hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01475.1
Complex Portal: CPX-19678
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IDH1 | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (IDH1) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDPc) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) | 5 | UniProt NCBI |
| PGD | 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) | 5 | UniProt NCBI |
| ARHGDIA | Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00480 | 0.000933081380813 | 0.666666666667 | IDH1 PGD | Glutathione metabolism |
| KEGG:01200 | 0.00406958776216 | 0.666666666667 | IDH1 PGD | Carbon metabolism |
| REAC:R-HSA-9759194 | 0.0204048321881 | 0.666666666667 | IDH1 PGD | Nuclear events mediated by NFE2L2 |
| CORUM:404 | 0.0249718442456 | 0.333333333333 | IDH1 | Isocitrate dehydrogenase [NADP], cytoplasmic |
| REAC:R-HSA-9755511 | 0.0363497159339 | 0.666666666667 | IDH1 PGD | KEAP1-NFE2L2 pathway |
| REAC:R-HSA-2978092 | 0.0498224659464 | 0.333333333333 | IDH1 | Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate |
| REAC:R-HSA-389542 | 0.0498224659464 | 0.333333333333 | IDH1 | NADPH regeneration |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| IDH1 | PGD | 0.991 | 0.386 | bioplex_WMM Guru bioplex3_WMM gupta_WMM fraction boldt_WMM treiber_WMM | |
| IDH1 | ARHGDIA | 0.959 | 0.22 | bioplex_WMM Guru bioplex3_WMM gupta_WMM fraction boldt_WMM treiber_WMM | |
| ARHGDIA | PGD | 0.759 | 0.198 | bioplex_WMM Guru bioplex3_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
Related Complexes