hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01457.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HSD3B1 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I) (3-beta-HSD I) (3-beta-hydroxy-5-ene steroid dehydrogenase) (3-beta-hydroxy-Delta(5)-steroid dehydrogenase) (EC 1.1.1.145) (3-beta-hydroxysteroid 3-dehydrogenase) (EC 1.1.1.270) (Delta-5-3-ketosteroid isomerase) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Steroid Delta-isomerase) (EC 5.3.3.1) (Trophoblast antigen FDO161G) | 5 | UniProt NCBI |
| MTHFR | Methylenetetrahydrofolate reductase (NADPH) (EC 1.5.1.53) | 5 | UniProt NCBI |
| HSD3B2 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II) (3-beta-HSD II) (3-beta-HSD adrenal and gonadal type) [Includes: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0011732 | 0.0139947587499 | 1.0 | MTHFR HSD3B2 | Abnormal adrenal morphology |
| HP:0031071 | 0.0139947587499 | 1.0 | MTHFR HSD3B2 | Abnormal endocrine morphology |
| WP:WP1495 | 0.0186595012434 | 0.5 | MTHFR | Glycine metabolism |
| WP:WP5277 | 0.0310970405539 | 0.5 | HSD3B2 | Steroid hormone precursor biosynthesis |
| KEGG:00670 | 0.0356198329076 | 0.5 | MTHFR | One carbon pool by folate |
| WP:WP4873 | 0.0373151717536 | 0.5 | HSD3B2 | Peroxiredoxin 2 induced ovarian failure |
| WP:WP1589 | 0.0435328773163 | 0.5 | MTHFR | Folate alcohol and cancer pathway hypotheses |
| WP:WP496 | 0.0435328773163 | 0.5 | HSD3B2 | Steroid biosynthesis |
| HP:0000834 | 0.0490927251387 | 1.0 | MTHFR HSD3B2 | Abnormality of the adrenal glands |
| WP:WP4524 | 0.049750157242 | 0.5 | HSD3B2 | Alternative pathway of fetal androgen synthesis |
| WP:WP5320 | 0.049750157242 | 0.5 | HSD3B2 | Male steroid hormones in cardiomyocyte energy metabolism |
| HP:0031078 | 0.0499436884913 | 0.5 | HSD3B2 | Impaired cortisol response to corticotropin releasing hormone stimulation test |
| HP:0033809 | 0.0499436884913 | 0.5 | HSD3B2 | Increased circulating 17 hydroxypregnenolone concentration |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| HSD3B1 | HSD3B2 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MTHFR | HSD3B2 | 0.984 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| HSD3B1 | MTHFR | 0.143 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes