hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01476.1
Complex Portal: CPX-19845
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SYTL2 | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | 5 | UniProt NCBI |
| SYTL1 | Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) | 5 | UniProt NCBI |
| RPH3AL | Rab effector Noc2 (No C2 domains protein) (Rabphilin-3A-like protein) | 5 | UniProt NCBI |
| MLPH | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | 5 | UniProt NCBI |
| SYTL3 | Synaptotagmin-like protein 3 (Exophilin-6) | 4 | UniProt NCBI |
| RAB27B | Ras-related protein Rab-27B (EC 3.6.5.2) (C25KG) | 5 | UniProt NCBI |
| SYTL4 | Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin) | 5 | UniProt NCBI |
| RAB27A | Ras-related protein Rab-27A (Rab-27) (EC 3.6.5.2) (GTP-binding protein Ram) | 5 | UniProt NCBI |
| SYTL5 | Synaptotagmin-like protein 5 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2291 | 5.46055963966e-27 | 1.0 | SYTL5 SYTL1 RAB27A RAB27B SYTL4 SYTL2 SYTL3 MLPH RPH3AL | Deregulation of Rab and Rab effector genes in bladder cancer |
| GO:0042043 | 8.97131849916e-10 | 0.555555555556 | SYTL5 SYTL1 SYTL4 SYTL2 SYTL3 | neurexin family protein binding |
| GO:0006887 | 1.23789814005e-09 | 0.888888888889 | SYTL5 SYTL3 SYTL1 RAB27A SYTL2 SYTL4 RAB27B RPH3AL | exocytosis |
| GO:0070382 | 5.30915533768e-09 | 0.777777777778 | SYTL3 SYTL1 RAB27A SYTL2 SYTL4 RAB27B SYTL5 | exocytic vesicle |
| GO:0032940 | 4.18504887929e-07 | 0.888888888889 | SYTL5 SYTL3 SYTL1 RAB27A SYTL2 SYTL4 RAB27B RPH3AL | secretion by cell |
| GO:0030133 | 7.29058254534e-07 | 0.777777777778 | SYTL3 SYTL1 RAB27A SYTL2 SYTL4 RAB27B SYTL5 | transport vesicle |
| GO:0046903 | 8.81227954729e-07 | 0.888888888889 | SYTL5 SYTL3 SYTL1 RAB27A SYTL2 SYTL4 RAB27B RPH3AL | secretion |
| GO:0140352 | 9.09453004561e-07 | 0.888888888889 | SYTL5 SYTL3 SYTL1 RAB27A SYTL2 SYTL4 RAB27B RPH3AL | export from cell |
| GO:0042470 | 4.16991368105e-05 | 0.444444444444 | SYTL1 SYTL2 RAB27A RAB27B | melanosome |
| GO:0048770 | 4.16991368105e-05 | 0.444444444444 | SYTL1 SYTL2 RAB27A RAB27B | pigment granule |
| CORUM:6307 | 8.20609246787e-05 | 0.222222222222 | SYTL3 RAB27A | RAB27A-SLP3-KLC1 transport complex |
| GO:0016192 | 0.000416452857451 | 0.888888888889 | SYTL5 SYTL3 SYTL1 RAB27A SYTL2 SYTL4 RAB27B RPH3AL | vesicle-mediated transport |
| HP:0002220 | 0.000919082356402 | 0.222222222222 | MLPH RAB27A | Melanin pigment aggregation in hair shafts |
| GO:0099503 | 0.00145860766152 | 0.777777777778 | SYTL3 SYTL1 RAB27A SYTL2 SYTL4 RAB27B SYTL5 | secretory vesicle |
| HP:0002218 | 0.00306165140522 | 0.222222222222 | MLPH RAB27A | Silver-gray hair |
| REAC:R-HSA-9007101 | 0.00756314206499 | 0.333333333333 | SYTL1 RAB27B RAB27A | Rab regulation of trafficking |
| HP:0007443 | 0.00856441317229 | 0.222222222222 | MLPH RAB27A | Partial albinism |
| GO:0006810 | 0.0155634227783 | 1.0 | SYTL5 SYTL1 RAB27A RAB27B SYTL4 SYTL2 SYTL3 MLPH RPH3AL | transport |
| GO:0017157 | 0.0310808183133 | 0.444444444444 | SYTL4 RPH3AL RAB27A RAB27B | regulation of exocytosis |
| GO:0051234 | 0.0353624737849 | 1.0 | SYTL5 SYTL1 RAB27A RAB27B SYTL4 SYTL2 SYTL3 MLPH RPH3AL | establishment of localization |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SYTL1 | RAB27B | 1.0 | 0.122 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SYTL2 | RAB27B | 0.999 | 0.118 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RPH3AL | RAB27A | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RAB27B | SYTL4 | 0.999 | 0.31 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RAB27B | SYTL5 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| SYTL3 | RAB27A | 0.998 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RAB27A | SYTL5 | 0.998 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SYTL4 | RAB27A | 0.997 | 0.212 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SYTL1 | RAB27A | 0.995 | 0.08 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SYTL2 | RAB27A | 0.995 | 0.074 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RPH3AL | RAB27B | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SYTL3 | RAB27B | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MLPH | RAB27A | 0.985 | 0.05 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RAB27B | RAB27A | 0.973 | 0.37 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MLPH | RAB27B | 0.968 | 0.156 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SYTL2 | SYTL1 | 0.913 | 0.124 | bioplex_WMM bioplex3_WMM WMM_only | |
| SYTL2 | SYTL5 | 0.907 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SYTL2 | RPH3AL | 0.907 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SYTL2 | SYTL3 | 0.907 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SYTL1 | SYTL5 | 0.907 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SYTL3 | SYTL5 | 0.907 | bioplex_WMM bioplex3_WMM WMM_only | ||
| RPH3AL | SYTL5 | 0.907 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SYTL1 | RPH3AL | 0.907 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SYTL1 | SYTL3 | 0.907 | bioplex_WMM bioplex3_WMM WMM_only | ||
| RPH3AL | SYTL3 | 0.9 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SYTL1 | SYTL4 | 0.872 | 0.108 | bioplex_WMM bioplex3_WMM WMM_only | |
| SYTL2 | SYTL4 | 0.872 | 0.14 | bioplex_WMM bioplex3_WMM WMM_only | |
| RPH3AL | SYTL4 | 0.843 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SYTL3 | SYTL4 | 0.843 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SYTL4 | SYTL5 | 0.683 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MLPH | SYTL5 | 0.656 | bioplex3_WMM WMM_only | ||
| RPH3AL | MLPH | 0.64 | bioplex3_WMM WMM_only | ||
| MLPH | SYTL3 | 0.64 | bioplex3_WMM WMM_only | ||
| MLPH | SYTL4 | 0.633 | 0.172 | bioplex3_WMM WMM_only | |
| SYTL1 | MLPH | 0.578 | 0.134 | bioplex3_WMM WMM_only | |
| SYTL2 | MLPH | 0.578 | 0.18 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| SYTL2 | huMAP3_01476.1 huMAP3_14986.1 |
| SYTL1 | huMAP3_01476.1 huMAP3_14986.1 |
| RPH3AL | huMAP3_01476.1 huMAP3_14986.1 |
| MLPH | huMAP3_01476.1 huMAP3_07691.1 huMAP3_12772.1 huMAP3_14986.1 |
| SYTL3 | huMAP3_01476.1 huMAP3_14986.1 |
| RAB27B | huMAP3_01476.1 huMAP3_11660.1 huMAP3_14986.1 |
| SYTL4 | huMAP3_01476.1 huMAP3_11860.1 huMAP3_14986.1 |
| RAB27A | huMAP3_01476.1 huMAP3_14986.1 |
| SYTL5 | huMAP3_01476.1 huMAP3_14986.1 |