hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_01525.1

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
RBM43	RNA-binding protein 43 (RNA-binding motif protein 43)	2	UniProt NCBI
PHF3	PHD finger protein 3	3	UniProt NCBI
MAPKAPK2	MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1)	5	UniProt NCBI
MAPKAPK3	MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK)	5	UniProt NCBI
MAPK11	Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2)	5	UniProt NCBI
RSRC2	Arginine/serine-rich coiled-coil protein 2	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-171007	8.4720413934e-07	0.5	MAPKAPK2 MAPKAPK3 MAPK11	p38MAPK events
REAC:R-HSA-167044	2.56826946848e-06	0.5	MAPKAPK2 MAPKAPK3 MAPK11	Signalling to RAS
REAC:R-HSA-450302	8.03604834368e-06	0.5	MAPKAPK2 MAPKAPK3 MAPK11	activated TAK1 mediates p38 MAPK activation
REAC:R-HSA-187687	1.83108883385e-05	0.5	MAPKAPK2 MAPKAPK3 MAPK11	Signalling to ERKs
KEGG:04370	4.11375354214e-05	0.5	MAPKAPK2 MAPKAPK3 MAPK11	VEGF signaling pathway
REAC:R-HSA-450294	0.000194320923954	0.5	MAPKAPK2 MAPKAPK3 MAPK11	MAP kinase activation
REAC:R-HSA-448424	0.000264877822759	0.5	MAPKAPK2 MAPKAPK3 MAPK11	Interleukin-17 signaling
REAC:R-HSA-168176	0.000618329565809	0.5	MAPKAPK2 MAPKAPK3 MAPK11	Toll Like Receptor 5 (TLR5) Cascade
REAC:R-HSA-975871	0.000618329565809	0.5	MAPKAPK2 MAPKAPK3 MAPK11	MyD88 cascade initiated on plasma membrane
REAC:R-HSA-168142	0.000618329565809	0.5	MAPKAPK2 MAPKAPK3 MAPK11	Toll Like Receptor 10 (TLR10) Cascade
REAC:R-HSA-975138	0.000665071217307	0.5	MAPKAPK2 MAPKAPK3 MAPK11	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REAC:R-HSA-975155	0.000689296551176	0.5	MAPKAPK2 MAPKAPK3 MAPK11	MyD88 dependent cascade initiated on endosome
REAC:R-HSA-168181	0.000689296551176	0.5	MAPKAPK2 MAPKAPK3 MAPK11	Toll Like Receptor 7/8 (TLR7/8) Cascade
REAC:R-HSA-4420097	0.00073948978705	0.5	MAPKAPK2 MAPKAPK3 MAPK11	VEGFA-VEGFR2 Pathway
REAC:R-HSA-168138	0.000792051133325	0.5	MAPKAPK2 MAPKAPK3 MAPK11	Toll Like Receptor 9 (TLR9) Cascade
REAC:R-HSA-168164	0.00084703415394	0.5	MAPKAPK2 MAPKAPK3 MAPK11	Toll Like Receptor 3 (TLR3) Cascade
REAC:R-HSA-937061	0.00090449234483	0.5	MAPKAPK2 MAPKAPK3 MAPK11	TRIF(TICAM1)-mediated TLR4 signaling
REAC:R-HSA-166166	0.00090449234483	0.5	MAPKAPK2 MAPKAPK3 MAPK11	MyD88-independent TLR4 cascade
REAC:R-HSA-194138	0.000964479133971	0.5	MAPKAPK2 MAPKAPK3 MAPK11	Signaling by VEGF
REAC:R-HSA-168188	0.000964479133971	0.5	MAPKAPK2 MAPKAPK3 MAPK11	Toll Like Receptor TLR6:TLR2 Cascade
REAC:R-HSA-166058	0.000964479133971	0.5	MAPKAPK2 MAPKAPK3 MAPK11	MyD88:MAL(TIRAP) cascade initiated on plasma membrane
REAC:R-HSA-168179	0.00102704788141	0.5	MAPKAPK2 MAPKAPK3 MAPK11	Toll Like Receptor TLR1:TLR2 Cascade
REAC:R-HSA-181438	0.00102704788141	0.5	MAPKAPK2 MAPKAPK3 MAPK11	Toll Like Receptor 2 (TLR2) Cascade
REAC:R-HSA-187037	0.00102704788141	0.5	MAPKAPK2 MAPKAPK3 MAPK11	Signaling by NTRK1 (TRKA)
REAC:R-HSA-2559580	0.00138048384488	0.5	MAPKAPK2 MAPKAPK3 MAPK11	Oxidative Stress Induced Senescence
REAC:R-HSA-166520	0.00167064168535	0.5	MAPKAPK2 MAPKAPK3 MAPK11	Signaling by NTRKs
REAC:R-HSA-166016	0.00209955523641	0.5	MAPKAPK2 MAPKAPK3 MAPK11	Toll Like Receptor 4 (TLR4) Cascade
REAC:R-HSA-168898	0.00323172543915	0.5	MAPKAPK2 MAPKAPK3 MAPK11	Toll-like Receptor Cascades
WP:WP722	0.00326040131097	0.333333333333	MAPKAPK2 MAPKAPK3	Serotonin HTR1 group and FOS pathway
WP:WP382	0.00356647092307	0.5	MAPKAPK2 MAPKAPK3 MAPK11	MAPK signaling pathway
KEGG:04010	0.00452915785835	0.5	MAPKAPK2 MAPKAPK3 MAPK11	MAPK signaling pathway
REAC:R-HSA-2559583	0.00604240808777	0.5	MAPKAPK2 MAPKAPK3 MAPK11	Cellular Senescence
WP:WP314	0.00703705758996	0.333333333333	MAPKAPK2 MAPKAPK3	Fas ligand pathway and stress induction of heat shock proteins
WP:WP2637	0.00903081201495	0.333333333333	MAPKAPK2 MAPK11	Interleukin 1 IL 1 structural pathway
REAC:R-HSA-450282	0.0111743831709	0.333333333333	MAPKAPK2 MAPK11	MAPK targets/ Nuclear events mediated by MAP kinases
KEGG:04625	0.0255639626352	0.333333333333	MAPKAPK2 MAPK11	C-type lectin receptor signaling pathway
KEGG:04722	0.0353486809432	0.333333333333	MAPKAPK2 MAPK11	Neurotrophin signaling pathway
REAC:R-HSA-198725	0.03659902859	0.333333333333	MAPKAPK2 MAPK11	Nuclear Events (kinase and transcription factor activation)

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
MAPKAPK2	MAPK11	0.999		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
MAPKAPK3	MAPK11	0.998		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
MAPKAPK2	MAPKAPK3	0.997	0.226	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
PHF3	MAPKAPK2	0.995	0.048	bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
RBM43	MAPKAPK2	0.986		bioplex3_HEK293 bioplex3_WMM WMM_only
MAPKAPK2	RSRC2	0.979	0.018	bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
PHF3	MAPKAPK3	0.675	0.09	bioplex3_WMM WMM_only
PHF3	MAPK11	0.675		bioplex3_WMM WMM_only
PHF3	RSRC2	0.649	0.072	bioplex3_WMM youn_WMM WMM_only
MAPK11	RSRC2	0.364		bioplex3_WMM WMM_only
MAPKAPK3	RSRC2	0.343	0.04	bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
RBM43	huMAP3_00126.1 huMAP3_01525.1 huMAP3_02080.1 huMAP3_10583.1 huMAP3_15205.1
PHF3	huMAP3_01525.1 huMAP3_03952.1 huMAP3_07778.1 huMAP3_07964.1 huMAP3_08407.1 huMAP3_10583.1 huMAP3_11018.1 huMAP3_11848.1
MAPKAPK2	huMAP3_01525.1 huMAP3_04030.1 huMAP3_05536.1 huMAP3_07206.1 huMAP3_07964.1 huMAP3_08407.1 huMAP3_10074.1 huMAP3_10583.1 huMAP3_11114.1 huMAP3_11371.1 huMAP3_11575.1 huMAP3_14776.1 huMAP3_15022.1
MAPKAPK3	huMAP3_01525.1 huMAP3_04030.1 huMAP3_05402.1 huMAP3_06585.1 huMAP3_07936.1 huMAP3_08407.1 huMAP3_10997.1 huMAP3_12751.1 huMAP3_14776.1
MAPK11	huMAP3_01525.1 huMAP3_04030.1 huMAP3_05402.1 huMAP3_06585.1 huMAP3_07206.1 huMAP3_07936.1 huMAP3_08407.1 huMAP3_10997.1 huMAP3_12751.1 huMAP3_14776.1
RSRC2	huMAP3_01525.1 huMAP3_05536.1 huMAP3_07703.1 huMAP3_08042.1 huMAP3_08290.1 huMAP3_10074.1 huMAP3_10583.1 huMAP3_11575.1 huMAP3_13273.1 huMAP3_15022.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_01525.1