hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01514.1
Complex Portal: CPX-22261
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| VPS37B | Vacuolar protein sorting-associated protein 37B (hVps37B) (ESCRT-I complex subunit VPS37B) | 5 | UniProt NCBI |
| PDCD6IP | Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95) | 5 | UniProt NCBI |
| TSG101 | Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) | 5 | UniProt NCBI |
| UMAD1 | UBAP1-MVB12-associated (UMA)-domain containing protein 1 (RPA3 antisense RNA 1) (RPA3 opposite strand) | 2 | UniProt NCBI |
| MVB12A | Multivesicular body subunit 12A (CIN85/CD2AP family-binding protein) (ESCRT-I complex subunit MVB12A) (Protein FAM125A) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-162588 | 7.4870963414e-09 | 0.8 | VPS37B MVB12A PDCD6IP TSG101 | Budding and maturation of HIV virion |
| GO:0039702 | 6.36865069892e-07 | 0.8 | VPS37B MVB12A PDCD6IP TSG101 | viral budding via host ESCRT complex |
| REAC:R-HSA-174490 | 1.13468173222e-06 | 0.6 | VPS37B MVB12A TSG101 | Membrane binding and targetting of GAG proteins |
| REAC:R-HSA-174495 | 1.13468173222e-06 | 0.6 | VPS37B MVB12A TSG101 | Synthesis And Processing Of GAG, GAGPOL Polyproteins |
| GO:0046755 | 1.16377978294e-06 | 0.8 | VPS37B MVB12A PDCD6IP TSG101 | viral budding |
| REAC:R-HSA-175474 | 1.74530562074e-06 | 0.6 | VPS37B MVB12A TSG101 | Assembly Of The HIV Virion |
| GO:0036258 | 4.13351489328e-06 | 0.8 | VPS37B MVB12A PDCD6IP TSG101 | multivesicular body assembly |
| GO:0019068 | 4.72375798258e-06 | 0.8 | VPS37B MVB12A PDCD6IP TSG101 | virion assembly |
| GO:0036257 | 4.72375798258e-06 | 0.8 | VPS37B MVB12A PDCD6IP TSG101 | multivesicular body organization |
| REAC:R-HSA-162599 | 4.81850742601e-06 | 0.8 | VPS37B MVB12A PDCD6IP TSG101 | Late Phase of HIV Life Cycle |
| REAC:R-HSA-162587 | 6.88222150819e-06 | 0.8 | VPS37B MVB12A PDCD6IP TSG101 | HIV Life Cycle |
| REAC:R-HSA-917729 | 1.26352756558e-05 | 0.6 | VPS37B MVB12A TSG101 | Endosomal Sorting Complex Required For Transport (ESCRT) |
| KEGG:04144 | 1.45802271707e-05 | 0.8 | VPS37B MVB12A PDCD6IP TSG101 | Endocytosis |
| REAC:R-HSA-9615710 | 1.54330255969e-05 | 0.6 | VPS37B MVB12A TSG101 | Late endosomal microautophagy |
| REAC:R-HSA-162906 | 4.08222495217e-05 | 0.8 | VPS37B MVB12A PDCD6IP TSG101 | HIV Infection |
| CORUM:1863 | 4.09448956317e-05 | 0.4 | VPS37B TSG101 | TSG101-VPS37B-VPS28 complex |
| GO:0000813 | 0.000115261178119 | 0.6 | VPS37B MVB12A TSG101 | ESCRT I complex |
| WP:WP4932 | 0.000170890043196 | 0.6 | VPS37B MVB12A TSG101 | 7q11 23 copy number variation syndrome |
| GO:0007032 | 0.000217964056115 | 0.8 | VPS37B MVB12A PDCD6IP TSG101 | endosome organization |
| REAC:R-HSA-9610379 | 0.000484679960429 | 0.6 | VPS37B MVB12A TSG101 | HCMV Late Events |
| GO:0043328 | 0.000537554131189 | 0.6 | VPS37B MVB12A TSG101 | protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| REAC:R-HSA-9612973 | 0.00140702215103 | 0.6 | VPS37B MVB12A TSG101 | Autophagy |
| REAC:R-HSA-9609646 | 0.00143724099843 | 0.6 | VPS37B MVB12A TSG101 | HCMV Infection |
| GO:0032511 | 0.00147736290187 | 0.6 | VPS37B MVB12A TSG101 | late endosome to vacuole transport via multivesicular body sorting pathway |
| GO:0036452 | 0.00220577099344 | 0.6 | VPS37B MVB12A TSG101 | ESCRT complex |
| REAC:R-HSA-9824446 | 0.00414507922686 | 0.8 | VPS37B MVB12A PDCD6IP TSG101 | Viral Infection Pathways |
| GO:0045324 | 0.00430818612204 | 0.6 | VPS37B MVB12A TSG101 | late endosome to vacuole transport |
| GO:0043162 | 0.00522817157061 | 0.6 | VPS37B MVB12A TSG101 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| GO:0032509 | 0.00573353417253 | 0.6 | VPS37B MVB12A TSG101 | endosome transport via multivesicular body sorting pathway |
| HPA:0550053 | 0.00672899761151 | 1.0 | VPS37B UMAD1 PDCD6IP MVB12A TSG101 | stomach 2; glandular cells[High] |
| HPA:0540053 | 0.00691444355796 | 1.0 | VPS37B UMAD1 PDCD6IP MVB12A TSG101 | stomach 1; glandular cells[High] |
| KEGG:03250 | 0.00720037844657 | 0.4 | TSG101 PDCD6IP | Viral life cycle - HIV-1 |
| REAC:R-HSA-5663205 | 0.00938555933211 | 0.8 | VPS37B MVB12A PDCD6IP TSG101 | Infectious disease |
| GO:0071985 | 0.0094606249379 | 0.6 | VPS37B MVB12A TSG101 | multivesicular body sorting pathway |
| GO:0090148 | 0.0102064666638 | 0.6 | VPS37B MVB12A TSG101 | membrane fission |
| GO:0019058 | 0.0104396043736 | 0.8 | VPS37B MVB12A PDCD6IP TSG101 | viral life cycle |
| GO:1903772 | 0.0140440992017 | 0.4 | VPS37B TSG101 | regulation of viral budding via host ESCRT complex |
| GO:1903774 | 0.0140440992017 | 0.4 | VPS37B TSG101 | positive regulation of viral budding via host ESCRT complex |
| HPA:0220053 | 0.0150367168508 | 1.0 | VPS37B UMAD1 PDCD6IP MVB12A TSG101 | gallbladder; glandular cells[High] |
| GO:0072666 | 0.0224016609185 | 0.6 | VPS37B MVB12A TSG101 | establishment of protein localization to vacuole |
| GO:0048306 | 0.0279690439474 | 0.6 | VPS37B PDCD6IP TSG101 | calcium-dependent protein binding |
| GO:0016236 | 0.029345634756 | 0.8 | VPS37B MVB12A PDCD6IP TSG101 | macroautophagy |
| GO:0016050 | 0.0329457298686 | 0.8 | VPS37B MVB12A PDCD6IP TSG101 | vesicle organization |
| GO:0016032 | 0.0488196060798 | 0.8 | VPS37B MVB12A PDCD6IP TSG101 | viral process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TSG101 | MVB12A | 1.0 | 0.366 | hein_WMM bioplex_WMM bioplex3_WMM hein () Malo fraction | |
| VPS37B | TSG101 | 1.0 | 0.252 | hein_WMM bioplex_WMM Guru bioplex3_WMM youn_WMM hein () Malo fraction | |
| PDCD6IP | MVB12A | 0.997 | 0.118 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| VPS37B | MVB12A | 0.997 | 0.268 | hein_WMM bioplex_WMM bioplex3_WMM Malo fraction | |
| TSG101 | UMAD1 | 0.988 | 0.154 | hein_WMM bioplex3_WMM WMM_only | |
| PDCD6IP | TSG101 | 0.982 | 0.246666666667 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| UMAD1 | MVB12A | 0.981 | 0.054 | hein_WMM bioplex3_WMM WMM_only | |
| PDCD6IP | UMAD1 | 0.963 | 0.096 | hein_WMM bioplex3_WMM WMM_only | |
| VPS37B | UMAD1 | 0.844 | 0.062 | hein_WMM bioplex3_WMM WMM_only | |
| VPS37B | PDCD6IP | 0.01 | 0.11 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes