hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_01577.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NUDT21 | Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit) (CPSF 25 kDa subunit) (Cleavage factor Im complex 25 kDa subunit) (CFIm25) (Nucleoside diphosphate-linked moiety X motif 21) (Nudix motif 21) (Nudix hydrolase 21) (Pre-mRNA cleavage factor Im 68 kDa subunit) | 5 | UniProt NCBI |
| CRTAP | Cartilage-associated protein | 5 | UniProt NCBI |
| P3H2 | Prolyl 3-hydroxylase 2 (EC 1.14.11.7) (Leprecan-like protein 1) (Myxoid liposarcoma-associated protein 4) | 5 | UniProt NCBI |
| CPSF6 | Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1769 | 1.53774525569e-05 | 0.5 | NUDT21 CPSF6 | CPSF6-ITCH-NUDT21-POLR2A complex |
| CORUM:1767 | 3.07520988333e-05 | 0.5 | NUDT21 CPSF6 | CPSF6-ITCH-NUDT21-POLR2A-UBAP2L complex |
| CORUM:1768 | 5.12488211613e-05 | 0.5 | NUDT21 CPSF6 | CPSF6-EWSR1-ITCH-NUDT21-POLR2A-UBAP2L complex |
| CORUM:1141 | 0.00039944903428 | 0.5 | NUDT21 CPSF6 | CF IIAm complex (Cleavage factor IIAm complex) |
| WP:WP4786 | 0.0011843872874 | 0.5 | CRTAP P3H2 | Type I collagen synthesis in the context of osteogenesis imperfecta |
| GO:1990120 | 0.00842684400117 | 0.5 | NUDT21 CPSF6 | messenger ribonucleoprotein complex assembly |
| KEGG:03015 | 0.0101879335017 | 0.5 | NUDT21 CPSF6 | mRNA surveillance pathway |
| REAC:R-HSA-1650814 | 0.0135329645116 | 0.5 | CRTAP P3H2 | Collagen biosynthesis and modifying enzymes |
| GO:0110104 | 0.0168521501606 | 0.5 | NUDT21 CPSF6 | mRNA alternative polyadenylation |
| REAC:R-HSA-1474290 | 0.0260384914588 | 0.5 | CRTAP P3H2 | Collagen formation |
| CORUM:351 | 0.047170241778 | 0.5 | NUDT21 CPSF6 | Spliceosome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NUDT21 | CPSF6 | 1.0 | 0.892 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| CRTAP | P3H2 | 0.998 | 0.062 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| CPSF6 | CRTAP | 0.977 | 0.094 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM WMM_only |
| NUDT21 | P3H2 | 0.972 | 0.018 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| NUDT21 | CRTAP | 0.961 | 0.088 | hein_WMM bioplex_WMM bioplex3_WMM hein () treiber_WMM |
| CPSF6 | P3H2 | 0.759 | 0.022 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes