hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_01441.1
Complex Portal: CPX-21394
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ROCK1 | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | 5 | UniProt NCBI |
| ROCK2 | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4962 | 3.31996874241e-05 | 1.0 | ROCK1 ROCK2 | Airway smooth muscle cell contraction |
| WP:WP524 | 0.00022473634564 | 1.0 | ROCK1 ROCK2 | G13 signaling pathway |
| REAC:R-HSA-416572 | 0.000292198259614 | 1.0 | ROCK1 ROCK2 | Sema4D induced cell migration and growth-cone collapse |
| REAC:R-HSA-5627117 | 0.000292198259614 | 1.0 | ROCK1 ROCK2 | RHO GTPases Activate ROCKs |
| REAC:R-HSA-400685 | 0.000432316723289 | 1.0 | ROCK1 ROCK2 | Sema4D in semaphorin signaling |
| REAC:R-HSA-9013422 | 0.000432316723289 | 1.0 | ROCK1 ROCK2 | RHOBTB1 GTPase cycle |
| GO:1905205 | 0.000468200720083 | 1.0 | ROCK1 ROCK2 | positive regulation of connective tissue replacement |
| GO:0072518 | 0.000468200720083 | 1.0 | ROCK1 ROCK2 | Rho-dependent protein serine/threonine kinase activity |
| WP:WP2272 | 0.000500549133471 | 1.0 | ROCK1 ROCK2 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-3928663 | 0.000555347569442 | 1.0 | ROCK1 ROCK2 | EPHA-mediated growth cone collapse |
| KEGG:04670 | 0.0005941922333 | 1.0 | ROCK1 ROCK2 | Leukocyte transendothelial migration |
| KEGG:04520 | 0.0005941922333 | 1.0 | ROCK1 ROCK2 | Adherens junction |
| KEGG:04270 | 0.000741317806799 | 1.0 | ROCK1 ROCK2 | Vascular smooth muscle contraction |
| KEGG:04611 | 0.000772693757832 | 1.0 | ROCK1 ROCK2 | Platelet activation |
| KEGG:04071 | 0.000853978605069 | 1.0 | ROCK1 ROCK2 | Sphingolipid signaling pathway |
| REAC:R-HSA-9013407 | 0.000958615342944 | 1.0 | ROCK1 ROCK2 | RHOH GTPase cycle |
| WP:WP2034 | 0.000969601127591 | 1.0 | ROCK1 ROCK2 | Leptin signaling pathway |
| WP:WP1544 | 0.000998544444832 | 1.0 | ROCK1 ROCK2 | MicroRNAs in cardiomyocyte hypertrophy |
| REAC:R-HSA-9706574 | 0.00101671324252 | 1.0 | ROCK1 ROCK2 | RHOBTB GTPase Cycle |
| KEGG:05135 | 0.00106564434727 | 1.0 | ROCK1 ROCK2 | Yersinia infection |
| KEGG:04921 | 0.00112221860095 | 1.0 | ROCK1 ROCK2 | Oxytocin signaling pathway |
| REAC:R-HSA-3928662 | 0.00120125951175 | 1.0 | ROCK1 ROCK2 | EPHB-mediated forward signaling |
| KEGG:04022 | 0.00125991513217 | 1.0 | ROCK1 ROCK2 | cGMP-PKG signaling pathway |
| WP:WP138 | 0.00141354053763 | 1.0 | ROCK1 ROCK2 | Androgen receptor signaling pathway |
| WP:WP185 | 0.00148377064565 | 1.0 | ROCK1 ROCK2 | Integrin mediated cell adhesion |
| KEGG:04062 | 0.00155920593969 | 1.0 | ROCK1 ROCK2 | Chemokine signaling pathway |
| KEGG:04530 | 0.00155920593969 | 1.0 | ROCK1 ROCK2 | Tight junction |
| KEGG:04360 | 0.00191523357059 | 1.0 | ROCK1 ROCK2 | Axon guidance |
| KEGG:04024 | 0.00201635192055 | 1.0 | ROCK1 ROCK2 | cAMP signaling pathway |
| KEGG:05130 | 0.00219956796622 | 1.0 | ROCK1 ROCK2 | Pathogenic Escherichia coli infection |
| KEGG:04510 | 0.00241871191437 | 1.0 | ROCK1 ROCK2 | Focal adhesion |
| KEGG:05205 | 0.00267768543767 | 1.0 | ROCK1 ROCK2 | Proteoglycans in cancer |
| GO:0110061 | 0.0028092043205 | 1.0 | ROCK1 ROCK2 | regulation of angiotensin-activated signaling pathway |
| GO:1903347 | 0.0028092043205 | 1.0 | ROCK1 ROCK2 | negative regulation of bicellular tight junction assembly |
| GO:1905203 | 0.0028092043205 | 1.0 | ROCK1 ROCK2 | regulation of connective tissue replacement |
| REAC:R-HSA-373755 | 0.00292369135789 | 1.0 | ROCK1 ROCK2 | Semaphorin interactions |
| KEGG:05163 | 0.00298087791786 | 1.0 | ROCK1 ROCK2 | Human cytomegalovirus infection |
| KEGG:04810 | 0.00307500577096 | 1.0 | ROCK1 ROCK2 | Regulation of actin cytoskeleton |
| WP:WP3929 | 0.00309012475255 | 1.0 | ROCK1 ROCK2 | Chemokine signaling pathway |
| REAC:R-HSA-9013026 | 0.0031270340064 | 1.0 | ROCK1 ROCK2 | RHOB GTPase cycle |
| REAC:R-HSA-416482 | 0.00323126847328 | 1.0 | ROCK1 ROCK2 | G alpha (12/13) signalling events |
| WP:WP51 | 0.0034595776844 | 1.0 | ROCK1 ROCK2 | Regulation of actin cytoskeleton |
| REAC:R-HSA-9013106 | 0.00355422444443 | 1.0 | ROCK1 ROCK2 | RHOC GTPase cycle |
| KEGG:05131 | 0.00417007523294 | 1.0 | ROCK1 ROCK2 | Shigellosis |
| GO:0035509 | 0.00468200720083 | 1.0 | ROCK1 ROCK2 | negative regulation of myosin-light-chain-phosphatase activity |
| REAC:R-HSA-2682334 | 0.00567479777882 | 1.0 | ROCK1 ROCK2 | EPH-Ephrin signaling |
| REAC:R-HSA-9679191 | 0.0061002794551 | 1.0 | ROCK1 ROCK2 | Potential therapeutics for SARS |
| WP:WP306 | 0.00633262755764 | 1.0 | ROCK1 ROCK2 | Focal adhesion |
| REAC:R-HSA-4420097 | 0.00639247771471 | 1.0 | ROCK1 ROCK2 | VEGFA-VEGFR2 Pathway |
| GO:0097709 | 0.00702301080125 | 1.0 | ROCK1 ROCK2 | connective tissue replacement |
| REAC:R-HSA-194138 | 0.00762962122326 | 1.0 | ROCK1 ROCK2 | Signaling by VEGF |
| GO:0035507 | 0.00983221512175 | 1.0 | ROCK1 ROCK2 | regulation of myosin-light-chain-phosphatase activity |
| GO:0034105 | 0.0131096201623 | 1.0 | ROCK1 ROCK2 | positive regulation of tissue remodeling |
| REAC:R-HSA-8980692 | 0.013456498798 | 1.0 | ROCK1 ROCK2 | RHOA GTPase cycle |
| KEGG:05200 | 0.0161326036311 | 1.0 | ROCK1 ROCK2 | Pathways in cancer |
| CORUM:7424 | 0.0249718442457 | 0.5 | ROCK1 | ISLR2-ROCK1 complex |
| GO:1903140 | 0.0309012475255 | 1.0 | ROCK1 ROCK2 | regulation of establishment of endothelial barrier |
| GO:1901550 | 0.0309012475255 | 1.0 | ROCK1 ROCK2 | regulation of endothelial cell development |
| WP:WP3888 | 0.0309740314556 | 1.0 | ROCK1 ROCK2 | VEGFA VEGFR2 signaling |
| GO:0038166 | 0.0365196561665 | 1.0 | ROCK1 ROCK2 | angiotensin-activated signaling pathway |
| GO:0010613 | 0.0491610756088 | 1.0 | ROCK1 ROCK2 | positive regulation of cardiac muscle hypertrophy |
| GO:2000810 | 0.0491610756088 | 1.0 | ROCK1 ROCK2 | regulation of bicellular tight junction assembly |
| GO:0014742 | 0.0491610756088 | 1.0 | ROCK1 ROCK2 | positive regulation of muscle hypertrophy |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ROCK1 | ROCK2 | 0.993 | 0.186 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
Related Complexes
| Genename | Complexes |
|---|---|
| ROCK1 | huMAP3_01441.1 huMAP3_12086.1 huMAP3_12662.1 huMAP3_12667.1 |
| ROCK2 | huMAP3_01441.1 huMAP3_12086.1 huMAP3_12662.1 huMAP3_12667.1 |