hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01443.1
Complex Portal: CPX-22020
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MDC1 | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | 5 | UniProt NCBI |
| SYNJ2 | Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2) | 5 | UniProt NCBI |
| CD2AP | CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) | 5 | UniProt NCBI |
| STAP1 | Signal-transducing adaptor protein 1 (STAP-1) (BCR downstream-signaling protein 1) (Docking protein BRDG1) (Stem cell adaptor protein 1) | 5 | UniProt NCBI |
| ARHGAP17 | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | 5 | UniProt NCBI |
| SH3D19 | SH3 domain-containing protein 19 (ADAM-binding protein Eve-1) (EEN-binding protein) (EBP) | 5 | UniProt NCBI |
| RTKN2 | Rhotekin-2 (Pleckstrin homology domain-containing family K member 1) (PH domain-containing family K member 1) | 5 | UniProt NCBI |
| SH3KBP1 | SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:846 | 5.49353690762e-07 | 0.375 | SH3KBP1 CD2AP ARHGAP17 | RICH1/AMOT polarity complex, Flag-Rich1 precipitated |
| CORUM:3173 | 0.0499436884912 | 0.125 | SH3KBP1 | CIN85 homotetramer complex |
| CORUM:3174 | 0.0499436884912 | 0.125 | SH3KBP1 | CIN85-BLNK complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CD2AP | SH3KBP1 | 1.0 | 0.246 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM | |
| RTKN2 | SH3KBP1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| MDC1 | SH3KBP1 | 0.998 | 0.076 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| STAP1 | SH3KBP1 | 0.998 | 0.044 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CD2AP | STAP1 | 0.996 | 0.044 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SH3D19 | SH3KBP1 | 0.996 | 0.102 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| ARHGAP17 | SH3KBP1 | 0.994 | 0.066 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| SYNJ2 | SH3KBP1 | 0.954 | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM | |
| SH3D19 | CD2AP | 0.883 | 0.1 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| CD2AP | ARHGAP17 | 0.824 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| MDC1 | RTKN2 | 0.774 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| ARHGAP17 | RTKN2 | 0.709 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CD2AP | RTKN2 | 0.688 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| SYNJ2 | RTKN2 | 0.362 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| SH3D19 | RTKN2 | 0.333 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ARHGAP17 | MDC1 | 0.282 | 0.04 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SH3D19 | SYNJ2 | 0.252 | 0.076 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| ARHGAP17 | SYNJ2 | 0.178 | 0.092 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SH3D19 | ARHGAP17 | 0.145 | 0.102 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CD2AP | MDC1 | 0.092 | 0.058 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| MDC1 | SYNJ2 | 0.014 | 0.12 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| SH3D19 | MDC1 | 0.008 | 0.098 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| CD2AP | SYNJ2 | 0.005 | 0.054 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes