hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01413.1
Confidence: Extremely High  
ProteinsGenename | Protein Name | Uniprot Annotation Score | Links |
---|---|---|---|
WDR7 | WD repeat-containing protein 7 (Rabconnectin-3 beta) (TGF-beta resistance-associated protein TRAG) | 3 | UniProt   NCBI |
NCOA7 | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | 5 | UniProt   NCBI |
DMXL1 | DmX-like protein 1 (X-like 1 protein) | 3 | UniProt   NCBI |
TBC1D24 | TBC1 domain family member 24 | 5 | UniProt   NCBI |
ATP6V1C1 | V-type proton ATPase subunit C 1 (V-ATPase subunit C 1) (Vacuolar proton pump subunit C 1) | 5 | UniProt   NCBI |
ATP6V1G2 | V-type proton ATPase subunit G 2 (V-ATPase subunit G 2) (V-ATPase 13 kDa subunit 2) (Vacuolar proton pump subunit G 2) | 5 | UniProt   NCBI |
ATP6V1B2 | V-type proton ATPase subunit B, brain isoform (V-ATPase subunit B 2) (Endomembrane proton pump 58 kDa subunit) (HO57) (Vacuolar proton pump subunit B 2) | 5 | UniProt   NCBI |
ATP6V1E2 | V-type proton ATPase subunit E 2 (V-ATPase subunit E 2) (Vacuolar proton pump subunit E 2) | 4 | UniProt   NCBI |
ATP6V1B1 | V-type proton ATPase subunit B, kidney isoform (V-ATPase subunit B 1) (Endomembrane proton pump 58 kDa subunit) (Vacuolar proton pump subunit B 1) | 5 | UniProt   NCBI |
ATP6V1D | V-type proton ATPase subunit D (V-ATPase subunit D) (V-ATPase 28 kDa accessory protein) (Vacuolar proton pump subunit D) | 5 | UniProt   NCBI |
ATP6V1E1 | V-type proton ATPase subunit E 1 (V-ATPase subunit E 1) (V-ATPase 31 kDa subunit) (p31) (Vacuolar proton pump subunit E 1) | 5 | UniProt   NCBI |
ATP6V1C2 | V-type proton ATPase subunit C 2 (V-ATPase subunit C 2) (Vacuolar proton pump subunit C 2) | 5 | UniProt   NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
  KEGG:04966 | 1.45564800021e-16 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | Collecting duct acid secretion |
  REAC:R-HSA-917977 | 3.56918674858e-15 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | Transferrin endocytosis and recycling |
  REAC:R-HSA-77387 | 3.56918674858e-15 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | Insulin receptor recycling |
  REAC:R-HSA-1222556 | 7.92092435997e-15 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | ROS and RNS production in phagocytes |
  KEGG:05110 | 2.68027886028e-14 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | Vibrio cholerae infection |
  KEGG:04721 | 2.27286767894e-13 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | Synaptic vesicle cycle |
  KEGG:05120 | 3.2537080699e-13 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | Epithelial cell signaling in Helicobacter pylori infection |
  REAC:R-HSA-917937 | 4.00965162968e-13 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | Iron uptake and transport |
  REAC:R-HSA-9639288 | 4.61870627626e-13 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | Amino acids regulate mTORC1 |
  KEGG:05323 | 5.69431590472e-13 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | Rheumatoid arthritis |
  GO:0033180 | 7.88137762893e-13 | 0.545454545455 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1B2 ATP6V1C1 ATP6V1C2 | proton-transporting V-type ATPase, V1 domain |
  GO:0000221 | 7.88137762893e-13 | 0.545454545455 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1B2 ATP6V1C1 ATP6V1C2 | vacuolar proton-transporting V-type ATPase, V1 domain |
  REAC:R-HSA-74752 | 1.47042255243e-12 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | Signaling by Insulin receptor |
  GO:0033178 | 2.10753895288e-11 | 0.545454545455 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1B2 ATP6V1C1 ATP6V1C2 | proton-transporting two-sector ATPase complex, catalytic domain |
  KEGG:00190 | 3.88364735932e-11 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | Oxidative phosphorylation |
  KEGG:04145 | 6.81640262546e-11 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | Phagosome |
  GO:0016471 | 1.26873887387e-10 | 0.545454545455 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1B2 ATP6V1C1 ATP6V1C2 | vacuolar proton-transporting V-type ATPase complex |
  KEGG:04150 | 1.53957815812e-10 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | mTOR signaling pathway |
  GO:0033176 | 1.71602506793e-10 | 0.545454545455 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1B2 ATP6V1C1 ATP6V1C2 | proton-transporting V-type ATPase complex |
  REAC:R-HSA-983712 | 2.21730235466e-10 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | Ion channel transport |
  REAC:R-HSA-9711097 | 9.90993001967e-10 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | Cellular response to starvation |
  GO:0046961 | 1.91798962418e-09 | 0.454545454545 | ATP6V1E2 ATP6V1C2 ATP6V1E1 ATP6V1C1 ATP6V1B2 | proton-transporting ATPase activity, rotational mechanism |
  GO:0044769 | 1.91798962418e-09 | 0.454545454545 | ATP6V1E2 ATP6V1C2 ATP6V1E1 ATP6V1C1 ATP6V1B2 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism |
  GO:0042625 | 3.28685663218e-09 | 0.454545454545 | ATP6V1E2 ATP6V1C2 ATP6V1E1 ATP6V1C1 ATP6V1B2 | ATPase-coupled ion transmembrane transporter activity |
  GO:0016469 | 1.19260547778e-08 | 0.545454545455 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1B2 ATP6V1C1 ATP6V1C2 | proton-transporting two-sector ATPase complex |
  KEGG:05165 | 1.94945399991e-08 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | Human papillomavirus infection |
  GO:0016241 | 7.4438357393e-08 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | regulation of macroautophagy |
  REAC:R-HSA-9006934 | 1.44995773378e-06 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | Signaling by Receptor Tyrosine Kinases |
  GO:0019829 | 1.79357540166e-06 | 0.454545454545 | ATP6V1E2 ATP6V1C2 ATP6V1E1 ATP6V1C1 ATP6V1B2 | ATPase-coupled monoatomic cation transmembrane transporter activity |
  REAC:R-HSA-382551 | 6.21289103761e-06 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | Transport of small molecules |
  GO:0016236 | 1.13785299554e-05 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | macroautophagy |
  GO:1904949 | 1.47519352579e-05 | 0.545454545455 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1B2 ATP6V1C1 ATP6V1C2 | ATPase complex |
  GO:0010506 | 1.8673355144e-05 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | regulation of autophagy |
  GO:0042626 | 4.9239332795e-05 | 0.454545454545 | ATP6V1E2 ATP6V1C2 ATP6V1E1 ATP6V1C1 ATP6V1B2 | ATPase-coupled transmembrane transporter activity |
  REAC:R-HSA-2262752 | 5.06061407289e-05 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | Cellular responses to stress |
  REAC:R-HSA-8953897 | 5.40576677405e-05 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | Cellular responses to stimuli |
  GO:0015078 | 0.000198563436287 | 0.454545454545 | ATP6V1E2 ATP6V1C2 ATP6V1E1 ATP6V1C1 ATP6V1B2 | proton transmembrane transporter activity |
  REAC:R-HSA-168249 | 0.000205823523349 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | Innate Immune System |
  WP:WP4917 | 0.000298151339704 | 0.272727272727 | ATP6V1D ATP6V1C1 ATP6V1E1 | Proximal tubule transport |
  GO:0061919 | 0.000354645297382 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | process utilizing autophagic mechanism |
  GO:0006914 | 0.000354645297382 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | autophagy |
  HP:0031423 | 0.000476871103789 | 0.181818181818 | TBC1D24 ATP6V1B2 | Small cerebellar cortex |
  KEGG:01100 | 0.000521150537762 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | Metabolic pathways |
  GO:0015399 | 0.00105509556543 | 0.454545454545 | ATP6V1E2 ATP6V1C2 ATP6V1E1 ATP6V1C1 ATP6V1B2 | primary active transmembrane transporter activity |
  GO:0031329 | 0.00129547845224 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | regulation of cellular catabolic process |
  HP:0031282 | 0.00143002591111 | 0.181818181818 | TBC1D24 ATP6V1B2 | Malalignment of the great toenail |
  HP:0010347 | 0.00143002591111 | 0.181818181818 | TBC1D24 ATP6V1B2 | Aplasia/Hypoplasia of the phalanges of the 2nd toe |
  HP:0010324 | 0.00143002591111 | 0.181818181818 | TBC1D24 ATP6V1B2 | Abnormal morphology of phalanx of the 2nd toe |
  GO:0022853 | 0.00242084971071 | 0.454545454545 | ATP6V1E2 ATP6V1C2 ATP6V1E1 ATP6V1C1 ATP6V1B2 | active monoatomic ion transmembrane transporter activity |
  HP:0011326 | 0.00285887750413 | 0.181818181818 | TBC1D24 ATP6V1B2 | Anterior plagiocephaly |
  GO:1902600 | 0.00290404386312 | 0.363636363636 | ATP6V1D ATP6V1E1 ATP6V1C1 ATP6V1B2 | proton transmembrane transport |
  GO:0005774 | 0.00390314491227 | 0.545454545455 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1B2 ATP6V1C1 ATP6V1C2 | vacuolar membrane |
  KEGG:04142 | 0.00465681750503 | 0.272727272727 | DMXL1 WDR7 NCOA7 | Lysosome |
  HP:0031422 | 0.00476283944706 | 0.181818181818 | TBC1D24 ATP6V1B2 | Abnormal cerebellar cortex morphology |
  HPA:0100212 | 0.00547614982411 | 0.727272727273 | ATP6V1D ATP6V1G2 ATP6V1E1 DMXL1 WDR7 NCOA7 ATP6V1C1 ATP6V1B2 | cerebral cortex; neuropil[>=Medium] |
  REAC:R-HSA-168256 | 0.0151221083486 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | Immune System |
  GO:0009894 | 0.0169966217429 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | regulation of catabolic process |
  HP:0100797 | 0.0171180788587 | 0.181818181818 | TBC1D24 ATP6V1B2 | Toenail dysplasia |
  HP:0000675 | 0.0171180788587 | 0.181818181818 | TBC1D24 ATP6V1B2 | Macrodontia of permanent maxillary central incisor |
  HP:0006891 | 0.0171180788587 | 0.181818181818 | TBC1D24 ATP6V1E1 | Thick cerebral cortex |
  HP:0000121 | 0.0192536843846 | 0.272727272727 | TBC1D24 ATP6V1B2 ATP6V1E1 | Nephrocalcinosis |
  HP:0010497 | 0.0213888128664 | 0.181818181818 | TBC1D24 ATP6V1B2 | Sirenomelia |
  HP:0012402 | 0.0261311487161 | 0.181818181818 | TBC1D24 ATP6V1B2 | Increased urine alpha-ketoglutarate concentration |
  HP:0000200 | 0.0261311487161 | 0.181818181818 | TBC1D24 ATP6V1B2 | Short lingual frenulum |
  HP:0010319 | 0.0261311487161 | 0.181818181818 | TBC1D24 ATP6V1B2 | Abnormal second toe morphology |
  HP:0011081 | 0.0261311487161 | 0.181818181818 | TBC1D24 ATP6V1B2 | Incisor macrodontia |
  HP:0008110 | 0.031344503338 | 0.181818181818 | TBC1D24 ATP6V1B2 | Equinovarus deformity |
  HP:0011409 | 0.0370282941421 | 0.181818181818 | TBC1D24 ATP6V1B2 | Abnormal placental membrane morphology |
  HP:0012401 | 0.0370282941421 | 0.181818181818 | TBC1D24 ATP6V1B2 | Abnormal urine alpha-ketoglutarate concentration |
  HP:0000187 | 0.0370282941421 | 0.181818181818 | TBC1D24 ATP6V1B2 | Broad alveolar ridges |
  GO:0022804 | 0.047041217147 | 0.454545454545 | ATP6V1E2 ATP6V1C2 ATP6V1E1 ATP6V1C1 ATP6V1B2 | active transmembrane transporter activity |
  REAC:R-HSA-162582 | 0.0495465193669 | 0.636363636364 | ATP6V1D ATP6V1E1 ATP6V1G2 ATP6V1C2 ATP6V1E2 ATP6V1C1 ATP6V1B2 | Signal Transduction |
  HP:0004626 | 0.0498048563326 | 0.181818181818 | TBC1D24 ATP6V1B2 | Lumbar scoliosis |
Edges
Protein 1 | Protein 2 | Score | ProteomeHD |
---|---|---|---|
 ATP6V1B2 |  ATP6V1D | 1.0 | 0.65           |
 ATP6V1D |  ATP6V1E1 | 1.0 | 0.792           |
 ATP6V1E2 |  ATP6V1C2 | 1.0 |            |
 ATP6V1B2 |  ATP6V1E1 | 1.0 | 0.93           |
 ATP6V1B1 |  ATP6V1D | 1.0 |            |
 ATP6V1E2 |  ATP6V1B1 | 1.0 |            |
 ATP6V1D |  ATP6V1C2 | 1.0 |            |
 ATP6V1E1 |  ATP6V1C2 | 0.999 |            |
 ATP6V1G2 |  ATP6V1E2 | 0.999 |            |
 ATP6V1B1 |  ATP6V1E1 | 0.999 |            |
 ATP6V1C1 |  ATP6V1B1 | 0.999 |            |
 ATP6V1B2 |  ATP6V1B1 | 0.999 |            |
 ATP6V1G2 |  ATP6V1C2 | 0.999 |            |
 ATP6V1E2 |  ATP6V1D | 0.999 |            |
 ATP6V1B2 |  ATP6V1E2 | 0.999 |            |
 ATP6V1B2 |  ATP6V1C2 | 0.999 |            |
 ATP6V1C1 |  ATP6V1B2 | 0.999 | 0.304           |
 ATP6V1C1 |  ATP6V1D | 0.999 | 0.188           |
 ATP6V1C1 |  ATP6V1C2 | 0.999 |            |
 ATP6V1G2 |  ATP6V1D | 0.999 | 0.136           |
 ATP6V1C1 |  ATP6V1G2 | 0.998 | 0.058           |
 WDR7 |  ATP6V1B1 | 0.998 |            |
 NCOA7 |  ATP6V1B1 | 0.998 |            |
 WDR7 |  ATP6V1G2 | 0.997 |            |
 DMXL1 |  ATP6V1B1 | 0.997 |            |
 ATP6V1G2 |  ATP6V1E1 | 0.997 | 0.118666666667           |
 ATP6V1G2 |  ATP6V1B2 | 0.997 | 0.156           |
 NCOA7 |  ATP6V1B2 | 0.996 | 0.074           |
 TBC1D24 |  ATP6V1B2 | 0.994 | 0.078           |
 NCOA7 |  ATP6V1D | 0.993 | 0.024           |
 DMXL1 |  ATP6V1G2 | 0.992 | 0.0743333333333           |
 TBC1D24 |  ATP6V1D | 0.992 | 0.052           |
 DMXL1 |  ATP6V1B2 | 0.991 | 0.078           |
 ATP6V1G2 |  ATP6V1B1 | 0.99 |            |
 ATP6V1B1 |  ATP6V1C2 | 0.988 |            |
 TBC1D24 |  ATP6V1B1 | 0.987 |            |
 ATP6V1C1 |  ATP6V1E1 | 0.987 | 0.23           |
 ATP6V1C1 |  ATP6V1E2 | 0.982 |            |
 WDR7 |  ATP6V1B2 | 0.98 |            |
 WDR7 |  DMXL1 | 0.978 |            |
 ATP6V1E2 |  ATP6V1E1 | 0.978 |            |
 DMXL1 |  ATP6V1C2 | 0.975 |            |
 NCOA7 |  ATP6V1G2 | 0.972 | 0.072           |
 NCOA7 |  ATP6V1E2 | 0.969 |            |
 WDR7 |  NCOA7 | 0.964 |            |
 NCOA7 |  DMXL1 | 0.964 | 0.06           |
 NCOA7 |  ATP6V1C1 | 0.964 | 0.078           |
 NCOA7 |  ATP6V1C2 | 0.964 |            |
 DMXL1 |  ATP6V1E2 | 0.958 |            |
 WDR7 |  ATP6V1E2 | 0.957 |            |
 WDR7 |  ATP6V1C2 | 0.952 |            |
 WDR7 |  ATP6V1C1 | 0.946 |            |
 DMXL1 |  ATP6V1E1 | 0.946 | 0.044           |
 DMXL1 |  ATP6V1C1 | 0.946 | 0.108           |
 DMXL1 |  ATP6V1D | 0.946 | 0.064           |
 NCOA7 |  ATP6V1E1 | 0.936 | 0.052           |
 WDR7 |  ATP6V1E1 | 0.933 |            |
 WDR7 |  ATP6V1D | 0.933 |            |
 TBC1D24 |  ATP6V1G2 | 0.811 | 0.078           |
 TBC1D24 |  WDR7 | 0.799 |            |
 TBC1D24 |  DMXL1 | 0.799 | 0.022           |
 TBC1D24 |  NCOA7 | 0.672 | 0.058           |
 TBC1D24 |  ATP6V1E2 | 0.672 |            |
 TBC1D24 |  ATP6V1E1 | 0.654 | 0.046           |
 TBC1D24 |  ATP6V1C1 | 0.654 | 0.11           |
 TBC1D24 |  ATP6V1C2 | 0.646 |            |
Related Complexes