hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_01586.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PNKP | Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)] | 5 | UniProt NCBI |
| LIG3 | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | 5 | UniProt NCBI |
| POLB | DNA polymerase beta (EC 2.7.7.7) (5'-deoxyribose-phosphate lyase) (5'-dRP lyase) (EC 4.2.99.-) (AP lyase) (EC 4.2.99.18) | 5 | UniProt NCBI |
| XRCC1 | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | 5 | UniProt NCBI |
| TDP1 | Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5243 | 7.01606139244e-10 | 0.75 | LIG3 PNKP TDP1 | XRCC1-LIG3-PNK-TDP1 complex |
| CORUM:362 | 7.01606139244e-10 | 0.75 | LIG3 PNKP POLB | DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex |
| KEGG:03410 | 2.89932302932e-09 | 1.0 | LIG3 PNKP TDP1 POLB | Base excision repair |
| REAC:R-HSA-5649702 | 4.91023464396e-08 | 0.75 | LIG3 PNKP POLB | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway |
| WP:WP4752 | 1.41711470375e-06 | 0.75 | LIG3 PNKP POLB | Base excision repair |
| REAC:R-HSA-73933 | 9.16893973468e-06 | 0.75 | LIG3 PNKP POLB | Resolution of Abasic Sites (AP sites) |
| CORUM:1086 | 3.07520988333e-05 | 0.5 | LIG3 POLB | DNA repair complex NEIL1-PNK-Pol(beta)-LigIII(alpha)-XRCC1 |
| CORUM:1085 | 3.07520988333e-05 | 0.5 | LIG3 POLB | DNA repair complex NEIL2-PNK-Pol(beta)-LigIII(alpha)-XRCC1 |
| REAC:R-HSA-73894 | 3.4398535169e-05 | 1.0 | LIG3 PNKP TDP1 POLB | DNA Repair |
| REAC:R-HSA-110381 | 6.15041976665e-05 | 0.5 | LIG3 POLB | Resolution of AP sites via the single-nucleotide replacement pathway |
| WP:WP4946 | 8.13748974369e-05 | 0.75 | LIG3 PNKP POLB | DNA repair pathways full network |
| REAC:R-HSA-73884 | 9.82762051365e-05 | 0.75 | LIG3 PNKP POLB | Base Excision Repair |
| HP:0003431 | 0.000106949015958 | 0.75 | LIG3 PNKP TDP1 | Decreased motor nerve conduction velocity |
| GO:0006287 | 0.000109904886398 | 0.75 | LIG3 PNKP POLB | base-excision repair, gap-filling |
| HP:0040131 | 0.000119760892232 | 0.75 | LIG3 PNKP TDP1 | Abnormal motor nerve conduction velocity |
| HP:0007141 | 0.0004188257634 | 0.75 | LIG3 PNKP TDP1 | Sensorimotor neuropathy |
| HP:0000762 | 0.000610673070958 | 0.75 | LIG3 PNKP TDP1 | Decreased nerve conduction velocity |
| HP:0040129 | 0.000692770824976 | 0.75 | LIG3 PNKP TDP1 | Abnormal nerve conduction velocity |
| HP:0003134 | 0.00118368574867 | 0.75 | LIG3 PNKP TDP1 | Abnormality of peripheral nerve conduction |
| HP:0030177 | 0.0020342326718 | 0.75 | LIG3 PNKP TDP1 | Abnormality of peripheral nervous system electrophysiology |
| HP:0032120 | 0.00216847712216 | 0.75 | LIG3 PNKP TDP1 | Abnormal peripheral nervous system physiology |
| GO:0006284 | 0.0037914498893 | 0.75 | LIG3 PNKP POLB | base-excision repair |
| HP:0002460 | 0.00560031090768 | 0.75 | LIG3 PNKP TDP1 | Distal muscle weakness |
| GO:0006302 | 0.00569790407237 | 1.0 | LIG3 PNKP TDP1 POLB | double-strand break repair |
| WP:WP4016 | 0.00742144474402 | 0.5 | POLB TDP1 | DNA IR damage and cellular response via ATR |
| HPA:0570792 | 0.00984917803316 | 1.0 | LIG3 PNKP TDP1 POLB | testis; round or early spermatids[>=Medium] |
| GO:0051103 | 0.0168521501606 | 0.5 | LIG3 PNKP | DNA ligation involved in DNA repair |
| HP:0003690 | 0.0206880734637 | 0.75 | LIG3 PNKP TDP1 | Limb muscle weakness |
| HPA:0570791 | 0.0219426043333 | 1.0 | LIG3 PNKP TDP1 POLB | testis; round or early spermatids[>=Low] |
| CORUM:365 | 0.0249718442456 | 0.25 | LIG3 | DNA ligase III-XRCC1 complex |
| CORUM:363 | 0.0249718442456 | 0.25 | LIG3 | DNA ligase III-XRCC1 complex |
| CORUM:212 | 0.0249718442456 | 0.25 | LIG3 | DNA ligase III-XRCC1 complex |
| HP:0003380 | 0.0259951101914 | 0.5 | LIG3 TDP1 | Decreased number of peripheral myelinated nerve fibers |
| HP:0003474 | 0.0326734499101 | 0.75 | LIG3 PNKP TDP1 | Somatic sensory dysfunction |
| HP:0410008 | 0.0416942448541 | 0.75 | LIG3 PNKP TDP1 | Abnormality of the peripheral nervous system |
| HP:0001272 | 0.0433416366127 | 0.75 | LIG3 PNKP TDP1 | Cerebellar atrophy |
| HPA:0050093 | 0.0447503600593 | 0.75 | LIG3 PNKP POLB | breast; myoepithelial cells[High] |
| CORUM:7352 | 0.049938562206 | 0.25 | LIG3 | PARP1-LIG3 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| LIG3 | XRCC1 | 1.0 | 0.55 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM | |
| POLB | XRCC1 | 0.999 | 0.084 |
mutually_exclusive (P35244)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| LIG3 | POLB | 0.999 | 0.1 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LIG3 | PNKP | 0.998 | 0.18 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LIG3 | TDP1 | 0.996 | 0.0660385964912 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PNKP | POLB | 0.994 | 0.108 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PNKP | XRCC1 | 0.993 | 0.13 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| POLB | TDP1 | 0.986 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| XRCC1 | TDP1 | 0.918 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | |
| PNKP | TDP1 | 0.862 | 0.12 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes