hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01538.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| VMA21 | Vacuolar ATPase assembly integral membrane protein VMA21 (Myopathy with excessive autophagy protein) | 5 | UniProt NCBI |
| ATP6V0E1 | V-type proton ATPase subunit e 1 (V-ATPase subunit e 1) (V-ATPase 9.2 kDa membrane accessory protein) (V-ATPase M9.2 subunit) (Vacuolar proton pump subunit e 1) | 5 | UniProt NCBI |
| TMEM199 | Transmembrane protein 199 | 5 | UniProt NCBI |
| ATP6V0A4 | V-type proton ATPase 116 kDa subunit a 4 (V-ATPase 116 kDa isoform a 4) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4) (Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform) | 5 | UniProt NCBI |
| CCDC115 | Coiled-coil domain-containing protein 115 | 5 | UniProt NCBI |
| SLC14A1 | Urea transporter 1 (Solute carrier family 14 member 1) (Urea transporter, erythrocyte) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0007035 | 8.06004189332e-06 | 0.666666666667 | CCDC115 ATP6V0E1 TMEM199 ATP6V0A4 | vacuolar acidification |
| GO:0051452 | 3.98084194662e-05 | 0.666666666667 | CCDC115 ATP6V0E1 TMEM199 ATP6V0A4 | intracellular pH reduction |
| GO:0051453 | 0.000191285986513 | 0.666666666667 | CCDC115 ATP6V0E1 TMEM199 ATP6V0A4 | regulation of intracellular pH |
| GO:0030641 | 0.000218779399595 | 0.666666666667 | CCDC115 ATP6V0E1 TMEM199 ATP6V0A4 | regulation of cellular pH |
| GO:0006885 | 0.000265438603659 | 0.666666666667 | CCDC115 ATP6V0E1 TMEM199 ATP6V0A4 | regulation of pH |
| KEGG:04966 | 0.00183232201518 | 0.333333333333 | ATP6V0E1 ATP6V0A4 | Collecting duct acid secretion |
| GO:0016471 | 0.00295184433846 | 0.5 | ATP6V0A4 TMEM199 CCDC115 | vacuolar proton-transporting V-type ATPase complex |
| GO:0033176 | 0.00339409783315 | 0.5 | ATP6V0A4 TMEM199 CCDC115 | proton-transporting V-type ATPase complex |
| HP:0010837 | 0.00388470114881 | 0.333333333333 | TMEM199 CCDC115 | Decreased circulating ceruloplasmin concentration |
| HP:0033144 | 0.00593279372985 | 0.333333333333 | TMEM199 CCDC115 | Abnormal circulating ceruloplasmin concentration |
| KEGG:05110 | 0.0071411999113 | 0.333333333333 | ATP6V0E1 ATP6V0A4 | Vibrio cholerae infection |
| WP:WP4917 | 0.00741608411471 | 0.333333333333 | ATP6V0E1 ATP6V0A4 | Proximal tubule transport |
| REAC:R-HSA-77387 | 0.00971370123257 | 0.333333333333 | ATP6V0E1 ATP6V0A4 | Insulin receptor recycling |
| REAC:R-HSA-917977 | 0.00971370123257 | 0.333333333333 | ATP6V0E1 ATP6V0A4 | Transferrin endocytosis and recycling |
| REAC:R-HSA-1222556 | 0.0119428487471 | 0.333333333333 | ATP6V0E1 ATP6V0A4 | ROS and RNS production in phagocytes |
| KEGG:04721 | 0.0127326461903 | 0.333333333333 | ATP6V0E1 ATP6V0A4 | Synaptic vesicle cycle |
| KEGG:05120 | 0.0140413695312 | 0.333333333333 | ATP6V0E1 ATP6V0A4 | Epithelial cell signaling in Helicobacter pylori infection |
| KEGG:05323 | 0.0163630378499 | 0.333333333333 | ATP6V0E1 ATP6V0A4 | Rheumatoid arthritis |
| GO:0016469 | 0.0252998897888 | 0.5 | ATP6V0A4 TMEM199 CCDC115 | proton-transporting two-sector ATPase complex |
| REAC:R-HSA-917937 | 0.0339259639772 | 0.333333333333 | ATP6V0E1 ATP6V0A4 | Iron uptake and transport |
| HP:0003141 | 0.037751561683 | 0.333333333333 | TMEM199 CCDC115 | Increased LDL cholesterol concentration |
| GO:0005773 | 0.0427446223865 | 0.833333333333 | ATP6V0A4 ATP6V0E1 VMA21 CCDC115 TMEM199 | vacuole |
| REAC:R-HSA-74752 | 0.048293243222 | 0.333333333333 | ATP6V0E1 ATP6V0A4 | Signaling by Insulin receptor |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| VMA21 | TMEM199 | 1.0 | 0.04 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| CCDC115 | TMEM199 | 0.999 | 0.458 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| CCDC115 | ATP6V0A4 | 0.997 | 0.138 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| VMA21 | CCDC115 | 0.994 | 0.092 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| VMA21 | ATP6V0A4 | 0.994 | 0.056 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| SLC14A1 | TMEM199 | 0.985 | 0.058 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| SLC14A1 | CCDC115 | 0.981 | 0.092 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| CCDC115 | ATP6V0E1 | 0.972 | bioplex3_HEK293 bioplex () | |
| ATP6V0A4 | TMEM199 | 0.954 | 0.116 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| VMA21 | ATP6V0E1 | 0.91 | bioplex3_HEK293 bioplex () | |
| ATP6V0E1 | TMEM199 | 0.866 | bioplex3_HEK293 bioplex () |
Related Complexes