hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01529.1
Complex Portal: CPX-18607
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LEO1 | RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) | 5 | UniProt NCBI |
| SKIC8 | Superkiller complex protein 8 (Ski8) (Meiotic recombination REC14 protein homolog) (WD repeat-containing protein 61) [Cleaved into: Superkiller complex protein 8, N-terminally processed (WD repeat-containing protein 61, N-terminally processed)] | 5 | UniProt NCBI |
| PAF1 | RNA polymerase II-associated factor 1 homolog (hPAF1) (Pancreatic differentiation protein 2) | 5 | UniProt NCBI |
| TTC33 | Tetratricopeptide repeat protein 33 (TPR repeat protein 33) (Osmosis-responsive factor) | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1167 | 7.01534115619e-09 | 0.75 | LEO1 SKIC8 PAF1 | Paf complex |
| GO:0016593 | 1.34540429244e-05 | 0.75 | LEO1 SKIC8 PAF1 | Cdc73/Paf1 complex |
| REAC:R-HSA-8866654 | 3.47141671819e-05 | 0.75 | LEO1 SKIC8 PAF1 | E3 ubiquitin ligases ubiquitinate target proteins |
| REAC:R-HSA-112382 | 4.09441910601e-05 | 0.75 | LEO1 SKIC8 PAF1 | Formation of RNA Pol II elongation complex |
| REAC:R-HSA-75955 | 4.09441910601e-05 | 0.75 | LEO1 SKIC8 PAF1 | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-8852135 | 9.06303437184e-05 | 0.75 | LEO1 SKIC8 PAF1 | Protein ubiquitination |
| REAC:R-HSA-674695 | 0.000110531761496 | 0.75 | LEO1 SKIC8 PAF1 | RNA Polymerase II Pre-transcription Events |
| GO:0008023 | 0.00622026610693 | 0.75 | LEO1 SKIC8 PAF1 | transcription elongation factor complex |
| GO:0045638 | 0.0152210712647 | 0.75 | LEO1 SKIC8 PAF1 | negative regulation of myeloid cell differentiation |
| WP:WP2853 | 0.0165681999049 | 0.5 | LEO1 PAF1 | Endoderm differentiation |
| GO:0016591 | 0.0192043220783 | 0.75 | LEO1 SKIC8 PAF1 | RNA polymerase II, holoenzyme |
| GO:0031442 | 0.042122686785 | 0.5 | LEO1 PAF1 | positive regulation of mRNA 3'-end processing |
| GO:0055029 | 0.048062454325 | 0.75 | LEO1 SKIC8 PAF1 | nuclear DNA-directed RNA polymerase complex |
| GO:0000428 | 0.0496619752722 | 0.75 | LEO1 SKIC8 PAF1 | DNA-directed RNA polymerase complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SKIC8 | LEO1 | 1.0 | 0.186 | hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 fraction boldt_WMM | |
| LEO1 | PAF1 | 1.0 | 0.95 | hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 fraction boldt_WMM | |
| SKIC8 | PAF1 | 1.0 | 0.264 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 fraction boldt_WMM |
| SKIC8 | TTC33 | 0.993 | 0.182 |
mutually_exclusive (Q7RTV0)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| LEO1 | TTC33 | 0.501 | 0.078 | bioplex3_WMM WMM_only | |
| PAF1 | TTC33 | 0.457 | 0.146 |
mutually_exclusive (Q9GZS3)
|
bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes