hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01616.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WWTR1 | WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif) | 5 | UniProt NCBI |
| AMOTL2 | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | 5 | UniProt NCBI |
| TEAD2 | Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2) | 5 | UniProt NCBI |
| YAP1 | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8951671 | 7.85597209803e-08 | 0.75 | TEAD2 WWTR1 YAP1 | RUNX3 regulates YAP1-mediated transcription |
| REAC:R-HSA-2032785 | 3.0856409449e-07 | 0.75 | TEAD2 WWTR1 YAP1 | YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| WP:WP4537 | 3.38413923581e-07 | 0.75 | TEAD2 WWTR1 YAP1 | Hippo YAP signaling |
| KEGG:04392 | 8.91489558656e-07 | 0.75 | TEAD2 WWTR1 YAP1 | Hippo signaling pathway - multiple species |
| REAC:R-HSA-2028269 | 1.35859604357e-06 | 0.75 | AMOTL2 WWTR1 YAP1 | Signaling by Hippo |
| GO:0035329 | 2.94517278885e-06 | 1.0 | AMOTL2 YAP1 WWTR1 TEAD2 | hippo signaling |
| WP:WP4534 | 3.44677262663e-06 | 0.75 | TEAD2 WWTR1 YAP1 | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms |
| CORUM:6651 | 5.12628525639e-06 | 0.5 | YAP1 WWTR1 | WWTR1-YAP1 complex |
| WP:WP4540 | 3.08286329452e-05 | 0.75 | TEAD2 WWTR1 YAP1 | Hippo signaling regulation pathways |
| WP:WP4541 | 4.97020885026e-05 | 0.75 | TEAD2 WWTR1 YAP1 | Hippo Merlin signaling dysregulation |
| REAC:R-HSA-8878159 | 0.000153311097908 | 0.75 | TEAD2 WWTR1 YAP1 | Transcriptional regulation by RUNX3 |
| KEGG:04390 | 0.000173136486645 | 0.75 | TEAD2 WWTR1 YAP1 | Hippo signaling pathway |
| WP:WP3967 | 0.000306067313039 | 0.5 | TEAD2 YAP1 | miR 509 3p alteration of YAP1 ECM axis |
| REAC:R-HSA-9796292 | 0.000368856835097 | 0.5 | TEAD2 YAP1 | Formation of axial mesoderm |
| WP:WP4542 | 0.00103429913449 | 0.5 | TEAD2 YAP1 | Leukocyte intrinsic Hippo pathway functions |
| REAC:R-HSA-8940973 | 0.00194479046925 | 0.5 | YAP1 WWTR1 | RUNX2 regulates osteoblast differentiation |
| REAC:R-HSA-9619665 | 0.00214930898727 | 0.5 | YAP1 WWTR1 | EGR2 and SOX10-mediated initiation of Schwann cell myelination |
| WP:WP5087 | 0.0029183957539 | 0.75 | TEAD2 WWTR1 YAP1 | Pleural mesothelioma |
| REAC:R-HSA-8941326 | 0.00306932002175 | 0.5 | YAP1 WWTR1 | RUNX2 regulates bone development |
| REAC:R-HSA-9758941 | 0.0068064250699 | 0.5 | TEAD2 YAP1 | Gastrulation |
| GO:0140552 | 0.00842684400117 | 0.5 | TEAD2 YAP1 | TEAD-YAP complex |
| WP:WP2857 | 0.0202008249203 | 0.5 | TEAD2 YAP1 | Mesodermal commitment pathway |
| WP:WP5381 | 0.0245369062383 | 0.5 | YAP1 WWTR1 | Smith Magenis and Potocki Lupski syndrome copy number variation |
| CORUM:7062 | 0.0249718442456 | 0.25 | WWTR1 | NFAT5-WWTR1 complex |
| CORUM:6652 | 0.0249718442456 | 0.25 | WWTR1 | WWTR1 homodimer |
| CORUM:6676 | 0.049938562206 | 0.25 | WWTR1 | WWTR1-YWHAQ complex |
| CORUM:6661 | 0.049938562206 | 0.25 | WWTR1 | NEK8-WWTR1 complex |
| CORUM:6655 | 0.049938562206 | 0.25 | YAP1 | CTNNB1-TBX5-YAP1 complex |
| CORUM:6647 | 0.049938562206 | 0.25 | WWTR1 | MED15-WWTR1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| WWTR1 | TEAD2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TEAD2 | YAP1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| AMOTL2 | YAP1 | 0.997 | 0.068 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| WWTR1 | AMOTL2 | 0.975 | 0.104 | hein_WMM bioplex3_WMM WMM_only |
| WWTR1 | YAP1 | 0.974 | 0.114 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes