hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01486.1
Complex Portal: CPX-25489
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SMPDL3B | Acid sphingomyelinase-like phosphodiesterase 3b (ASM-like phosphodiesterase 3b) (EC 3.1.4.-) | 5 | UniProt NCBI |
| RGS12 | Regulator of G-protein signaling 12 (RGS12) | 5 | UniProt NCBI |
| RGS14 | Regulator of G-protein signaling 14 (RGS14) | 5 | UniProt NCBI |
| GNG11 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 | 5 | UniProt NCBI |
| GNAI3 | Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-418594 | 2.04162706146e-05 | 0.8 | RGS12 GNG11 GNAI3 RGS14 | G alpha (i) signalling events |
| WP:WP536 | 0.000272151633458 | 0.6 | RGS14 GNAI3 GNG11 | Calcium regulation in cardiac cells |
| REAC:R-HSA-388396 | 0.000311311377346 | 0.8 | RGS12 GNG11 GNAI3 RGS14 | GPCR downstream signalling |
| REAC:R-HSA-372790 | 0.000523441642203 | 0.8 | RGS12 GNG11 GNAI3 RGS14 | Signaling by GPCR |
| REAC:R-HSA-392170 | 0.00288114202251 | 0.4 | GNG11 GNAI3 | ADP signalling through P2Y purinoceptor 12 |
| REAC:R-HSA-392518 | 0.0065872694687 | 0.4 | GNG11 GNAI3 | Signal amplification |
| REAC:R-HSA-991365 | 0.00799229651072 | 0.4 | GNG11 GNAI3 | Activation of GABAB receptors |
| REAC:R-HSA-977444 | 0.00799229651072 | 0.4 | GNG11 GNAI3 | GABA B receptor activation |
| REAC:R-HSA-9660821 | 0.00900400267976 | 0.4 | GNG11 GNAI3 | ADORA2B mediated anti-inflammatory cytokines production |
| REAC:R-HSA-418597 | 0.00900400267976 | 0.4 | GNG11 GNAI3 | G alpha (z) signalling events |
| REAC:R-HSA-9634597 | 0.00953234360475 | 0.4 | GNG11 GNAI3 | GPER1 signaling |
| KEGG:04727 | 0.00996128881886 | 0.4 | GNG11 GNAI3 | GABAergic synapse |
| KEGG:05032 | 0.0102617382696 | 0.4 | GNG11 GNAI3 | Morphine addiction |
| KEGG:04713 | 0.0118302702264 | 0.4 | GNG11 GNAI3 | Circadian entrainment |
| REAC:R-HSA-977443 | 0.0123986787504 | 0.4 | GNG11 GNAI3 | GABA receptor activation |
| KEGG:04724 | 0.0145692619713 | 0.4 | GNG11 GNAI3 | Glutamatergic synapse |
| KEGG:04726 | 0.0156689936932 | 0.4 | GNG11 GNAI3 | Serotonergic synapse |
| WP:WP35 | 0.0174803785097 | 0.4 | GNG11 GNAI3 | G protein signaling pathways |
| KEGG:04725 | 0.0175896959812 | 0.4 | GNG11 GNAI3 | Cholinergic synapse |
| GO:0003924 | 0.0180995584082 | 0.8 | RGS12 GNG11 GNAI3 RGS14 | GTPase activity |
| KEGG:04926 | 0.0258857078716 | 0.4 | GNG11 GNAI3 | Relaxin signaling pathway |
| KEGG:04728 | 0.0263659307172 | 0.4 | GNG11 GNAI3 | Dopaminergic synapse |
| WP:WP5380 | 0.0264781270697 | 0.4 | RGS14 GNAI3 | 5q35 copy number variation |
| KEGG:04371 | 0.0273394134018 | 0.4 | GNG11 GNAI3 | Apelin signaling pathway |
| REAC:R-HSA-9664433 | 0.0285103583123 | 0.4 | GNG11 GNAI3 | Leishmania parasite growth and survival |
| REAC:R-HSA-9009391 | 0.0285103583123 | 0.4 | GNG11 GNAI3 | Extra-nuclear estrogen signaling |
| REAC:R-HSA-9662851 | 0.0285103583123 | 0.4 | GNG11 GNAI3 | Anti-inflammatory response favouring Leishmania parasite infection |
| KEGG:04723 | 0.0314069031448 | 0.4 | GNG11 GNAI3 | Retrograde endocannabinoid signaling |
| WP:WP3929 | 0.0420114386662 | 0.4 | GNG11 GNAI3 | Chemokine signaling pathway |
| KEGG:04062 | 0.0427854405203 | 0.4 | GNG11 GNAI3 | Chemokine signaling pathway |
| REAC:R-HSA-111885 | 0.0451765626421 | 0.4 | GNG11 GNAI3 | Opioid Signalling |
| KEGG:05034 | 0.0491193697999 | 0.4 | GNG11 GNAI3 | Alcoholism |
| WP:WP289 | 0.0492060648012 | 0.4 | RGS14 GNG11 | Myometrial relaxation and contraction pathways |
| CORUM:7201 | 0.0498708842806 | 0.2 | GNG11 | GNAS-L-GNB3-GNG11 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RGS12 | GNAI3 | 0.998 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GNG11 | GNAI3 | 0.987 | 0.156 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RGS14 | GNAI3 | 0.968 | 0.096 |
mutually_exclusive (P63096)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SMPDL3B | GNAI3 | 0.964 | 0.108 | bioplex_WMM bioplex3_WMM WMM_only | |
| RGS14 | GNG11 | 0.825 | 0.092 |
mutually_exclusive (P08754)
|
bioplex_WMM bioplex3_WMM WMM_only |
| RGS14 | RGS12 | 0.476 | 0.08 | bioplex_WMM bioplex3_WMM WMM_only | |
| RGS12 | GNG11 | 0.367 | 0.114 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes