hu.MAP 3.0: Complex View

Genename	Protein Name	Uniprot Annotation Score	Links
APP	Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]	5	UniProt NCBI
CES2	Cocaine esterase (EC 3.1.1.84) (Carboxylesterase 2) (CE-2) (hCE-2) (EC 3.1.1.1) (Methylumbelliferyl-acetate deacetylase 2) (EC 3.1.1.56)	5	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP2645	0.0186595012434	0.5	CES2	Heroin metabolism
WP:WP2826	0.0248784837172	0.5	CES2	Cocaine metabolism
CORUM:2711	0.0249718442457	0.5	APP	Amyloid beta protein homo-oligomer complex
CORUM:6056	0.0249718442457	0.5	APP	APP-TNFRSF21 complex
CORUM:7529	0.0249718442457	0.5	APP	APP-Abeta42-VDAC1 complex
WP:WP136	0.0435328773163	0.5	CES2	Phase I biotransformations non P450
HPA:0151292	0.0440235054965	1.0	CES2 APP	duodenum; endocrine cells[>=Medium]
CORUM:3092	0.0499419797295	0.5	APP	APP-TOM40 complex
CORUM:3093	0.0499419797295	0.5	APP	APP-TIM23 complex
CORUM:7574	0.0499419797295	0.5	APP	APP-PSEN1 complex
CORUM:7575	0.0499419797295	0.5	APP	APP-PSEN2 complex
CORUM:7579	0.0499419797295	0.5	APP	APP(AICD)-MED12 complex
CORUM:7587	0.0499419797295	0.5	APP	APP(AICD)-FOXO3 complex
CORUM:7588	0.0499419797295	0.5	APP	APP(AICD)-FOXO1 complex
CORUM:7589	0.0499419797295	0.5	APP	APP(AICD)-FOXO4 complex
HP:0004968	0.0499436884913	0.5	APP	Recurrent cerebral hemorrhage

Protein 1	Protein 2	Score	ProteomeHD	Evidence
APP	CES2	0.996	0.082	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116

Genename	Complexes
APP	huMAP3_01640.1 huMAP3_10974.1
CES2	huMAP3_01640.1 huMAP3_02642.1 huMAP3_03448.1 huMAP3_07879.1 huMAP3_08861.1 huMAP3_09695.1 huMAP3_10974.1 huMAP3_14537.1