hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_01447.1

Complex Portal: CPX-16378

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
BABAM1	BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex)	5	UniProt NCBI
ABRAXAS1	BRCA1-A complex subunit Abraxas 1 (Coiled-coil domain-containing protein 98) (Protein FAM175A)	5	UniProt NCBI
SHMT2	Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)	5	UniProt NCBI
C9orf85	Uncharacterized protein C9orf85	2	UniProt NCBI
BRCC3	Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36)	5	UniProt NCBI
BABAM2	BRISC and BRCA1-A complex member 2 (BRCA1-A complex subunit BRE) (BRCA1/BRCA2-containing complex subunit 45) (Brain and reproductive organ-expressed protein)	5	UniProt NCBI
ABRAXAS2	BRISC complex subunit Abraxas 2 (Abraxas brother protein 1) (Protein FAM175B)	5	UniProt NCBI
UIMC1	BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-5689901	1.65563793201e-13	0.75	ABRAXAS2 UIMC1 BRCC3 BABAM2 BABAM1 ABRAXAS1	Metalloprotease DUBs
GO:0070552	3.02495762709e-12	0.625	ABRAXAS2 BABAM1 BABAM2 BRCC3 SHMT2	BRISC complex
GO:0070531	2.82232757037e-11	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	BRCA1-A complex
KEGG:03440	3.26549145553e-10	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	Homologous recombination
REAC:R-HSA-5693571	1.26433180723e-08	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	Nonhomologous End-Joining (NHEJ)
REAC:R-HSA-5693565	2.76228622231e-08	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
REAC:R-HSA-5693606	2.96791723199e-08	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	DNA Double Strand Break Response
WP:WP5380	5.53725348463e-08	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	5q35 copy number variation
GO:0007095	7.15510962757e-08	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	mitotic G2 DNA damage checkpoint signaling
REAC:R-HSA-69473	7.81771145919e-08	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	G2/M DNA damage checkpoint
REAC:R-HSA-5693607	9.29382646406e-08	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	Processing of DNA double-strand break ends
REAC:R-HSA-5688426	1.33376910184e-07	0.75	ABRAXAS2 UIMC1 BRCC3 BABAM2 BABAM1 ABRAXAS1	Deubiquitination
REAC:R-HSA-5693567	4.543329189e-07	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
REAC:R-HSA-5693538	5.781370619e-07	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	Homology Directed Repair
GO:0044818	6.86359180245e-07	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	mitotic G2/M transition checkpoint
GO:0031593	1.58134940195e-06	0.625	ABRAXAS2 BABAM2 ABRAXAS1 UIMC1 BRCC3	polyubiquitin modification-dependent protein binding
REAC:R-HSA-5693532	1.60882643463e-06	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	DNA Double-Strand Break Repair
REAC:R-HSA-69481	1.66077446895e-06	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	G2/M Checkpoints
GO:0010972	1.73918590284e-06	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	negative regulation of G2/M transition of mitotic cell cycle
GO:1902750	2.09260049083e-06	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	negative regulation of cell cycle G2/M phase transition
GO:0044773	6.03527005634e-06	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	mitotic DNA damage checkpoint signaling
GO:0044774	8.02725465559e-06	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	mitotic DNA integrity checkpoint signaling
GO:0010389	1.27523062017e-05	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	regulation of G2/M transition of mitotic cell cycle
GO:0070536	1.62421193037e-05	0.5	ABRAXAS2 SHMT2 BRCC3 BABAM2	protein K63-linked deubiquitination
GO:0010212	1.63146572742e-05	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	response to ionizing radiation
GO:1902749	2.18404921906e-05	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	regulation of cell cycle G2/M phase transition
CORUM:7114	2.39226645298e-05	0.25	SHMT2 ABRAXAS2	ABRAXAS2-SHMT2 complex
REAC:R-HSA-69620	2.78130741896e-05	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	Cell Cycle Checkpoints
REAC:R-HSA-73894	4.40742349863e-05	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	DNA Repair
GO:0000077	5.02227339895e-05	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	DNA damage checkpoint signaling
GO:0000086	5.78681307368e-05	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	G2/M transition of mitotic cell cycle
GO:0031570	7.59423271963e-05	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	DNA integrity checkpoint signaling
GO:0044839	9.03094814401e-05	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	cell cycle G2/M phase transition
GO:0045739	9.42197559575e-05	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	positive regulation of DNA repair
GO:0007093	0.000111235137401	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	mitotic cell cycle checkpoint signaling
CORUM:2786	0.000143457417375	0.25	ABRAXAS1 UIMC1	BRCA1 A complex
GO:1901991	0.00023682416585	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	negative regulation of mitotic cell cycle phase transition
CORUM:5400	0.000239030245992	0.25	BRCC3 BABAM2	BRCC complex
GO:0042770	0.000321519574007	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	signal transduction in response to DNA damage
GO:0140030	0.000366173012359	0.625	ABRAXAS2 BABAM2 ABRAXAS1 UIMC1 BRCC3	modification-dependent protein binding
GO:0000075	0.00045612716804	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	cell cycle checkpoint signaling
WP:WP4016	0.000704977993915	0.375	ABRAXAS1 UIMC1 BRCC3	DNA IR damage and cellular response via ATR
GO:0045930	0.000770085925955	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	negative regulation of mitotic cell cycle
GO:0006282	0.00111723306103	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	regulation of DNA repair
GO:1901988	0.00133227426114	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	negative regulation of cell cycle phase transition
REAC:R-HSA-1640170	0.00178497530737	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	Cell Cycle
REAC:R-HSA-597592	0.0018209311458	0.75	ABRAXAS2 UIMC1 BRCC3 BABAM2 BABAM1 ABRAXAS1	Post-translational protein modification
GO:0016579	0.00186685265625	0.5	ABRAXAS2 SHMT2 BRCC3 BABAM2	protein deubiquitination
GO:0010948	0.00289341488904	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	negative regulation of cell cycle process
GO:0051054	0.00301761110433	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	positive regulation of DNA metabolic process
GO:0070646	0.00421661375592	0.5	ABRAXAS2 SHMT2 BRCC3 BABAM2	protein modification by small protein removal
GO:0009314	0.00433782741441	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	response to radiation
GO:1901990	0.00477598146678	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	regulation of mitotic cell cycle phase transition
GO:0140861	0.00519447563198	0.375	BABAM1 BRCC3 UIMC1	DNA repair-dependent chromatin remodeling
GO:0140513	0.00521846176444	0.875	ABRAXAS2 SHMT2 BRCC3 UIMC1 BABAM2 BABAM1 ABRAXAS1	nuclear protein-containing complex
GO:0006302	0.00554969026619	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	double-strand break repair
GO:1903047	0.00597538121158	0.75	ABRAXAS2 UIMC1 BRCC3 BABAM2 BABAM1 ABRAXAS1	mitotic cell cycle process
GO:0045786	0.00970046377374	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	negative regulation of cell cycle
REAC:R-HSA-392499	0.0122053588899	0.75	ABRAXAS2 UIMC1 BRCC3 BABAM2 BABAM1 ABRAXAS1	Metabolism of proteins
GO:0044772	0.0169889279897	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	mitotic cell cycle phase transition
GO:1901987	0.017751758579	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	regulation of cell cycle phase transition
GO:0000278	0.0184613380768	0.75	ABRAXAS2 UIMC1 BRCC3 BABAM2 BABAM1 ABRAXAS1	mitotic cell cycle
GO:0007346	0.0341322153384	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	regulation of mitotic cell cycle
GO:0080135	0.037287218217	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	regulation of cellular response to stress
GO:0051052	0.0475951624611	0.625	BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3	regulation of DNA metabolic process

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
BABAM1	BABAM2	1.0	0.45	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM
BABAM1	ABRAXAS2	1.0	0.334		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM
BABAM1	BRCC3	1.0	0.316		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM
BABAM1	SHMT2	1.0	0.044		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
BRCC3	ABRAXAS2	1.0	0.372		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM
SHMT2	BRCC3	0.999	0.122482269504		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
BABAM1	UIMC1	0.999	0.118		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
BRCC3	BABAM2	0.998	0.802		hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only
BABAM1	ABRAXAS1	0.998	0.304	structurally_consistent (Q9NXR7)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
SHMT2	ABRAXAS2	0.996	0.096	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM
BABAM2	ABRAXAS2	0.99	0.282	structurally_consistent (dimer)	bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM fraction boldt_WMM
C9orf85	ABRAXAS2	0.989	0.194	structurally_consistent (Q9NXR7)	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
SHMT2	BABAM2	0.985	0.136	structurally_consistent (Q15018) structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
ABRAXAS1	BRCC3	0.981	0.32		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
C9orf85	BABAM1	0.981	0.08	mutually_exclusive (Q9NXR7)	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
BABAM2	UIMC1	0.965	0.154		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
C9orf85	BABAM2	0.959	0.116	structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
BRCC3	UIMC1	0.944	0.104		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
ABRAXAS1	SHMT2	0.929	0.16	structurally_consistent (Q9NXR7)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
ABRAXAS1	UIMC1	0.916	0.228		bioplex_WMM bioplex3_WMM WMM_only
ABRAXAS1	BABAM2	0.867	0.17	structurally_consistent (dimer)	bioplex_WMM bioplex3_WMM WMM_only
SHMT2	UIMC1	0.824	0.078		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
ABRAXAS2	UIMC1	0.714	0.058		bioplex_WMM bioplex3_WMM WMM_only
ABRAXAS1	ABRAXAS2	0.4	0.096		bioplex_WMM bioplex3_WMM WMM_only
C9orf85	BRCC3	0.39	0.114		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
C9orf85	SHMT2	0.019	0.116	structurally_consistent (Q9NXR7)	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only

Related Complexes

Genename	Complexes
BABAM1	huMAP3_01447.1 huMAP3_02592.1 huMAP3_08508.1 huMAP3_10482.1 huMAP3_14749.1
ABRAXAS1	huMAP3_01447.1 huMAP3_02592.1 huMAP3_08508.1 huMAP3_10482.1 huMAP3_14749.1
SHMT2	huMAP3_01447.1 huMAP3_02592.1 huMAP3_08187.1 huMAP3_10482.1 huMAP3_14749.1
C9orf85	huMAP3_00889.1 huMAP3_01447.1 huMAP3_02592.1 huMAP3_07950.1 huMAP3_08508.1 huMAP3_10482.1 huMAP3_14749.1
BRCC3	huMAP3_01447.1 huMAP3_02592.1 huMAP3_08508.1 huMAP3_10482.1 huMAP3_14749.1 huMAP3_14839.1
BABAM2	huMAP3_01447.1 huMAP3_02592.1 huMAP3_08508.1 huMAP3_10482.1 huMAP3_14749.1
ABRAXAS2	huMAP3_01447.1 huMAP3_02592.1 huMAP3_08508.1 huMAP3_10482.1 huMAP3_14749.1
UIMC1	huMAP3_01447.1 huMAP3_03354.1 huMAP3_11912.1 huMAP3_14749.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_01447.1

Complex Portal: CPX-16378