hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_01422.1

Complex Portal: CPX-11266

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
VAPB	Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C)	5	UniProt NCBI
PRRT4	Proline-rich transmembrane protein 4	3	UniProt NCBI
PITPNM1	Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2)	5	UniProt NCBI
TTC39B	Tetratricopeptide repeat protein 39B (TPR repeat protein 39B)	4	UniProt NCBI
OSBP	Oxysterol-binding protein 1	5	UniProt NCBI
PITPNM2	Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3)	5	UniProt NCBI
OSBP2	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (ORP-4) (OSBP-related protein 4)	5	UniProt NCBI
USP20	Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2)	5	UniProt NCBI
OSBPL9	Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9)	5	UniProt NCBI
SLC22A15	Solute carrier family 22 member 15 (Fly-like putative transporter 1) (Flipt 1)	5	UniProt NCBI
VAPA	Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33)	5	UniProt NCBI
OSBPL11	Oxysterol-binding protein-related protein 11 (ORP-11) (OSBP-related protein 11)	5	UniProt NCBI
USP33	Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (VHL-interacting deubiquitinating enzyme 1) (hVDU1)	5	UniProt NCBI
DOP1A	Protein dopey-1	3	UniProt NCBI
ACBD4	Acyl-CoA-binding domain-containing protein 4	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0005319	4.91555016284e-05	0.4	PITPNM1 OSBPL9 OSBPL11 OSBP2 OSBP PITPNM2	lipid transporter activity
REAC:R-HSA-556833	0.000313432399699	0.466666666667	VAPA PITPNM1 OSBPL9 VAPB ACBD4 OSBP PITPNM2	Metabolism of lipids
GO:0015248	0.000529882930462	0.266666666667	OSBPL11 OSBPL9 OSBP OSBP2	sterol transporter activity
REAC:R-HSA-1660661	0.00153746006239	0.2	VAPA VAPB OSBP	Sphingolipid de novo biosynthesis
REAC:R-HSA-1483226	0.00293854252908	0.133333333333	PITPNM1 PITPNM2	Synthesis of PI
GO:0010876	0.00544026155866	0.4	VAPA PITPNM1 OSBPL11 VAPB TTC39B OSBP	lipid localization
GO:0032934	0.00624235062122	0.266666666667	OSBPL11 OSBPL9 OSBP OSBP2	sterol binding
REAC:R-HSA-428157	0.0156002721805	0.2	VAPA VAPB OSBP	Sphingolipid metabolism
GO:0008289	0.0158764845936	0.466666666667	PITPNM1 ACBD4 OSBPL9 OSBPL11 OSBP2 OSBP PITPNM2	lipid binding
GO:0005496	0.0220096981088	0.266666666667	OSBPL11 OSBPL9 OSBP OSBP2	steroid binding
TF:M10101	0.0406724253826	0.866666666667	VAPA PITPNM1 ACBD4 TTC39B USP20 VAPB OSBP2 OSBPL11 PRRT4 OSBP SLC22A15 PITPNM2 DOP1A	Factor: TGIF; motif: TGACAGS
KEGG:04979	0.0449150412235	0.133333333333	VAPA VAPB	Cholesterol metabolism
GO:0030301	0.0489960872878	0.266666666667	VAPA TTC39B VAPB OSBP	cholesterol transport

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
VAPA	VAPB	1.0	0.746	structurally_consistent (dimer)
VAPB	OSBPL9	0.999	0.11
VAPB	OSBPL11	0.999	0.104
PITPNM2	VAPB	0.999	0.099	mutually_exclusive (Q9P0L0)
OSBP	VAPB	0.998	0.206	structurally_consistent (dimer)
OSBP2	VAPB	0.998	0.144810810811
VAPA	OSBPL9	0.998	0.106
OSBPL9	OSBPL11	0.997	0.428
VAPA	OSBPL11	0.997	0.068
SLC22A15	VAPB	0.997
VAPA	OSBP2	0.997	0.142
VAPB	USP33	0.995	0.288
PITPNM1	VAPB	0.992	0.096
VAPA	OSBP	0.992	0.126
VAPB	USP20	0.992	0.246
VAPB	TTC39B	0.99	0.234
USP20	USP33	0.988	0.124
VAPA	PITPNM1	0.983	0.11	structurally_consistent (dimer)
ACBD4	VAPB	0.98	0.2
PRRT4	VAPB	0.975
DOP1A	VAPB	0.958	0.14
SLC22A15	VAPA	0.957
VAPA	PITPNM2	0.944	0.104363095238	structurally_consistent (dimer)
OSBP	OSBP2	0.94	0.122
OSBP	USP33	0.938	0.182
PRRT4	TTC39B	0.904
OSBP2	PRRT4	0.902
SLC22A15	PRRT4	0.902
PRRT4	PITPNM2	0.902
PITPNM1	PRRT4	0.902
SLC22A15	PITPNM1	0.902
SLC22A15	PITPNM2	0.902
PITPNM1	OSBP2	0.897	0.108
OSBP2	PITPNM2	0.897	0.082
PRRT4	OSBPL9	0.892
PRRT4	OSBPL11	0.892
VAPA	USP33	0.89	0.158
PITPNM1	PITPNM2	0.881	0.086	mutually_exclusive (Q9P0L0)
OSBP2	OSBPL9	0.862	0.138
OSBP	OSBPL9	0.821	0.104
PITPNM1	TTC39B	0.793	0.126
PITPNM2	TTC39B	0.793	0.076
OSBPL9	USP33	0.778	0.296
PITPNM2	OSBPL11	0.772	0.07
PITPNM1	OSBPL11	0.772	0.044
PITPNM1	OSBPL9	0.772	0.056
PITPNM2	OSBPL9	0.772	0.062
OSBP	OSBPL11	0.769	0.088
SLC22A15	OSBPL11	0.768
VAPA	ACBD4	0.75	0.0812
PITPNM1	USP20	0.739	0.086
PITPNM2	USP20	0.739	0.066
USP33	TTC39B	0.732	0.088
OSBP	PITPNM2	0.731	0.088
PITPNM1	OSBP	0.731	0.102
PRRT4	USP20	0.73
SLC22A15	OSBP2	0.722
OSBP2	OSBPL11	0.716	0.128
SLC22A15	USP20	0.715
PITPNM1	USP33	0.699	0.054
PITPNM2	USP33	0.699	0.064
USP20	OSBPL9	0.698	0.322
SLC22A15	OSBPL9	0.697
OSBP	PRRT4	0.696
VAPA	USP20	0.693	0.228
PRRT4	USP33	0.675
SLC22A15	USP33	0.663
OSBPL11	USP33	0.63	0.074
OSBP2	USP33	0.614	0.088
OSBPL9	TTC39B	0.611	0.126
OSBPL11	TTC39B	0.611	0.12
USP20	OSBPL11	0.609	0.218
OSBP2	TTC39B	0.604	0.134
OSBP	TTC39B	0.602	0.126
USP20	TTC39B	0.572	0.114
PITPNM1	ACBD4	0.571	0.052
ACBD4	PITPNM2	0.571	0.136
OSBP2	USP20	0.548	0.112
PITPNM1	DOP1A	0.502	0.056
DOP1A	PITPNM2	0.502	0.11
SLC22A15	TTC39B	0.478
OSBP	USP20	0.441	0.282
OSBP2	ACBD4	0.335	0.072
DOP1A	ACBD4	0.333	0.046
SLC22A15	OSBP	0.323
DOP1A	OSBP2	0.303	0.086
VAPA	TTC39B	0.281	0.124
OSBP	DOP1A	0.259	0.204
OSBP	ACBD4	0.234	0.092
DOP1A	PRRT4	0.214
ACBD4	PRRT4	0.214
SLC22A15	ACBD4	0.214
ACBD4	USP20	0.202	0.112
ACBD4	OSBPL9	0.202	0.084
ACBD4	OSBPL11	0.202	0.094
VAPA	PRRT4	0.188
DOP1A	TTC39B	0.172	0.094
ACBD4	TTC39B	0.172	0.082
DOP1A	USP33	0.165	0.07
DOP1A	USP20	0.164	0.132
DOP1A	OSBPL9	0.164	0.066
DOP1A	OSBPL11	0.164	0.076
VAPA	DOP1A	0.155	0.0701944444444
SLC22A15	DOP1A	0.146
ACBD4	USP33	0.144	0.096

Related Complexes

Genename	Complexes
VAPB	huMAP3_00802.1 huMAP3_01422.1 huMAP3_06849.1 huMAP3_07388.1 huMAP3_07722.1 huMAP3_08743.1 huMAP3_09375.1 huMAP3_10725.1 huMAP3_11485.1
PRRT4	huMAP3_00802.1 huMAP3_01083.1 huMAP3_01422.1 huMAP3_03470.1 huMAP3_06849.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1
PITPNM1	huMAP3_00112.1 huMAP3_00443.1 huMAP3_00802.1 huMAP3_01422.1 huMAP3_02032.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_08783.1 huMAP3_10293.1 huMAP3_10464.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1
TTC39B	huMAP3_01422.1 huMAP3_06849.1 huMAP3_08743.1 huMAP3_11660.1
OSBP	huMAP3_00112.1 huMAP3_00802.1 huMAP3_00862.1 huMAP3_01422.1 huMAP3_02032.1 huMAP3_05953.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_08783.1 huMAP3_08942.1 huMAP3_10293.1 huMAP3_10464.1 huMAP3_11340.1 huMAP3_11485.1 huMAP3_12065.1 huMAP3_12460.1 huMAP3_12585.1 huMAP3_12614.1 huMAP3_12946.1 huMAP3_13964.1 huMAP3_14131.1 huMAP3_14473.1 huMAP3_14791.1 huMAP3_14847.1 huMAP3_15032.1
PITPNM2	huMAP3_00802.1 huMAP3_01422.1 huMAP3_06849.1 huMAP3_07722.1 huMAP3_08743.1 huMAP3_09375.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1
OSBP2	huMAP3_00802.1 huMAP3_00862.1 huMAP3_01422.1 huMAP3_03016.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_08783.1 huMAP3_08942.1 huMAP3_11340.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_12460.1 huMAP3_12585.1 huMAP3_12614.1 huMAP3_12946.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1 huMAP3_14847.1
USP20	huMAP3_00802.1 huMAP3_01012.1 huMAP3_01370.1 huMAP3_01422.1 huMAP3_04282.1 huMAP3_06835.1 huMAP3_06849.1 huMAP3_07360.1 huMAP3_10759.1 huMAP3_11328.1 huMAP3_11485.1 huMAP3_12653.1 huMAP3_13990.1 huMAP3_14051.1 huMAP3_14131.1 huMAP3_14473.1 huMAP3_14623.1 huMAP3_14791.1 huMAP3_15032.1
OSBPL9	huMAP3_00802.1 huMAP3_01422.1 huMAP3_01764.1 huMAP3_01831.1 huMAP3_03880.1 huMAP3_08937.1 huMAP3_10293.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_12460.1 huMAP3_12585.1 huMAP3_13000.1 huMAP3_13169.1 huMAP3_14473.1
SLC22A15	huMAP3_00112.1 huMAP3_00802.1 huMAP3_01422.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_08783.1 huMAP3_10293.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_11633.1 huMAP3_11729.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1
VAPA	huMAP3_00112.1 huMAP3_00802.1 huMAP3_01422.1 huMAP3_02032.1 huMAP3_05790.1 huMAP3_07443.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_08783.1 huMAP3_10293.1 huMAP3_10464.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_14473.1
OSBPL11	huMAP3_00802.1 huMAP3_01422.1 huMAP3_01764.1 huMAP3_01831.1 huMAP3_03880.1 huMAP3_08937.1 huMAP3_10293.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_11815.1 huMAP3_13000.1 huMAP3_14177.1 huMAP3_14856.1
USP33	huMAP3_00802.1 huMAP3_01370.1 huMAP3_01422.1 huMAP3_04282.1 huMAP3_06849.1 huMAP3_07360.1 huMAP3_08743.1 huMAP3_10759.1 huMAP3_11340.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_13964.1 huMAP3_14131.1 huMAP3_14473.1 huMAP3_14623.1 huMAP3_14791.1 huMAP3_15032.1
DOP1A	huMAP3_00162.1 huMAP3_00802.1 huMAP3_01422.1 huMAP3_06849.1 huMAP3_07612.1 huMAP3_08201.1 huMAP3_08743.1 huMAP3_11485.1 huMAP3_12705.1 huMAP3_13513.1
ACBD4	huMAP3_00802.1 huMAP3_01422.1 huMAP3_02416.1 huMAP3_02444.1 huMAP3_06849.1 huMAP3_08743.1 huMAP3_11485.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_01422.1

Complex Portal: CPX-11266