F | glycogen biosynthetic process |
| GO:0009250 | 2.80198489354e-10 | 0.666666666667 | PPP1R3B PPP1R3C PPP1R3D GYG2 GYS2 PPP1R3F | glucan biosynthetic process |
| GO:0030247 | 5.23446376334e-10 | 0.555555555556 | PPP1R3C STBD1 PPP1R3D PPP1R3B PPP1R3F | polysaccharide binding |
| KEGG:04910 | 1.51444540916e-09 | 0.666666666667 | PPP1R3B PPP1R3C PPP1R3D GYS2 PYGL PPP1R3F | Insulin signaling pathway |
| GO:0000271 | 3.31133268521e-09 | 0.666666666667 | PPP1R3B PPP1R3C PPP1R3D GYG2 GYS2 PPP1R3F | polysaccharide biosynthetic process |
| KEGG:00500 | 4.21629290299e-08 | 0.444444444444 | GYG2 AGL GYS2 PYGL | Starch and sucrose metabolism |
| KEGG:04931 | 7.62657623815e-08 | 0.555555555556 | PPP1R3C PYGL PPP1R3D PPP1R3B GYS2 | Insulin resistance |
| GO:0030246 | 1.24537303882e-07 | 0.666666666667 | PPP1R3B PPP1R3C PPP1R3D STBD1 PYGL PPP1R3F | carbohydrate binding |
| WP:WP500 | 3.95974538078e-07 | 0.444444444444 | GYG2 AGL GYS2 PYGL | Glycogen synthesis and degradation |
| GO:0000272 | 4.17167775941e-07 | 0.444444444444 | STBD1 AGL PPP1R3B PYGL | polysaccharide catabolic process |
| GO:0009251 | 4.17167775941e-07 | 0.444444444444 | STBD1 AGL PPP1R3B PYGL | glucan catabolic process |
| GO:0005980 | 4.17167775941e-07 | 0.444444444444 | STBD1 AGL PPP1R3B PYGL | glycogen catabolic process |
| WP:WP4861 | 5.47480563025e-07 | 0.444444444444 | PPP1R3C PPP1R3D PPP1R3B PPP1R3F | Endoplasmic reticulum stress response in coronavirus infection |
| GO:0016051 | 1.64878664814e-06 | 0.666666666667 | PPP1R3B PPP1R3C PPP1R3D GYG2 GYS2 PPP1R3F | carbohydrate biosynthetic process |
| WP:WP5173 | 4.20088523308e-06 | 0.333333333333 | GYG2 GYS2 PYGL | Disorders of galactose metabolism |
| GO:0008157 | 4.51189669214e-06 | 0.444444444444 | PPP1R3C PPP1R3D PPP1R3B PPP1R3F | protein phosphatase 1 binding |
| GO:0000164 | 6.01421448879e-06 | 0.444444444444 | PPP1R3C PPP1R3D PPP1R3B PPP1R3F | protein phosphatase type 1 complex |
| REAC:R-HSA-70221 | 1.09103559608e-05 | 0.333333333333 | GYG2 AGL PYGL | Glycogen breakdown (glycogenolysis) |
| REAC:R-HSA-3229121 | 1.38816297355e-05 | 0.333333333333 | GYG2 GYS2 PPP1R3C | Glycogen storage diseases |
| REAC:R-HSA-3322077 | 1.38816297355e-05 | 0.333333333333 | GYG2 GYS2 PPP1R3C | Glycogen synthesis |
| GO:0010962 | 2.41328111219e-05 | 0.444444444444 | PPP1R3C PPP1R3D PPP1R3B PPP1R3F | regulation of glucan biosynthetic process |
| GO:0005979 | 2.41328111219e-05 | 0.444444444444 | PPP1R3C PPP1R3D PPP1R3B PPP1R3F | regulation of glycogen biosynthetic process |
| REAC:R-HSA-71387 | 4.47156209084e-05 | 0.555555555556 | GYG2 PYGL AGL GYS2 PPP1R3C | Metabolism of carbohydrates |
| GO:0032885 | 4.92672936912e-05 | 0.444444444444 | PPP1R3C PPP1R3D PPP1R3B PPP1R3F | regulation of polysaccharide biosynthetic process |
| GO:0070873 | 4.92672936912e-05 | 0.444444444444 | PPP1R3C PPP1R3D PPP1R3B PPP1R3F | regulation of glycogen metabolic process |
| REAC:R-HSA-3858516 | 7.98825873128e-05 | 0.222222222222 | GYG2 GYS2 | Glycogen storage disease type 0 (liver GYS2) |
| GO:0032881 | 9.02134234826e-05 | 0.444444444444 | PPP1R3C PPP1R3D PPP1R3B PPP1R3F | regulation of polysaccharide metabolic process |
| REAC:R-HSA-5663084 | 0.000154071905864 | 0.333333333333 | GYG2 GYS2 PPP1R3C | Diseases of carbohydrate metabolism |
| REAC:R-HSA-3878781 | 0.000239571230342 | 0.222222222222 | GYG2 GYS2 | Glycogen storage disease type IV (GBE1) |
| GO:1903293 | 0.000753968512946 | 0.444444444444 | PPP1R3C PPP1R3D PPP1R3B PPP1R3F | phosphatase complex |
| GO:0008287 | 0.000753968512946 | 0.444444444444 | PPP1R3C PPP1R3D PPP1R3B PPP1R3F | protein serine/threonine phosphatase complex |
| GO:0043255 | 0.0012907232035 | 0.444444444444 | PPP1R3C PPP1R3D PPP1R3B PPP1R3F | regulation of carbohydrate biosynthetic process |
| GO:0043467 | 0.0111978844793 | 0.444444444444 | PPP1R3C PPP1R3D PPP1R3B PPP1R3F | regulation of generation of precursor metabolites and energy |
| GO:0019903 | 0.0148319287105 | 0.444444444444 | PPP1R3C PPP1R3D PPP1R3B PPP1R3F | protein phosphatase binding |
| GO:0016052 | 0.0148319287105 | 0.444444444444 | STBD1 AGL PPP1R3B PYGL | carbohydrate catabolic process |
| GO:0006109 | 0.0192812476566 | 0.444444444444 | PPP1R3C PPP1R3D PPP1R3B PPP1R3F | regulation of carbohydrate metabolic process |
| WP:WP410 | 0.0249090322132 | 0.222222222222 | PPP1R3C STBD1 | Exercise induced circadian regulation |
| REAC:R-HSA-5668914 | 0.0387699686006 | 0.333333333333 | GYG2 GYS2 PPP1R3C | Diseases of metabolism |
| HP:0003077 | 0.0482177591518 | 0.333333333333 | PYGL GYS2 AGL | Hyperlipidemia |
| GO:0019902 | 0.0489603106588 | 0.444444444444 | PPP1R3C PPP1R3D PPP1R3B PPP1R3F | phosphatase binding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| STBD1 | AGL | 1.0 | 0.216 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| STBD1 | PYGB | 0.999 | 0.185 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| PPP1R3B | AGL | 0.999 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| PYGB | PYGL | 0.998 | 0.366 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM WMM_only |
| PPP1R3B | PPP1R3D | 0.998 | hein_WMM bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| GYG2 | STBD1 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PPP1R3B | PYGB | 0.996 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GYG2 | AGL | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STBD1 | GYS2 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PPP1R3C | STBD1 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| STBD1 | PPP1R3D | 0.992 | 0.112 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PPP1R3F | STBD1 | 0.99 | 0.104 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| STBD1 | PYGL | 0.988 | 0.228 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GYG2 | GYS2 | 0.987 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PPP1R3B | STBD1 | 0.986 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GYG2 | PPP1R3F | 0.981 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PPP1R3C | PPP1R3D | 0.973 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PPP1R3C | AGL | 0.97 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GYS2 | PYGB | 0.957 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PPP1R3B | GYS2 | 0.949 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GYG2 | PYGB | 0.948 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| PPP1R3F | PPP1R3D | 0.925 | 0.14 | bioplex_WMM bioplex3_WMM WMM_only |
| PYGB | PPP1R3D | 0.909 | 0.082 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| PYGB | AGL | 0.898 | 0.206 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| PPP1R3B | PPP1R3F | 0.894 | bioplex_WMM bioplex3_WMM WMM_only | |
| GYS2 | AGL | 0.893 | bioplex_WMM bioplex3_WMM WMM_only | |
| AGL | PPP1R3D | 0.871 | 0.078 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| GYS2 | PPP1R3D | 0.866 | bioplex_WMM bioplex3_WMM WMM_only | |
| PPP1R3F | PYGB | 0.865 | 0.07 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| PPP1R3F | AGL | 0.812 | 0.05 | bioplex3_WMM WMM_only |
| PPP1R3F | GYS2 | 0.745 | bioplex3_WMM WMM_only | |
| PPP1R3B | PYGL | 0.729 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PPP1R3F | PYGL | 0.569 | 0.03 | bioplex3_WMM WMM_only |
| PYGL | PPP1R3D | 0.515 | 0.044 | bioplex_WMM bioplex3_WMM WMM_only |
| PPP1R3C | GYS2 | 0.268 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GYG2 | PPP1R3D | 0.263 | bioplex_WMM bioplex3_WMM WMM_only | |
| GYS2 | PYGL | 0.215 | bioplex_WMM bioplex3_WMM WMM_only | |
| PYGL | AGL | 0.172 | 0.054 | bioplex_WMM bioplex3_WMM fraction |
| PPP1R3B | GYG2 | 0.133 | bioplex3_WMM WMM_only | |
| GYG2 | PYGL | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PPP1R3C | PYGL | 0.005 | bioplex3_HEK293 bioplex () |
Related Complexes