hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01628.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MKNK2 | MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2) | 5 | UniProt NCBI |
| RHBDF1 | Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) | 5 | UniProt NCBI |
| MAPK14 | Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a) | 5 | UniProt NCBI |
| DUSP16 | Dual specificity protein phosphatase 16 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7) | 5 | UniProt NCBI |
| MKNK1 | MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP382 | 1.07905696272e-05 | 0.8 | MAPK14 MKNK1 MKNK2 DUSP16 | MAPK signaling pathway |
| WP:WP2637 | 1.48411025729e-05 | 0.6 | MAPK14 MKNK2 MKNK1 | Interleukin 1 IL 1 structural pathway |
| KEGG:04010 | 1.78654941634e-05 | 0.8 | MAPK14 MKNK1 MKNK2 DUSP16 | MAPK signaling pathway |
| WP:WP3879 | 0.00123199381981 | 0.4 | MKNK1 MKNK2 | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression |
| WP:WP400 | 0.00254884296025 | 0.4 | MAPK14 MKNK1 | p38 MAPK signaling pathway |
| WP:WP5087 | 0.0098916730515 | 0.6 | MAPK14 MKNK2 MKNK1 | Pleural mesothelioma |
| KEGG:04066 | 0.0217595858915 | 0.4 | MKNK1 MKNK2 | HIF-1 signaling pathway |
| KEGG:04148 | 0.0340898047114 | 0.4 | MAPK14 DUSP16 | Efferocytosis |
| KEGG:04910 | 0.0351932106204 | 0.4 | MKNK1 MKNK2 | Insulin signaling pathway |
| GO:0048273 | 0.0468008499735 | 0.4 | MAPK14 DUSP16 | mitogen-activated protein kinase p38 binding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MAPK14 | MKNK1 | 0.999 | 0.154 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MAPK14 | DUSP16 | 0.986 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MKNK2 | MAPK14 | 0.975 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RHBDF1 | MAPK14 | 0.968 | 0.04 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MKNK2 | RHBDF1 | 0.568 | bioplex_WMM bioplex3_WMM WMM_only | |
| MKNK2 | MKNK1 | 0.551 | bioplex_WMM bioplex3_WMM WMM_only | |
| RHBDF1 | DUSP16 | 0.527 | bioplex_WMM bioplex3_WMM WMM_only | |
| MKNK2 | DUSP16 | 0.498 | bioplex_WMM bioplex3_WMM WMM_only | |
| RHBDF1 | MKNK1 | 0.364 | 0.108 | bioplex_WMM bioplex3_WMM WMM_only |
| DUSP16 | MKNK1 | 0.214 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes