hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_01565.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| AXIN1 | Axin-1 (Axis inhibition protein 1) (hAxin) | 5 | UniProt NCBI |
| AMER1 | APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5467337 | 0.000155497319444 | 1.0 | AXIN1 AMER1 | APC truncation mutants have impaired AXIN binding |
| REAC:R-HSA-5467348 | 0.000155497319444 | 1.0 | AXIN1 AMER1 | Truncations of AMER1 destabilize the destruction complex |
| REAC:R-HSA-4839735 | 0.000155497319444 | 1.0 | AXIN1 AMER1 | Signaling by AXIN mutants |
| REAC:R-HSA-4839744 | 0.000155497319444 | 1.0 | AXIN1 AMER1 | Signaling by APC mutants |
| REAC:R-HSA-4839748 | 0.000155497319444 | 1.0 | AXIN1 AMER1 | Signaling by AMER1 mutants |
| REAC:R-HSA-5467340 | 0.000155497319444 | 1.0 | AXIN1 AMER1 | AXIN missense mutants destabilize the destruction complex |
| REAC:R-HSA-5358751 | 0.000179419983974 | 1.0 | AXIN1 AMER1 | CTNNB1 S45 mutants aren't phosphorylated |
| REAC:R-HSA-5358752 | 0.000179419983974 | 1.0 | AXIN1 AMER1 | CTNNB1 T41 mutants aren't phosphorylated |
| REAC:R-HSA-5358747 | 0.000179419983974 | 1.0 | AXIN1 AMER1 | CTNNB1 S33 mutants aren't phosphorylated |
| REAC:R-HSA-4839743 | 0.000179419983974 | 1.0 | AXIN1 AMER1 | Signaling by CTNNB1 phospho-site mutants |
| REAC:R-HSA-5339716 | 0.000179419983974 | 1.0 | AXIN1 AMER1 | Signaling by GSK3beta mutants |
| REAC:R-HSA-5358749 | 0.000179419983974 | 1.0 | AXIN1 AMER1 | CTNNB1 S37 mutants aren't phosphorylated |
| REAC:R-HSA-196299 | 0.00023239159829 | 1.0 | AXIN1 AMER1 | Beta-catenin phosphorylation cascade |
| REAC:R-HSA-4641262 | 0.00079457421474 | 1.0 | AXIN1 AMER1 | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| REAC:R-HSA-4791275 | 0.000902226205124 | 1.0 | AXIN1 AMER1 | Signaling by WNT in cancer |
| REAC:R-HSA-195253 | 0.0055363880769 | 1.0 | AXIN1 AMER1 | Degradation of beta-catenin by the destruction complex |
| REAC:R-HSA-201681 | 0.0364325093171 | 1.0 | AXIN1 AMER1 | TCF dependent signaling in response to WNT |
| CORUM:3004 | 0.0499419797295 | 0.5 | AXIN1 | APC-AXIN1-CTNNB1 complex |
| CORUM:2968 | 0.0499419797295 | 0.5 | AXIN1 | Axin-SMAD3 complex |
| CORUM:3168 | 0.0499419797295 | 0.5 | AXIN1 | DAXX-AXIN complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| AXIN1 | AMER1 | 0.966 | 0.062 | hein_WMM hein () |
Related Complexes